Exploring the relationship between red blood cell levels and emotional regulation through the miR191-Riok3-Mxi1 pathway DOI Creative Commons
Da Zhang, Xiaoqing Zhang, Yang Li

et al.

Journal of Traditional Chinese Medical Sciences, Journal Year: 2023, Volume and Issue: 11(1), P. 101 - 110

Published: Nov. 10, 2023

To assess emotional fluctuations, physical and mental health status, indicators closely related to red blood cells, such as RIO kinase 3 (Riok3), MAX interactor 1 (Mxi1), microRNA 191 (miR191), in participants with different levels of cells. Participants who underwent examinations at Dongfang Hospital between April October 2019 were divided into healthy, deficiency, anemia groups (30 individuals the healthy deficiency group respectively, 13 group) according our inclusion exclusion criteria. The conditions evaluated through questionnaires, fluctuations assessed an emotion-inducing experiment, which watched video segments designed induce specific emotions. Relative expression miR191, Riok3, Mxi1 from venous samples also determined. main psychological factors identified obsessive-compulsive symptoms, depression, anxiety, other negative gene indicated that miR191 was upregulated Riok3 downregulated both groups. Regarding score disgust on stage, effect significant (F = 335.58, P .00), showed watching three videos caused have a dominant emotion, there is difference 5.35, .01), higher scores symptoms anemia, weakness limbs significantly negatively correlated (r =﹣0.38 ﹣0.31 respectively), but positively 0.29). We determined close relationship exists cell status. Our findings suggest are more likely experience problems emotions, particularly disgust. demonstrate regulation mir191-Riok3-Mxi1 pathway activity, identifying these components potential targets for genetic therapies combination therapy.

Language: Английский

Analysis of Maternal-Fetal Heart Rate Coupling in Preeclamptic Women in Labor Using Time-Frequency Coherence DOI
Adelaida María Castro‐Sánchez, José Javier Reyes–Lagos, Eric Alonso Abarca-Castro

et al.

IFMBE proceedings, Journal Year: 2025, Volume and Issue: unknown, P. 427 - 435

Published: Jan. 1, 2025

Language: Английский

Citations

0
Identifying behavior regulatory leverage over mental disorders transcriptomic network hubs toward lifestyle-dependent psychiatric drugs repurposing DOI Creative Commons

Mennatullah Abdelzaher Turky,

Ibrahim Youssef, Azza El Amir

et al.

Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 19, 2025

Abstract Background There is a vast prevalence of mental disorders, but patient responses to psychiatric medication fluctuate. As food choices and daily habits play fundamental role in this fluctuation, integrating machine learning with network medicine can provide valuable insights into disease systems the regulatory leverage lifestyle health. Methods This study analyzed coexpression modules MDD PTSD blood transcriptomic profile using modularity optimization method, first runner-up Disease Module Identification DREAM challenge . The top genes both were detected random forest model. Afterward, signature two predominant habitual phenotypes, diet-induced obesity smoking, identified. These transcription/translation regulating factors ( TRFs ) signals transduced toward disorders’ genes. A bipartite drugs that target TRFS together or hubs was constructed. Results research revealed one hub, CENPJ, which known influence intellectual ability. observation paves way for additional investigations potential CENPJ as novel therapeutic agents development. Additionally, most predicted associated multiple carcinomas, notable SHCBP1. SHCBP1 risk factor glioma, suggesting importance continuous monitoring patients mitigate cancer comorbidities. signaling illustrated three biomarkers co-regulated by phenotype TRFs. 6-Prenylnaringenin Aflibercept identified candidates targeting hubs: ATP6V0A1 PIGF. However, have no over Conclusion Combining biology succeeded revealing notoriously spreading PTSD. approach offers non-invasive diagnostic pipeline identifies drug targets could be repurposed under further investigation. findings contribute our understanding complex interplay between habits, interventions, thereby facilitating more targeted personalized treatment strategies.

Language: Английский

Citations

0
The effects of the pregnant woman’s mental visualization of her baby during the non-stress test on maternal anxiety and fetal parameters: A randomized controlled clinical trial DOI
Fatma Keskin Töre, Cansu Ağralı, Gülçin Nacar

et al.

Advances in Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100508 - 100508

Published: May 1, 2025

Language: Английский

Citations

0
Antenatal Noninvasive Fetal Electrocardiography: A Literature Review DOI Creative Commons

Claire Pegorie,

Becky Liu, B. Thilaganathan

et al.

