Cancers,
Journal Year:
2025,
Volume and Issue:
17(5), P. 908 - 908
Published: March 6, 2025
Aim:
An
Early-Stage
Non-Small
Cell
Lung
Cancer
(ES-NSCLC)
patient
candidate
for
stereotactic
body
radiotherapy
(SBRT)
may
start
their
treatment
without
a
histopathological
assessment,
due
to
relevant
comorbidities.
The
aim
of
this
study
is
twofold:
(i)
build
prognostic
models
test
the
association
between
CT-derived
radiomic
features
(RFs)
and
outcomes
interest
(overall
survival
(OS),
progression-free
(PFS)
loco-regional
(LRPFS));
(ii)
quantify
whether
combination
clinical
descriptors
yields
better
prediction
than
alone
in
modeling
ES-NSCLC
patients
treated
with
SBRT.
Methods:
Simulation
CT
scans
curative-intent
SBRT
at
European
Institute
Oncology
(IEO),
Istituto
di
Ricovero
e
Cura
Carattere
Scientifico
(IRCCS),
Milan,
Italy
2013
2023
were
retrospectively
retrieved.
PyRadiomics
v3.0.1
was
used
image
preprocessing
subsequent
RFs
extraction
selection.
A
score
calculated
each
patient,
three
(clinical
model,
clinical-radiomic
model)
endpoint
built.
Relative
performances
compared
using
C-index.
All
analyses
considered
statistically
significant
if
p
<
0.05.
statistical
performed
R
Software
version
4.1.
Results:
total
100
met
inclusion
criteria.
Median
age
diagnosis
76
(IQR:
70–82)
years,
median
Charlson
Comorbidity
Index
(CCI)
7
6–8).
At
last
available
follow-up,
free
disease,
17
alive
deceased.
Considering
relapses,
progression
any
kind
diagnosed
31
cases.
Regarding
model
performances,
allowed
excellent
discrimination
all
endpoints.
Of
note,
use
proved
be
more
informative
characteristics
both
OS
LRPFS,
but
not
PFS,
which
individual
predictive
slightly
favored
model.
Conclusion:
outcome
setting
promising,
results
seem
rather
consistent
across
studies,
despite
some
methodological
differences
that
should
acknowledged.
Further
studies
are
being
planned
our
group
externally
validate
these
findings,
determine
potential
as
non-invasive
reproducible
biomarkers
ES-NSCLC.
Cancer
is
one
of
the
leading
causes
death,
making
timely
diagnosis
and
prognosis
very
important.
Utilization
AI
(artificial
intelligence)
enables
providers
to
organize
process
patient
data
in
a
way
that
can
lead
better
overall
outcomes.
This
review
paper
aims
look
at
varying
uses
for
clinical
utility.
PubMed
EBSCO
databases
were
utilized
finding
publications
from
January
1,
2013,
December
22,
2023.
Articles
collected
using
key
search
terms
such
as
“artificial
intelligence”
“machine
learning.”
Included
collection
studies
application
determining
cancer
multi-omics
data,
radiomics,
pathomics,
laboratory
data.
The
resulting
89
categorized
into
eight
sections
based
on
type
then
further
subdivided
two
subsections
focusing
prognosis,
respectively.
8
integrated
more
than
form
omics,
namely
genomics,
transcriptomics,
epigenomics,
proteomics.
Incorporating
alongside
omics
represents
significant
advancement.
Given
considerable
potential
this
domain,
ongoing
prospective
are
essential
enhance
algorithm
interpretability
ensure
safe
integration.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: March 7, 2023
Objective
To
establish
a
nomogram
based
on
non-enhanced
computed
tomography(CT)
imaging
radiomics
and
clinical
features
for
use
in
predicting
the
malignancy
of
sub-centimeter
solid
nodules
(SCSNs).
Materials
methods
Retrospective
analysis
was
performed
records
198
patients
with
SCSNs
that
were
surgically
resected
examined
pathologically
at
two
medical
institutions
between
January
2020
June
2021.
Patients
from
Center
1
included
training
cohort
(n
=
147),
2
external
validation
52).
Radiomic
extracted
chest
CT
images.
The
least
absolute
shrinkage
selection
operator
(LASSO)
regression
model
used
radiomic
feature
extraction
computation
scores.
Clinical
features,
subjective
findings,
scores
to
build
multiple
predictive
models.
Model
performance
by
evaluating
area
under
receiver
operating
characteristic
curve
(AUC).
best
selected
efficacy
evaluation
cohort,
column
line
plots
created.
Results
Pulmonary
malignant
significantly
associated
vascular
alterations
both
(p
<
0.001)
cohorts.
Eleven
after
dimensionality
reduction
calculate
Based
these
three
prediction
models
constructed:
(Model
1),
score
2),
comprehensive
3),
AUCs
0.672,
0.888,
0.930,
respectively.
optimal
an
AUC
0.905
applied
decision
indicated
plot
clinically
useful.
Conclusion
Predictive
constructed
CT-based
can
help
clinicians
diagnose
pulmonary
guide
making.
Frontiers in Oncology,
Journal Year:
2023,
Volume and Issue:
13
Published: Oct. 23, 2023
Objective
The
purpose
of
this
study
was
to
evaluate
the
diagnostic
performance
computed
tomography
(CT)
scan–based
radiomics
in
prediction
lymph
node
metastasis
(LNM)
gastric
cancer
(GC)
patients.
