European Journal of Medical and Health Research,
Journal Year:
2024,
Volume and Issue:
2(2), P. 51 - 62
Published: March 1, 2024
Several
plants
have
been
studied
to
find
their
efficacy
and
anti-cancer
activity
in
various
cancers
by
synthesizing
organic
metal
nanoparticles.
However,
usage
of
Semecarpus
anacardium
(SA)
production
green
synthesized
nanoparticles
not
exposed.
In
our
study
we
focused
on
silver
using
the
nut
extracts
from
SA.
Characterization
studies
including
UV-Visible
spectrophotometry
confirmed
nanoparticle
formation
at
412
nm
0.1
mM
427
0.2
AgNPs.
Particle
size
was
recorded
1.4
confirming
effectivity
zeta
potential
respective
charge
-38.6
mV
particle.
Anti-microbial
shown
against
gram
negative
bacteria.
MTT
assay
ovarian
cancer
cell
line,
PA-1.
These
results
depict
excellent
cytotoxic
effect
PA-1
with
an
IC50
value
250
μg/ml.
Flow
cytometry
that
SA
methanolic
inhibited
cycle
G0/G1
phase
induced
apoptosis.
Taken
together,
are
properties
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(1), P. 123 - 123
Published: Jan. 7, 2024
Lung
cancer
demands
innovative
approaches
for
early
detection
and
targeted
treatment.
In
addressing
this
urgent
need,
exosomes
play
a
pivotal
role
in
revolutionizing
both
the
treatment
of
lung
cancer.
Their
remarkable
capacity
to
encapsulate
diverse
range
biomolecules,
traverse
biological
barriers,
be
engineered
with
specific
targeting
molecules
makes
them
highly
promising
diagnostic
markers
precise
drug
delivery
cells.
Furthermore,
an
in-depth
analysis
exosomal
content
biogenesis
offers
crucial
insights
into
molecular
profile
tumors.
This
knowledge
holds
significant
potential
development
therapies
strategies
Despite
notable
progress
field,
challenges
standardization
cargo
loading
persist.
Collaborative
research
efforts
are
imperative
maximize
advance
field
precision
medicine
benefit
patients.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 1180 - 1180
Published: Jan. 18, 2024
Oncolytic
viruses
(OVs)
are
emerging
as
potential
treatment
options
for
cancer.
Natural
and
genetically
engineered
exhibit
various
antitumor
mechanisms.
OVs
act
by
direct
cytolysis,
the
potentiation
of
immune
system
through
antigen
release,
activation
inflammatory
responses
or
indirectly
interference
with
different
types
elements
in
tumor
microenvironment,
modification
energy
metabolism
cells,
antiangiogenic
action.
The
action
is
pleiotropic,
they
show
varied
interactions
host
cells.
An
important
impediment
oncolytic
virotherapy
journey
virus
into
cells
possibility
its
binding
to
biological
nonbiological
vectors.
have
been
demonstrated
eliminate
cancer
that
resistant
standard
treatments
many
clinical
trials
cancers
(melanoma,
lung,
hepatic);
however,
there
several
resistance
per
se.
Therefore,
it
necessary
evaluate
combination
other
modalities,
such
chemotherapy,
immunotherapy,
targeted
therapies,
cellular
increase
response
rate.
This
review
provides
a
comprehensive
update
on
OVs,
their
use
virotherapy,
future
prospects
this
therapy
alongside
therapies
currently
used
treatment.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
13
Published: Jan. 30, 2024
Small
regulatory
RNAs
(sRNAs)
encapsulated
in
outer
membrane
vesicles
(OMVs)
are
critical
post-transcriptional
regulators
of
gene
expression
prokaryotic
and
eukaryotic
organisms.
OMVs
small
spherical
structures
released
by
Gram-negative
bacteria
that
serve
as
important
vehicles
for
intercellular
communication
can
also
play
an
role
bacterial
virulence
host-pathogen
interactions.
These
molecules
interact
with
mRNAs
or
proteins
affect
various
cellular
functions
physiological
processes
the
producing
bacteria.
This
review
aims
to
provide
insight
into
current
understanding
sRNA
localization
highlights
identification,
characterization
functional
implications
these
sRNAs.
By
examining
research
gaps
this
field,
we
aim
inspire
further
exploration
progress
investigating
potential
therapeutic
applications
OMV-encapsulated
sRNAs
diseases.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 2, 2024
Abstract
Non-small
cell
lung
cancer
(NSCLC)
is
a
prevalent
form
of
cancer.
Patients
with
advanced
NSCLC
are
currently
being
treated
various
therapies,
including
traditional
radiotherapy,
chemotherapy,
molecular
targeted
therapies
and
immunotherapy.
