Mortality and burden related with aortic aneurysms and dissections. The importance of information and education

Current Problems in Cardiology, Journal Year: 2024, Volume and Issue: 49(3), P. 102384 - 102384

Published: Jan. 4, 2024

In this study we correlated changes of risk factors for cardiovascular diseases with trends age standardized mortality rates and burden aortic aneurysms dissections. We analyzed data from the Global Burden Diseases EUROSTAT. There was a significant increase expenditure health 1980 2019. period 1980-2000, despite higher spending, increased in almost all European countries. During 2000-2019, Western Countries Poland, Estonia, Latvia, Slovenia there correlation between decrease ASMR. The most important 1980-2000 2000-2019 proportion devoted to preventive care use aspirin statins. Information about have leads decreased aneurysm related burden.

Language: Английский

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GMRSP encoded by lncRNA H19 regulates metabolic reprogramming and alleviates aortic dissection

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 18, 2025

Language: Английский

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Circadian Rhythms and Cardiovascular Integrity: Unveiling the Influence of Sleep Patterns on Aortic Aneurysm and Dissection in the UK Biobank Cohort

Published: Jan. 1, 2025

Language: Английский

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The associations between circulating amino acids and arterial aneurysms and dissection: A bidirectional Mendelian randomization study

International Journal of Cardiology Cardiovascular Risk and Prevention, Journal Year: 2025, Volume and Issue: 25, P. 200388 - 200388

Published: March 7, 2025

Circulating amino acid levels can be altered in arterial aneurysms and dissection, but the relationships between them is unclear. The present study investigated causal relationship circulating dissection via bidirectional two-sample Mendelian randomization (MR). A MR analysis was used. Forward performed with as exposure outcomes. Reverse exposures data were analyzed using five analytical methods: inverse-variance weighted (IVW), MR‒Egger, median, simple, methods. IVW used main method, other methods for supplementary analyses. Heterogeneity assessed Cochran's Q test, horizontal pleiotropy intercepts from MR‒Egger regression. genome-wide association (GWAS) acids obtained IEU open GWAS database Catalog database. Finngen consortium version R10. tyrosine level negatively correlated (P = 0.00211, OR: 0.57, 95 % CI: 0.40, 0.82). Aortic decreased glycine 0.00168, 0.98, 0.99). Through analysis, we found that aortic reduced glycine. Our findings support a possible interaction dissection.

Language: Английский

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Independent and Interactive Roles of Immunity and Metabolism in Aortic Dissection

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(21), P. 15908 - 15908

Published: Nov. 2, 2023

Aortic dissection (AD) is a cardiovascular disease that seriously endangers the lives of patients. The mortality rate this high, and incidence increasing annually, but pathogenesis AD complicated. In recent years, an number studies have shown immune cell infiltration in media adventitia aorta novel hallmark AD. These cells contribute to changes microenvironment, which can affect their own metabolism parenchymal aortic wall, are essential factors induce degeneration remodeling vascular wall play important roles formation development Accordingly, review focuses on independent interactive immunity provide further insights into pathogenesis, ideas for diagnosis new strategies treatment or early prevention

Language: Английский

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Enhancer of zeste homolog 2 facilitates phenotypic transition of vascular smooth muscle cells leading to aortic aneurysm/dissection

Experimental and Therapeutic Medicine, Journal Year: 2024, Volume and Issue: 27(4)

Published: Feb. 19, 2024

Thoracic aortic aneurysms (TAAs) are a major cause of death owing to weaker blood vessel walls and higher rupture rates in affected individuals. Vascular smooth muscle cells (VSMCs) the predominant cell type within wall their dysregulation may contribute TAA progression. Enhancer zeste homolog 2 (EZH2), histone methyltransferase, is involved several pathological processes; however, biological functions mechanisms underlying VSMC phenotype transition vascular intimal hyperplasia remain unclear. The present study aimed determine involvement EZH2 mediating function development TAAs. expression was revealed be elevated patients with thoracic dissection mouse model through western blotting reverse transcription‑quantitative PCR experiments. Subsequently, established using β‑aminopropionitrile. In vitro, EdU labeling, Transwell assay, wound healing assay hematoxylin‑eosin staining that knocking down Ezh2 gene could reduce proliferation, invasion, migration, calcification primary cells. Flow cytometry analysis found deficiency increased apoptosis. Depletion VSMCs promoted transformation from synthetic contractile phenotype. Using RNA‑sequencing analysis, it demonstrated regulated group genes, including integrin β3 (Itgb3), which critically extracellular matrix signaling pathway. qChIP occupies Itgb3 promoter, thereby suppressing Itgb3. promotes invasion VSMCs, this promoting effect partially reversed by co‑knocking In conclusion, identified previously unrecognized EZH2‑ITGB3 regulatory axis thus provides novel mechanistic insights into pathophysiological EZH2. serve as potential target for management