Methods
PubMed,
Embase,
Web
Science,
and
Cochrane
Library
databases
were
searched
for
original
studies
published
until
10
November
2022,
satisfying
inclusion
criteria
included.
Characteristics
included
approach
data
constructing
2
×
tables
extracted.
quality
score
(RQS)
Quality
Assessment
Diagnostic
Accuracy
Studies
(QUADAS-2)
utilized
assessment
studies.
Overall
sensitivity,
specificity,
odds
ratio
(DOR),
area
under
curve
(AUC)
calculated
assess
accuracy.
subgroup
analysis
Spearman’s
correlation
coefficient
done
exploration
heterogeneity
sources.
Results
Fifteen
with
7,010
GC
patients
We
conducted
analyses
on
both
signature
combined
(based
clinical
features)
models.
pooled
DOR,
AUC
models
compared
0.75
(95%
CI,
0.67–0.82)
versus
0.81
0.75–0.86),
0.80
0.73–0.86)
0.85
0.79–0.89),
13
7–23)
23
13–42),
0.81–0.86)
0.90
0.87–0.92),
respectively.
meta-analysis
indicated
a
significant
among
revealed
that
arterial
phase
CT
scan,
tumoral
nodal
regions
interest
(ROIs),
automatic
segmentation,
two-dimensional
(2D)
ROI
could
improve
accuracy
venous
tumoral-only
ROI,
manual
3D
Overall,
quite
acceptable
based
QUADAS-2
RQS
tools.
Conclusion
has
promising
potential
LNM
preoperatively
as
non-invasive
tool.
Methodological
is
main
limitation
Systematic
review
registration
https://www.crd.york.ac.uk/Prospero/display_record.php?RecordID=287676
,
identifier
CRD42022287676.
Irish Journal of Medical Science (1971 -),
Journal Year:
2024,
Volume and Issue:
193(5), P. 2525 - 2530
Published: June 1, 2024
Abstract
The
primary
aim
of
this
study
was
to
systematically
review
current
literature
evaluating
the
use
radiomics
in
establishing
role
magnetic
resonance
imaging
(MRI)
findings
native
knees
predicting
features
osteoarthritis
(OA).
A
systematic
performed
with
respect
PRISMA
guidelines
search
studies
reporting
radiomic
analysis
analyse
patients
knee
OA.
Sensitivity
and
specificity
analyses
were
included
for
meta-analysis.
Following
our
initial
1271
studies,
only
5
met
inclusion
criteria.
This
1730
(71.5%
females)
a
mean
age
55.4
±
15.6
years
(range
24–66).
RQS
16.6
(11–21).
Meta-analysis
demonstrated
pooled
sensitivity
MRI
OA
0.74
(95%
CI
0.71,
0.78)
0.85
0.83,
0.87),
respectively.
results
suggest
that
high
sensitivities
MRI-based
may
represent
potential
biomarker
early
identification
classification
Such
inform
surgeons
facilitate
earlier
non-operative
management
select
pre-symptomatic
patients,
prior
clinical
or
radiological
evidence
degenerative
change.
European Radiology,
Journal Year:
2024,
Volume and Issue:
35(1), P. 202 - 214
Published: July 16, 2024
To
assess
the
methodological
quality
of
radiomics-based
models
in
endometrial
cancer
using
radiomics
score
(RQS)
and
METhodological
radiomICs
(METRICS).
Cancers,
Journal Year:
2024,
Volume and Issue:
16(20), P. 3511 - 3511
Published: Oct. 17, 2024
Lymphoma,
encompassing
a
wide
spectrum
of
immune
system
malignancies,
presents
significant
complexities
in
its
early
detection,
management,
and
prognosis
assessment
since
it
can
mimic
post-infectious/inflammatory
diseases.
The
heterogeneous
nature
lymphoma
makes
challenging
to
definitively
pinpoint
valuable
biomarkers
for
predicting
tumor
biology
selecting
the
most
effective
treatment
strategies.
Although
molecular
imaging
modalities,
such
as
positron
emission
tomography/computed
tomography
(PET/CT),
specifically
Multimedia Tools and Applications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
Radiomics
is
an
innovative
discipline
in
medical
imaging
that
uses
advanced
quantitative
feature
extraction
from
radiological
images
to
provide
a
non-invasive
method
of
interpreting
the
intricate
biological
panorama
diseases.
This
takes
advantage
unique
characteristics
imaging,
where
radiation
or
ultrasound
combines
with
tissues,
reveal
disease
features
and
important
biomarkers
are
invisible
human
eye.
plays
crucial
role
healthcare,
spanning
diagnosis,
prognosis,
recurrences,
treatment
response
assessment,
personalized
medicine.
systematic
approach
includes
image
preprocessing,
segmentation,
extraction,
selection,
classification,
evaluation.
survey
attempts
shed
light
on
roles
selection
classification
play
discovering
forecasting
directions
despite
challenges
posed
by
high
dimensionality
(i.e.,
when
data
contains
huge
number
features).
By
analyzing
47
relevant
research
articles,
this
study
has
provided
several
insights
into
key
techniques
used
across
different
stages
radiology
workflow.
The
findings
indicate
27
articles
utilized
SVM
classifier,
while
23
surveyed
studies
LASSO
approach.
demonstrates
how
these
particular
methodologies
have
been
widely
research.
assessment
did,
however,
also
point
out
areas
require
more
research,
such
as
evaluating
stability
algorithms
adopting
novel
approaches
like
ensemble
hybrid
methods.
Additionally,
we
examine
some
emerging
subfields
within
field
radiomics.