Published: Oct. 18, 2024
Language: Английский
Translational Oncology, Journal Year: 2024, Volume and Issue: 45, P. 101961 - 101961
Published: April 17, 2024
Tumor microenvironment is an intricate web of stromal and immune cells creating suppressive cordon around the tumor. In hepatocellular carcinoma (HCC), a formidable barrier towards novel therapeutic approaches recently evading oncology field. this study, main aim was to identify evasion tactics mediated by HCC study epigenetic modulation checkpoints; Programmed death-1 (PD-1)/ death-Ligand 1 (PD-L1) T cell immunoreceptor with Ig ITIM domains (TIGIT)/Cluster Differentiation 155 (CD155) at tumor-immune synapse. Thus, liver tissues, PBMCs sera were collected from Hepatitis C Virus (HCV), as well healthy individuals. Screening performed PD-L1/PD-1 CD155/TIGIT axes in patients. PDL1, CD155, PD-1 TIGIT found be significantly upregulated tissues peripheral blood mononuclear (PBMCs) An array long non-coding RNAs (lncRNAs) microRNAs validated regulate such checkpoints screened. The lncRNAs; CCAT-1, H19, MALAT-1 all sera, PBMCs, patients compared HCV controls. However, miR-944-5p, miR-105-5p, miR-486-5p, miR-506-5p, miR-30a-5p downregulated On tumor side, knocking down lncRNAs-CCAT-1, MALAT-1, or H19-markedly repressed co-expression PD-L1 CD155 accordingly induced cytotoxicity co-cultured primary cells. ectopic expression under-expressed microRNAs; decreased transcript levels no effect on TIGIT. other hand, miR-944-5p miR-105-5p dramatically reduced Finally, studied miRNAs enhanced cytotoxic effects against Huh7 showed highest augmentation for conclusion, highlights co-targeting strategy using mimics, CCAT-1 H19 siRNAs efficiently hampers properties HCC.
Language: Английский
Citations
11
Cells, Journal Year: 2024, Volume and Issue: 13(15), P. 1245 - 1245
Published: July 24, 2024
Circular RNAs (circRNAs) are cardinal players in numerous physiological and pathological processes. CircRNAs play dual roles as tumor suppressors oncogenes different oncological contexts, including hepatocellular carcinoma (HCC). Their significantly impact the disease at all stages, initiation, development, progression, invasion, metastasis, addition to response treatment. In this review, we discuss biogenesis regulatory functional of circRNAs, well circRNA-protein-mRNA ternary complex formation, elucidating intricate pathways tuned by circRNAs modulate gene expression cellular processes through a comprehensive literature search, silico bioinformatics analysis. With particular focus on interplay between epigenetics, HCC pathology, article sets stage for further exploration novel investigational theranostic agents dynamic realm HCC.
Language: Английский
Citations
9
Translational Oncology, Journal Year: 2025, Volume and Issue: 54, P. 102329 - 102329
Published: Feb. 26, 2025
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: April 2, 2025
Maternally expressed gene 3 (MEG3), a long non-coding RNA, plays pivotal role in various biological processes, including tumorigenesis. Aberrant expression of MEG3 has been implicated several cancers, genitourinary malignancies. This comprehensive review explores the multifaceted functions context cancers through unravelling molecular mechanisms underlying influence on cellular proliferation, apoptosis, invasion, and metastasis. Additionally, we discuss potential clinical implications as biomarker therapeutic target cancers. By unraveling intricate these this aims to contribute development novel strategies for diagnosis treatment
Language: Английский
Citations
0
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 263, P. 155638 - 155638
Published: Oct. 5, 2024
Language: Английский
Citations
3
Published: Oct. 18, 2024
Language: Английский
Citations
0