Language: Английский

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Diabetes and aortic dissection: unraveling the role of 3-hydroxybutyrate through mendelian randomization

Cardiovascular Diabetology, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 7, 2024

In observational and experimental studies, diabetes has been reported as a protective factor for aortic dissection. 3-Hydroxybutyrate, key constituent of ketone bodies, found to favor improvements in cardiovascular disease. However, whether the effect on dissection is mediated by 3-hydroxybutyrate unclear. We aimed investigate causal effects risk mediating role them through two-step Mendelian randomization.

Language: Английский

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Effect of serum uric acid on the risk of aortic aneurysm and dissection: A mendelian randomization analysis

Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 38, P. 101743 - 101743

Published: May 30, 2024

Aortic aneurysm and dissection (AAD) are severe vascular diseases with high mortality rates. However, the causal relationship between serum uric acid levels occurrence of AAD remains a subject controversy. To address this issue, we conducted two-sample Mendelian randomization (MR) analysis to investigate whether there is association these factors. We obtained single-nucleotide polymorphisms (SNPs) data related from FinnGen study on UK Biobank. Various MR methods, including inverse variance weighted (IVW) analysis, MR-Egger regression median contamination mixture method, were employed assess risk AAD. Sensitivity was evaluate stability reliability results. The findings revealed positive aortic (AA) (odds ratio [OR] = 1.200, 95 % confidence interval [CI]: 1.020–1.400, P 0.0239). no significant correlation observed (AD) (OR 0.893, CI 0.602–1.326, 0.576). Our study, which identified AA. did not observe AD.

Language: Английский

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HDL-C mediates the causal relationship between serum urate and aortic aneurysm: a Mendelian randomization study

Cardiology Plus, Journal Year: 2024, Volume and Issue: 9(3), P. 180 - 186

Published: July 1, 2024

Background and purpose: Studies have indicated a close relationship between serum urate an increased risk of aortic aneurysm or dissection. However, the causality them mediators this association not been identified. This study employs bidirectional multivariable Mendelian randomization (MR) to investigate dissection identify relationship. Methods: We first investigated causal using two-sample MR, with inverse-variance-weighted method as principal analysis technique. Subsequently, we applied MR determine probable mediators. Results: Genetically levels were linked (odds ratio [OR]: 1.160, 95% confidence interval [95% CI]: 1.011–1.332, P = 0.034), high-density lipoprotein cholesterol (HDL-C) mediating relationship, accounting for 10.2% effect. No was found Conclusions: Serum is factor aneurysm, mediated through HDL-C. Monitoring HDL-C in patients hyperuricemia essential prevent slow progression aneurysm.

Language: Английский

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Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model

Animal Cells and Systems, Journal Year: 2024, Volume and Issue: 28(1), P. 84 - 92

Published: March 1, 2024

Aortic aneurysm/dissection (AAD) poses a life-threatening cardiovascular emergency with complex mechanisms and notably high mortality rate. Zebrafish (Danio rerio) serve as valuable models for AAD due to the conservation of their three-layered arterial structure genome that humans. However, existing studies have predominantly focused on larval zebrafish, leaving gap in our understanding adult zebrafish. In this study, we utilized β-Aminopropionic Nitrile (BAPN) impregnation induce both Following induction, zebrafish exhibited 28% widening dorsal aortic diameter (p < 0.0004, n = 10) arch malformations, malformation rate 75% (6/8). Conversely, showed 41.67% (5/12) 22 days post-induction. At time point, area had expanded by 2.46 times 0.009), vessel wall demonstrated significant thickening (8.22 ± 2.23 μM vs. 26.38 10.74 μM, p 0.05). Pathological analysis revealed disruptions smooth muscle layer, contributing 58.33% aneurysm Moreover, expression levels acta2, tagln, cnn1a, cnn1b were decreased, indicating weakened contractile phenotype. Transcriptome sequencing overlap between molecular features tissues post-BAPN treatment those patients. Our findings present straightforward practical method generating using BAPN.

Language: Английский

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