Research progress and treatment status of malignant ascites DOI Creative Commons
Jing He, Huiping Zhang

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 16, 2024

Malignant ascites (MA), a common and serious complication of various cancers in the abdominal cavity, originates from extensive infiltration, metastasis, growth cancer cells or on leading to abnormal accumulation fluid cavity formation MA. MA seriously reduces quality life patients, shortens their survival period, generally has poor prognosis. Modern medicine developed strategies for treatment MA, including targeted supportive treatment, diuretic paracentesis, surgical intervention, intraperitoneal administration therapy. Among them, chemotherapy, as one important methods, includes both systemic chemotherapy especially pressurized aerosol (PIPAC), hyperthermic (HIPEC), foam-based (FBIC), providing new choice In addition, innovative methods such gas-based intra-abdominal hyperthermia (GIH) combined with dehydration therapy have also shown promising application prospects. This article delves into multiple aspects its concept, mechanism occurrence, clinical manifestations, differential diagnostic current status research progress. comprehensive review aims provide valuable references effectively controlling improving patients' life, prolonging cycle patients practice. (MA) is cancer, which peritoneum, peritoneal fluid. It manifestation late stage cancer. Its symptoms are stubborn recurrent, can lead pain, bloating, appetite, fatigue, breathing difficulties, even organ failure. The median time 5 6 months. prognosis poor, it imperative seek more active effective plans. reviews aiming certain value patients.

Language: Английский

Tumor specific protein 70 targeted tumor cell isolation technology can improve the accuracy of cytopathological examination DOI
Lixia Zhang,

Yutong Zhou,

Shuxian Yang

et al.

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Abstract Objectives Although existing cytopathological examination is considered essential for the diagnosis of malignant serous effusions, its accuracy pretty low. Tumor specific protein 70 (SP70), which highly expressed on human tumor cell membrane, was identified in our previous study. This study aimed to explore whether SP70 targeted isolation technology with immunomagnetic beads can improve examination. Methods Cytopathological analysis used this In total, 255 cases were enrolled. Serous effusions analyzed by both and new concurrently. Results The sensitivities 51.26 % 85.43 %, respectively, while specificities 100 both. demonstrated a higher interobserver agreement than (kappa coefficient: 0.720 vs . 0.316, p<0.001). addition, it achieved superior diagnostic efficacy malignancy differentiation compared (AUC: 0.927 0.756, follow-up results showed that 74 final clinical positive only analysis. Among these cases, there 58 negative 16 atypical 74.3 (55/74) had been confirmed have serosa metastasis based radiographic evidence, 73.7 (28/38) harbored hotspot mutations. Conclusions As illustrated work, prominently.

Language: Английский

Citations

2
Injectable celastrol-loading emulsion hydrogel for immunotherapy of low-immunogenic cancer DOI Creative Commons
Yu Liu,

Jia Zhang,

Chun-Yu Lai

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Immunotherapy, exemplified by immune checkpoint blockade (ICB), has been extensively employed in antitumor treatments. Nevertheless, its efficacy addressing low-immunogenic tumors not yielded satisfactory results, primarily due to the depletion and inadequate infiltration of effector T cells within tumor microenvironment (TME). Here, we construct an injectable water-in-oil emulsion hydrogel load clinically used Celastrol (Gel@Cel), which addresses limitations Cel's hydrophobicity. Cel can both inhibit cell proliferation promote apoptosis, while simultaneously inducing immunogenic death, through activation AKT MAPK pathways. In a model refractory hepatocellular carcinoma with malignant ascites, intraperitoneal administration Gel@Cel significantly inhibits progression activates effects lipase-controlled release Cel, as compared free Cel. Intriguingly, induces dendritic cells, resulting cytotoxic TME ascites. Furthermore, increases expression programmed death protein ligand-1 (PD-L1) cells. Moreover, combining PD-1 antibody (αPD-1) further enhances effect amplifies activation. conclusion, exhibits promising therapeutic potential treatment tumors, especially when combined ICB therapy.

Language: Английский

Citations

1
Fructus Jujubae cooperated with water-expelling members in Shizao decoction alleviated intestinal injury and malignant ascites by modulating gut microbiota and metabolic homeostasis DOI

Shikang Zhou,

Jin‐Di Xu,

Xiaoqin Gao

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 133, P. 155895 - 155895

Published: July 20, 2024

Language: Английский

Citations

4
Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application DOI Creative Commons

Shiying Fan,

Lujia Zhou, Wenjie Zhang

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: April 18, 2024

Abstract Metastasis poses a major challenge in colorectal cancer (CRC) treatment and remains primary cause of mortality among patients with CRC. Recent investigations have elucidated the involvement disrupted gut microbiota homeostasis various facets CRC metastasis, exerting pivotal influence shaping metastatic microenvironment, triggering epithelial-mesenchymal transition (EMT), so on. Moreover, therapeutic interventions targeting demonstrate promise enhancing efficacy conventional treatments for (mCRC), presenting novel avenues mCRC clinical management. Grounded “seed soil” hypothesis, this review consolidates insights into mechanisms by which imbalanced promotes highlights recent strides leveraging modulation prevention mCRC. Emphasis is placed on considerable potential manipulating within settings managing

Language: Английский

Citations

3
Simultaneous Determination of 14 Bioactive Components in Fangji Huangqi Tang by UHPLC‐QqQ‐MS Technique DOI
Fangfang Xue, Lintong Xie,

Xia Zhang

et al.

