Published: Jan. 1, 2025
Language: Английский
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2025, Volume and Issue: 1880(2), P. 189281 - 189281
Published: Feb. 8, 2025
Language: Английский
Citations
2
Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 422 - 422
Published: Feb. 10, 2025
The intricate relationship between anticancer drugs and the gut microbiome influences cancer treatment outcomes. This review paper focuses on role of integrity in enhancing efficacy safety drug therapy, emphasizing pharmacokinetic interactions microbiota. It explores how disruptions to composition, or dysbiosis, can alter metabolism, immune responses, side effects. By examining mechanisms disruption caused by drugs, this highlights specific case studies like cyclophosphamide, 5-fluorouracil, irinotecan, their impact microbial diversity clinical also discusses microbiome-targeted strategies, including prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), as promising interventions enhance treatment. Furthermore, potential profiling personalizing therapy integrating these into practice is explored. Finally, proposes future research directions, developing novel biomarkers a deeper comprehension drug-microbiome interactions, respond current gaps knowledge improve patient outcomes care.
Language: Английский
Citations
1
Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270
Published: Feb. 12, 2025
The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.
Language: Английский
Citations
1
Journal of Cellular Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: April 12, 2025
The gut microbiota, consisting of trillions microorganisms residing in the gastrointestinal tract, has a profound influence on various aspects human health, including genetics and metabolism. Far from being passive passengers, these engage complex, bidirectional relationship with host, modulating gene expression metabolic processes. Emerging evidence reveals that microbiota can affect host genetic pathways, such as those involved immune responses inflammation. Moreover, plays pivotal role regulation, influencing processes like energy balance, fat storage, glucose Disruptions this delicate known dysbiosis, have been linked to disorders obesity, diabetes, cardiovascular diseases. This review delves into ways interacts metabolism, exploring key topics microbial modulation expression, microbiota’s impact implications for personalized medicine. Additionally, it highlights therapeutic potential targeting microbiome prevent treat Through better understanding intricate relationships, we unlock new strategies improve health well-being.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0