However,
considerable
proportion
advance
patients
who
cannot
benefit
from
them.
Consequently,
it
essential
to
identify
novel
research
target
that
offers
an
encouraging
perspective.
The
stimulator
interferon
genes
(STING)
has
emerged
as
such
target.
At
present,
confirmed
activating
STING
in
tumor
cells
can
impede
the
proliferation
metastasis
dormant
cells.
This
review
focuses
on
role
treatment
factors
influencing
its
activation.
Additionally,
explores
correlation
between
activation
diverse
therapy
modalities
for
NSCLC,
Furthermore,
proposes
prospect
innovative
methods
involving
nanoparticles,
aim
using
features
develop
more
strategies
therapy.
Advanced Therapeutics,
Journal Year:
2023,
Volume and Issue:
6(10)
Published: July 3, 2023
Abstract
The
rapid
advancement
of
nanotechnology
in
recent
years
has
opened
new
avenues
investigation
for
biomedical
sciences.
Viral
nanoparticles
(VNPs)
are
formulated
from
plant
viruses,
mammalian
or
bacteriophages.
Based
on
their
structure,
and
synthetic
carriers
have
been
utilized
to
design
bio‐inspired
nanocarriers,
which
serve
as
building
blocks
innovative
therapeutic
applications.
Scientists
can
chemically
genetically
engineer
VNPs
encompass
various
properties,
such
enhancing
functionalization
with
molecules
imaging
reagents,
enabling
targeted
delivery
specific
ligands.
implementation
these
novel
nanocarrier
platforms
revolutionize
treatments
cancer,
infectious
diseases,
chronic
illnesses.
primary
goal
drug
systems
is
localize
cargo
the
target
site,
increasing
benefits
minimizing
off‐target
effects.
This
review
critically
evaluates
major
virus
species
used
applications
therapeutics,
advantages
disadvantages.
Autophagy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
Macropinocytosis
is
a
nonselective
form
of
endocytosis
that
allows
cancer
cells
to
largely
take
up
the
extracellular
fluid
and
its
contents,
including
nutrients,
growth
factors,
etc.
We
first
elaborate
meticulously
on
process
macropinocytosis.
Only
by
thoroughly
understanding
this
entire
can
we
devise
targeted
strategies
against
it.
then
focus
central
role
MTOR
(mechanistic
target
rapamycin
kinase)
complex
1
(MTORC1)
in
regulating
macropinocytosis,
highlighting
significance
as
key
signaling
hub
where
various
pathways
converge
control
nutrient
uptake
metabolic
processes.
The
article
covers
comprehensive
analysis
literature
molecular
mechanisms
governing
initiation,
maturation,
recycling
macropinosomes,
with
an
emphasis
how
these
processes
are
hijacked
sustain
their
growth.
Key
discussions
include
potential
therapeutic
targeting
such
enhancing
drug
delivery
via
pathway,
inhibiting
macropinocytosis
starve
cells,
blocking
degradation
inducing
methuosis
–
cell
death
triggered
excessive
Targeting
represents
novel
innovative
approach
could
significantly
advance
treatment
cancers
rely
pathway
for
survival.
Through
continuous
research
innovation,
look
forward
developing
more
effective
safer
anti-cancer
therapies
will
bring
new
hope
patients.
Advanced Therapeutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
Abstract
The
rise
of
antibiotic‐resistant
bacteria,
driven
by
antibiotic
misuse,
is
a
major
global
health
threat.
Addressing
this
issue
requires
understanding
resistance
mechanisms
and
developing
innovative
solutions.
Clustered
Regularly
Interspaced
Short
Palindromic
Repeats
(CRISPR)‐associated
systems
(Cas),
genome‐editing
tool
derived
from
prokaryotic
defense
mechanisms,
offers
precise
targeting
genes.
By
reprogramming
CRISPR‐Cas,
bacteria
can
be
killed
or
resensitized
to
antibiotics
through
plasmid
curing.
However,
clinical
applications
face
challenges,
particularly
in
delivering
CRISPR‐Cas
components
effectively.
Nanotechnology
has
emerged
as
promising
approach
for
targeted
delivery
tissues
cells.
This
paper
explores
the
molecular
resistance,
emphasizing
structure
function
their
mechanisms.
It
highlights
use
nanoparticles
(NPs)
nanoscale
carriers
deliver
components,
reviewing
recent
studies
that
combine
NPs
CRISPR
target
Additionally,
discusses
current
challenges
future
prospects
field,
underscoring
potential
nanotechnology
combat
resistance.
