Advances in the diagnosis and treatment of MET-variant digestive tract tumors DOI
Chen Zhang, Hui Dong, Jianming Gao

et al.

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(11), P. 4338 - 4353

Published: Oct. 25, 2024

The receptor tyrosine kinase encoded by the MET gene plays an important role in various cellular processes such as growth, survival, migration and angiogenesis, its abnormal activation is closely related to occurrence development of tumors. This article reviews recent advances diagnosis treatment MET-variant digestive tract In terms diagnosis, application next-generation sequencing technology liquid biopsy makes detection variants more accurate efficient, providing a reliable basis for individualized treatment. treatment, inhibitors crizotinib cabotinib have shown good efficacy clinical trials. addition, combination immunotherapy also demonstrated potential synergies, further improving therapeutic effect. However, complexity heterogeneity drug resistance mechanisms are still one difficulties current research. future, it necessary deepen understanding mechanism variation explore new strategies improve overall survival rate quality life patients. tumors moving towards precision individualization, broad prospects.

Language: Английский

A novel high‐risk model identified by epithelial–mesenchymal transition predicts prognosis and radioresistance in rectal cancer DOI
Feiyu Qin, Zehua Bian,

Lingzhen Jiang

et al.

Molecular Carcinogenesis, Journal Year: 2024, Volume and Issue: 63(11), P. 2119 - 2132

Published: July 26, 2024

Many studies have shown that tumor cells survive radiotherapy are more likely to metastasize, but the underlying mechanism remains unclear. Here we aimed identify epithelial-mesenchymal transition (EMT)-related key genes, which associated with prognosis and radiosensitivity in rectal cancer. First, obtained differentially expressed genes by analyzing RNA expression profiles of cancer retrieved from The Cancer Genome Atlas database, EMT-related radiotherapy-related databases, respectively. Then, Lasso Cox regression analyses were used establish an model (EMTPM) based on identified independent protective factor Fibulin5 (FBLN5) risk gene EHMT2. high-EMTPM group exhibited significantly poorer prognosis. evaluated signature external clinical validation cohort. Through vivo experiments, further demonstrated EMTPM effectively distinguishes radioresistant radiosensitive patients Moreover, individuals showed increased immune checkpoints compared their counterparts. Finally, pan-cancer analysis also indicated its potential for predicting lung squamous cell carcinoma breast undergoing radiotherapy. In summary, established a novel predictive radioresistance FBLN5 EHMT2 expressions, suggested microenvironment may be involved process radioresistance. This could select management strategies

Language: Английский

Citations

4
Blood TCTP as a potential biomarker associated with immunosuppressive features and poor clinical outcomes in metastatic gastric cancer DOI Creative Commons
Hyung‐Don Kim, Seyoung Jung, Yeong Hak Bang

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(3), P. e010455 - e010455

Published: March 1, 2025

Background No established biomarker exists for specific myeloid cell populations or in gastric cancer. This study aimed to explore the prognostic and immunological relevance of plasma translationally controlled tumor protein (TCTP) patients with advanced cancer treated an immune checkpoint inhibitor and/or cytotoxic chemotherapy. Methods Plasma samples were prospectively collected from cohorts first-line fluoropyrimidine plus platinum chemotherapy (n=143, cohort 1) third-line nivolumab (n=165, 2). TCTP levels quantified using ELISA, multiplex proteomic analysis (Olink) was conducted assess expression immune-related proteins. External single-cell RNA sequencing (scRNA-seq) spatial transcriptomics datasets employed validate findings. Results Patients high (TCTP-high group) exhibited poor progression-free survival (PFS) overall (OS) compared those low (TCTP-low 1 (HR: 1.73 PFS; 1.77 OS). In TCTP-high group, proteins associated immunosuppressive cells, angiogenesis, exclusion T/natural killer (NK) function upregulated, whereas involved T-cell activation/exhaustion significantly upregulated TCTP-low group. scRNA-seq analyses identified a subset TPT1 (encoding TCTP) TCTP-related molecules, enriched inhibitory inflammation gene signatures providing signals T/NK cells (Macrophage-chemokine). Spatial revealed tumor-cell-enriched cluster co-localized Macrophage-chemokine subset, which highest positive correlation between its abundance average levels. nivolumab-treated (cohort 2), group outcomes 1.39 1.47 Conclusions is biomarker, reflecting clinically relevant

Language: Английский

Citations

0
Identification and validation of matrix metalloproteinase hub genes as potential biomarkers for Skin Cutaneous Melanoma DOI Creative Commons
Zhongyi Zhang, Mei Zhao, Zubing Zhou

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Oct. 18, 2024

Objectives The role of matrix metalloproteinases (MMPs) in Skin Cutaneous Melanoma (SKCM) development and progression is unclear so far. This comprehensive study delved into the intricate MMPs SKCM progression. Methods RT-qPCR, bisulfite sequencing, WES analyzed MMP gene expression, promoter methylation, mutations cell lines. TCGA datasets validated findings. DrugBank molecular docking identified potential regulatory drugs, line experiments confirmed key genes tumorigenesis. Results Our findings unveiled significant up-regulation MMP9, MMP12, MMP14, MMP16, coupled with hypomethylation their promoters lines, implicating involvement disease Mutational analysis highlighted a low frequency these genes, indicating less expression mechanisms. Prognostic assessments showcased correlation between elevated poor overall survival (OS) patients. Additionally, functional involving silencing revealed impact on cellular proliferation, further emphasizing significance MMP16 pathobiology. Conclusion identifies Estradiol Calcitriol as drugs for modulating SKCM, highlighting diagnostic prognostic biomarkers.

Language: Английский

Citations

1
PPIC-labeled CAFs: Key players in neoadjuvant chemotherapy resistance for gastric cancer DOI Creative Commons

Honghao Yin,

Lili Sun,

Yuan Yuan

et al.

Translational Oncology, Journal Year: 2024, Volume and Issue: 48, P. 102080 - 102080

Published: Aug. 7, 2024

Gastric cancer (GC) is the fourth leading cause of deaths, with advanced cases having a median survival less than one year. Neoadjuvant chemotherapy (NCT) vital but faces drug resistance issues, partly due to cancer-associated fibroblasts (CAFs). Yet, specific CAF subpopulations contributing are poorly understood.

Language: Английский

Citations

0
Advances in the diagnosis and treatment of MET-variant digestive tract tumors DOI
Chen Zhang, Hui Dong, Jianming Gao

et al.

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(11), P. 4338 - 4353

Published: Oct. 25, 2024

The receptor tyrosine kinase encoded by the MET gene plays an important role in various cellular processes such as growth, survival, migration and angiogenesis, its abnormal activation is closely related to occurrence development of tumors. This article reviews recent advances diagnosis treatment MET-variant digestive tract In terms diagnosis, application next-generation sequencing technology liquid biopsy makes detection variants more accurate efficient, providing a reliable basis for individualized treatment. treatment, inhibitors crizotinib cabotinib have shown good efficacy clinical trials. addition, combination immunotherapy also demonstrated potential synergies, further improving therapeutic effect. However, complexity heterogeneity drug resistance mechanisms are still one difficulties current research. future, it necessary deepen understanding mechanism variation explore new strategies improve overall survival rate quality life patients. tumors moving towards precision individualization, broad prospects.

Language: Английский

Citations

0