Transcriptome profiling of maize transcription factor mutants to probe gene regulatory network predictions DOI Creative Commons
Erika L. Ellison, Peng Zhou, Yi‐Hsuan Chu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Abstract Transcription factors (TFs) play important roles in regulation of gene expression and phenotype. A variety approaches have been utilized to develop gene-regulatory networks (GRNs) predict the regulatory targets for each TF, such as yeast-one-hybrid (Y1H) screens co-expression network (GCN) analysis. Here we identified potential TF used a reverse genetics approach test predictions several GRNs maize. Loss-of-function mutant alleles were isolated 22 maize TFs. These mutants did not exhibit obvious morphological phenotypes. However, transcriptomic profiling differentially expressed genes genotypes, targeted metabolic indicated variable phenolic accumulation some mutants. An analysis levels predicted target based on Y1H small subset that altered levels. The from GCN-based methods found significant enrichments prediction sets TFs, but most expression. This could result false-positive GCN predictions, with secondary role resulting minor effects regulation, or redundant by other Collectively, these findings suggest loss-of-function single uncharacterized TFs might limited phenotypic impacts can reveal subsets GRN

Language: Английский

Genome-wide identification and expression analysis of C3H gene family in melon DOI Creative Commons
Ling Zheng, Haiyan Dai, Mu Yang

et al.

Frontiers in Plant Science, Journal Year: 2025, Volume and Issue: 16

Published: March 13, 2025

Zinc finger protein (ZFP) represent a significant class of transcription factors in plants, involved various functions, including tissue development, signal transduction, and responses to both biotic abiotic stresses. ZFPs are categorized into 10 distinct subfamilies, among which the C3H gene family is recognized as functionally group factors.To date, no studies have been reported regarding melon ( Cucumis melo ). In this study, 38 CmC3H genes were identified genome, these unevenly distributed across 12 chromosomes. Phylogenetic analysis classified members four groups, with differences observed sequence, motifs, structure within same group. The contains one pair segmentally duplicated shares 20, 7, 39, pairs homologous Arabidopsis thaliana , rice Oryza sativa ), cucumber sativus watermelon Citrullus lanatus respectively. Promoter region revealed high abundance cis -elements associated growth hormone regulation, stress responses. Expression profiling that exhibit tissue-specific expression patterns. Quantitative PCR indicated six CmC3H4 CmC3H7 CmC3H13 CmC3H24 CmC3H33 CmC3H38 ) may play roles melon’s drought resistance. Heavy metal lead appears suppress genes. be regulating resistance Fusarium wilt infection. CmC3H11 CmC3H21 can considered key candidate for improving ability resist stresses.This study provides preliminary insights profiles under stress, heavy infection, offering theoretical foundation molecular mechanisms underlying improvement

Language: Английский

Citations

0

Harnessing the Power of Transcription Factors for Crop Improvement: Insights from Stress Tolerance, Development, and Metabolic Regulation DOI Creative Commons
Nan Jiang, Ernesto Picardi

Current Plant Biology, Journal Year: 2025, Volume and Issue: unknown, P. 100488 - 100488

Published: May 1, 2025

Language: Английский

Citations

0

GRASSIUS 2.0: A gene regulatory information knowledgebase for maize and other grasses DOI Creative Commons
John C. Gray, Yi‐Hsuan Chu, Ankita Abnave

et al.

Current Plant Biology, Journal Year: 2024, Volume and Issue: unknown, P. 100396 - 100396

Published: Oct. 1, 2024

Language: Английский

Citations

1

Transcriptome profiling of maize transcription factor mutants to probe gene regulatory network predictions DOI Creative Commons
Erika L. Ellison, Peng Zhou, Yi‐Hsuan Chu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Abstract Transcription factors (TFs) play important roles in regulation of gene expression and phenotype. A variety approaches have been utilized to develop gene-regulatory networks (GRNs) predict the regulatory targets for each TF, such as yeast-one-hybrid (Y1H) screens co-expression network (GCN) analysis. Here we identified potential TF used a reverse genetics approach test predictions several GRNs maize. Loss-of-function mutant alleles were isolated 22 maize TFs. These mutants did not exhibit obvious morphological phenotypes. However, transcriptomic profiling differentially expressed genes genotypes, targeted metabolic indicated variable phenolic accumulation some mutants. An analysis levels predicted target based on Y1H small subset that altered levels. The from GCN-based methods found significant enrichments prediction sets TFs, but most expression. This could result false-positive GCN predictions, with secondary role resulting minor effects regulation, or redundant by other Collectively, these findings suggest loss-of-function single uncharacterized TFs might limited phenotypic impacts can reveal subsets GRN

Language: Английский

Citations

0