A cohort study of serum 25-hydroxyvitamin D levels and the risk of hyperlipidaemia in adults

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 24, 2025

Objective This study aims to investigate the potential association between serum 25(OH)D levels and risk of hyperlipidemia in adults through a prospective cohort conducted Zhejiang Province. Methods Baseline surveys follow-up studies were collect analyze data over three-year period. Vitamin D deficiency was defined as < 20 ng/mL, insufficiency 20–29 sufficiency ≥ 30 ng/mL. Hyperlipidemia or dyslipidemia presence hypercholesterolemia, hypertriglyceridemia, both. The relationship demographic characteristics incidence among participants explored. Results A total 1,210 included this study, with 43.80% being male. mean age 51.84 ± 14.37 years, average level 25.89 (21.50, 29.82) significant difference proportion vitamin observed males females (22.06% vs. 10.94%, p 0.001). prevalent middle-aged elderly population (78.24%). Significant differences found two groups multiple sociodemographic variables, behavioral factors, metabolic factors ( 0.05). D-deficient individuals 1.612 times higher than that D-sufficient (95% confidence interval [CI]: 1.228–2.116; After fully adjusting for confounding multivariate-adjusted hazard ratio (HR) 1.572 CI: 1.187–2.08; = 0.002), indicating across different levels. Conclusion reveals hyperlipidemia. Additionally, lifestyle associated are also correlated These findings provide further evidence improving blood lipid profiles adjustments intake related modifications.

Language: Английский

Traditional Chinese medicine and plant-derived natural products in regulating triglyceride metabolism: Mechanisms and therapeutic potential

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107387 - 107387

Published: Aug. 30, 2024

The incidence of cardiometabolic disease is increasing globally, with a trend toward younger age onset. Among these, atherosclerotic cardiovascular leading cause mortality worldwide. Despite the efficacy traditional lipid-lowering drugs, such as statins, in reducing low-density lipoprotein cholesterol levels, significant residual risk events remains, which closely related to unmet triglyceride (TG) targets. clinical application current TG-lowering Western medicines has certain limitations, necessitating alternative or complementary therapeutic strategies. Traditional Chinese medicine (TCM) and plant-derived natural products, known for their safety owing origins diverse biological activities, offer promising avenues TG regulation potentially fewer side effects. This review systematically summarises mechanisms metabolism subsequently reviews regulatory effects TCM products on metabolism, including inhibition synthesis (via endogenous exogenous pathways), promotion catabolism, fatty acid absorption transport, enhancement lipophagy, modulation gut microbiota, other mechanisms. In conclusion, through comprehensive analysis recent studies, this consolidates multifaceted roles elucidates potential safer, multi-target agents managing hypertriglyceridemia mitigating risk, thereby providing basis new drug development.

Language: Английский