Maternal-Fetal Medicine, Journal Year: 2024, Volume and Issue: 6(3), P. 178 - 189

Published: July 1, 2024

Fetal heart rate (FHR) monitoring is one of the central parts obstetric care. Ultrasound-based technologies such as cardiotocography (CTG) remain most common method for FHR monitoring. The CTG's limitations, including subjective interpretation, high interobserver variability, and need skilled professionals, led to development computerized CTG (cCTG). While cCTG demonstrated advantages, its superiority over visual interpretation remains inconclusive. This has prompted exploration alternatives like noninvasive fetal electrocardiography (NIFECG). review explores landscape antenatal remote in a patient-centered care model. Additionally, needs evolve from traditional approach incorporate artificial intelligence machine learning. underscores importance aligning with modern healthcare, leveraging algorithms accurate assessments, enhancing patient engagement. physiology variability (FHRV) explained emphasizing significance assessing well-being. Other measures FHRV their relevance are described. It delves into promising realm NIFECG, detailing history recent technological advancements. potential advantages NIFECG objective assessment, beat-to-beat comfort, prolonged use, less signal loss increased maternal body mass index. Despite promise, challenges must be addressed. clinical application correlation measures, ongoing advancements discussed. In conclusion, this evolution monitoring, providing reliable, home-based solutions. Future research directions outlined, urging longitudinal studies evidence generation establish NIFECG's role well-being assessments during pregnancy.

Language: Английский

Citations

2
Visceral afferent training in action: The origins of agency in early cognitive development DOI Open Access
Andrew W. Corcoran, Daniel Feuerriegel, Jonathan Robinson

et al.

Published: July 24, 2023

The foetal period constitutes a critical stage in the construction and organisation of mammalian nervous system. In recent work, we have proposed that brain development is structured by bottom-up (interoceptive) inputs from spontaneous physiological rhythms such as heartbeat (Corcoran et al., 2024). Here, expand this visceral afferent training hypothesis to incorporate top-down (allostatic) control over bodily states. We conceptualise emergence cardiac regulation an early instance sensorimotor contingency learning scaffolds agentic control. further propose brain’s capacity actively modify regulate feedback it receives through interoceptive (and other) channels – parse these signals into their self-generated (reafferent) externally-generated (exafferent) components crucial for grounding distinction between self other. Finally, explore how individual differences ways regimes are implemented (or disrupted) might impact developmental trajectories gestation infancy, potentiating neurobehavioural diversity disease risk later life.

Language: Английский

Citations

4
Visceral afferent training in action: The origins of agency in early cognitive development DOI Creative Commons
Andrew W. Corcoran, Daniel Feuerriegel, Jonathan Robinson

et al.

Developmental Review, Journal Year: 2024, Volume and Issue: 75, P. 101184 - 101184

Published: Dec. 28, 2024

Language: Английский

Citations

1
Physiologic Network-Based Brain-Heart Interaction Quantification During Visual Emotional Elicitation DOI Creative Commons
Zhipeng Cai, Hongxiang Gao, Min Wu

et al.

IEEE Transactions on Neural Systems and Rehabilitation Engineering, Journal Year: 2024, Volume and Issue: 32, P. 2482 - 2491

Published: Jan. 1, 2024

In recent years, there has been a surge in interest regarding the intricate physiological interplay between brain and heart, particularly during emotional processing. This led to development of various signal processing techniques aimed at investigating Brain-Heart Interactions (BHI), reflecting growing appreciation for their bidirectional communication influence on each other. Our study contributes this burgeoning field by adopting network physiology approach, employing time-delay stability as quantifiable metric discern measure coupling strength specifically visual elicitation. We extract transform features from EEG ECG signals into 1 Hz format, facilitating calculation BHI through analysis maximal cross-correlation. Notably, our investigation sheds light critical role played low-frequency components EEG, $\delta $ , notation="LaTeX">$\theta notation="LaTeX">$\alpha bands, essential mediators information transmission complex emotion-related stimuli brain. Furthermore, highlights pivotal involvement frontal pole regions, emphasizing significance - mediating responses. Additionally, we observe significant arousal-dependent changes frequency band across different states, evident prefrontal cortex. By offering novel insights synchronized dynamics cortical heartbeat activities elicitation, research enriches expanding knowledge base neurophysiology emotion research.