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 2, 2025

Fangji Huangqi Tang (FHT) is a traditional prescription frequently utilized in clinical practice, with wide range of applications and good therapeutic effects. Quality control FHT difficult because Chinese medicine compounds usually contain vast array components characterized by significant structural diversity. A quick accurate method to determine the content active constituents was essential, which purpose quality efficacy assessment could be achieved. utilizing UHPLC-QqQ-MS technology multiple reaction monitoring (MRM) mode established quantify 14 bioactive simultaneously. These analytes included tetrandrine, fangchinoline, calycosin, calycosin-7-glucoside, medicarpin, formononetin, atractylenolide I, II, III, liquiritigenin, isoliquiritigenin, liquiritin, isoliquiritin, glycyrrhizic acid. And our knowledge, II reported for first time this paper. The thoroughly validated stable reliable application regarding specificity, linearity, precision, stability, repeatability, accuracy. allowed simultaneous determination diverse structures trace amounts FHT, ultimately achieving its safe appropriate use.

Language: Английский

Citations

0
Meta-analysis on integrative medicine for the treatment of malignant ascites: a comparative study DOI Creative Commons
Yuan Li,

Yanni Lou,

Bo Deng

et al.

Deleted Journal, Journal Year: 2015, Volume and Issue: 35(1), P. 11 - 14

Published: Feb. 1, 2015

To compare the efficacy of integrated Chinese and Western Medicine with that only for treatment malignant ascites. All randomized controlled trials (January 2004 to March 2013) from China National Knowledge Infrastructure Database, Biomedical Literature Wanfang Database were searched keywords. Meta-analysis was conducted by combining odds ratios individual studies. Review Manager 5.0 used analysis. One thousand one hundred fifty-six patients 19 trails included. Of them, 630 treated (the integrative group), 526 alone control group). The showed total effective rate 78.73% in group, 59.13% group. percentage significantly higher group than [OR = 2.85, 95% CI (2.16, 3.74), P < 0.01]. short-term curative effect better Integrative medicine may be beneficial

Language: Английский

Citations

4
Preliminary Exploration of the Relationship between Tumor Microenvironment in Malignant Ascites and Patient Prognosis DOI Creative Commons

Qingzhe Wang,

Chong Cheng, Rui Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 9, 2024

Abstract Malignant ascites (MA) is a common complication of tumors which related to poor prognosis. With the deepening research on tumor microenvironment (TME), influence TME prognosis gradually understood. As special TME, relationship between MA and patients need be explored. 39 samples in West China Hospital from 2018 2022 were collected for immunohistochemical (IHC) staining CD4, CD8, CD11b, CD11c, CD16, CD19, CD163 FOXP3. Through analyzing proportion positive cells ascites-specific survival (ASS) patients, immune infiltration score (ICIS) cell was established. Based Kruskal-Wallis H test, expression CD8 different types significantly (P = 0.014), biliary tract higher than that gastrointestinal (GI) 0.032). According multivariate cox regression analysis, only whether receive chemotherapy an independent prognostic risk factor. ICIS 1 (CD4, CD163, FOXP3) ICIS2 constructed according can effectively predict ASS (ICIS1: High vs low expression, HR, 0.43, 95%CI (0.22–0.84), P 0.0065; ICIS2: high vs. 0.36, (0.16–0.79), 0.0007). In general, are patients. The distribution model based has good predictive value

Language: Английский

Citations

0
Clinical implications of CT-detected ascites in gastric cancer: association with peritoneal metastasis and systemic inflammatory response DOI Creative Commons

Mengying Xu,

Dan Liu,

Le Wang

et al.

Insights into Imaging, Journal Year: 2024, Volume and Issue: 15(1)

Published: Oct. 7, 2024

This study aimed to evaluate the diagnostic significance of computed tomography (CT) detected ascites in gastric cancer (GC) with peritoneal metastasis (PM) and investigate its association systemic inflammatory response.

Language: Английский

Citations

0
Research progress and treatment status of malignant ascites DOI Creative Commons
Jing He, Huiping Zhang

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Dec. 16, 2024

Malignant ascites (MA), a common and serious complication of various cancers in the abdominal cavity, originates from extensive infiltration, metastasis, growth cancer cells or on leading to abnormal accumulation fluid cavity formation MA. MA seriously reduces quality life patients, shortens their survival period, generally has poor prognosis. Modern medicine developed strategies for treatment MA, including targeted supportive treatment, diuretic paracentesis, surgical intervention, intraperitoneal administration therapy. Among them, chemotherapy, as one important methods, includes both systemic chemotherapy especially pressurized aerosol (PIPAC), hyperthermic (HIPEC), foam-based (FBIC), providing new choice In addition, innovative methods such gas-based intra-abdominal hyperthermia (GIH) combined with dehydration therapy have also shown promising application prospects. This article delves into multiple aspects its concept, mechanism occurrence, clinical manifestations, differential diagnostic current status research progress. comprehensive review aims provide valuable references effectively controlling improving patients' life, prolonging cycle patients practice. (MA) is cancer, which peritoneum, peritoneal fluid. It manifestation late stage cancer. Its symptoms are stubborn recurrent, can lead pain, bloating, appetite, fatigue, breathing difficulties, even organ failure. The median time 5 6 months. prognosis poor, it imperative seek more active effective plans. reviews aiming certain value patients.

Language: Английский

Citations

0