Language: Английский

Citations

0
Effect of Maternal Respiration on Fetal Heart Rate Variability DOI
Namareq Widatalla, Ahsan H. Khandoker

Published: July 15, 2024

Fetal development assessment is largely carried out by measurements of non-invasive fetal heart rate (fHR) throughout gestation. Different literature demonstrated that HR and variability (HRV) are affected different maternal factors such as weight, exercise, respiration. Up until now, more knowledge needed to understand how the mother affects because this may enhance both health during pregnancy. Previously, respiration was found affect coupling interaction between fetus. However, it still unknown HRV. In study, we investigated associations respiratory power spectrum density (PSD) rates with RR interval (fRRI) (HRV). Maternal recorded using a thoracic belt RRI HRV were calculated from PulsedWave Doppler (PWD) images. The total number data used in study 25 (gestational age (GA): (24 ± 2.0) weeks, age: (33 5.2) years old). publicly available online at physionet.

Language: Английский

Citations

0
The level of stress in pregnant women during hospitalization in the Pregnancy Pathology department DOI Open Access
Wiktoria Postępska, Katarzyna Kanadys, Jan Jakub Kęsik

et al.

Kwartalnik Naukowy Fides et Ratio, Journal Year: 2023, Volume and Issue: 55(3), P. 58 - 66

Published: Sept. 22, 2023

Introduction and aims. Pregnancy is a physiological state for woman. However, if pathology develops, the course of pregnancy affected by both mental biological stress. Stress experienced during may irreversibly alter cerebral structures in foetus. Moreover, chronic stress likely to cause miscarriage, preterm delivery, IUGR, low birth weight, etc. The aim study was analyse level hospitalized pregnant women with account forsociodemographic factors. Material methods. carried out group 140 Department Pathology, Independent State Clinical Hospital No.1 Lublin. Inclusion criteria were: age 18 or older, established pregnancy, hospitalization more than 2 weeks department. participants were diagnostically surveyed Perceptible Scale (PSS-10) questionnaire created study. Results. Almost every second (76; 54.3%) woman demonstrated stress, 13.6% (n=19) respondents showed average level, high detected 32.1% (n= 45) respondents. A statistically significant correlation found between perceived education (p=0.031), financial situation (p=0.017). Conclusions. During hospitalization, nearly third very fact that health child and/or mother be at risk already source Higher intensity - concerned mothers professional situation. Data from reports literature indicate can also negatively affect psycho-physical diady- child. Further research this area needed, along possibility taking measures promote psychophysical comfort mothers.

Language: Английский

Citations

0
Exploring the relationship between red blood cell levels and emotional regulation through the miR191-Riok3-Mxi1 pathway DOI Creative Commons
Da Zhang, Xiaoqing Zhang, Yang Li

et al.

Journal of Traditional Chinese Medical Sciences, Journal Year: 2023, Volume and Issue: 11(1), P. 101 - 110

Published: Nov. 10, 2023

To assess emotional fluctuations, physical and mental health status, indicators closely related to red blood cells, such as RIO kinase 3 (Riok3), MAX interactor 1 (Mxi1), microRNA 191 (miR191), in participants with different levels of cells. Participants who underwent examinations at Dongfang Hospital between April October 2019 were divided into healthy, deficiency, anemia groups (30 individuals the healthy deficiency group respectively, 13 group) according our inclusion exclusion criteria. The conditions evaluated through questionnaires, fluctuations assessed an emotion-inducing experiment, which watched video segments designed induce specific emotions. Relative expression miR191, Riok3, Mxi1 from venous samples also determined. main psychological factors identified obsessive-compulsive symptoms, depression, anxiety, other negative gene indicated that miR191 was upregulated Riok3 downregulated both groups. Regarding score disgust on stage, effect significant (F = 335.58, P .00), showed watching three videos caused have a dominant emotion, there is difference 5.35, .01), higher scores symptoms anemia, weakness limbs significantly negatively correlated (r =﹣0.38 ﹣0.31 respectively), but positively 0.29). We determined close relationship exists cell status. Our findings suggest are more likely experience problems emotions, particularly disgust. demonstrate regulation mir191-Riok3-Mxi1 pathway activity, identifying these components potential targets for genetic therapies combination therapy.

Language: Английский

Citations

0