The Role of Reactive Oxygen Species in Colorectal Cancer Initiation and Progression: Perspectives on Theranostic Approaches DOI Open Access

Teresa Catalano,

Federico Selvaggi, Roberto Cotellese

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 752 - 752

Published: Feb. 22, 2025

Altered levels of reactive oxygen species (ROS) are recognized as one the key factors in mediating tumor cell survival tissue microenvironment, where they play a role initiation, progression and recurrence/relapse colorectal cancer (CRC). Tumor cells can adapt to oxidative stress (OS) using genetic or metabolic reprogramming long short term. In addition, defend themselves through positive regulation antioxidant molecules, enhancing ROS-driven proliferation. Balanced eustress influence chemotherapy resistance, allowing survive treatment. Secondary effects include increased ROS production redox stress, which kill eliminate drug resistance. Anticancer treatments based on manipulating could represent gold standard CRC therapy. Therefore, exploring modulation response OS deregulated signaling pathways may lead development new personalized overcome therapy this review, we explore initiation their diagnostic implications biomarkers disease. Furthermore, focused involvement different therapeutic options, such surgery, radiotherapy, theranostic imaging, immunotherapy other precision medicine approaches.

Language: Английский

The Role of Reactive Oxygen Species in Colorectal Cancer Initiation and Progression: Perspectives on Theranostic Approaches DOI Open Access

Teresa Catalano,

Federico Selvaggi, Roberto Cotellese

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 752 - 752

Published: Feb. 22, 2025

Altered levels of reactive oxygen species (ROS) are recognized as one the key factors in mediating tumor cell survival tissue microenvironment, where they play a role initiation, progression and recurrence/relapse colorectal cancer (CRC). Tumor cells can adapt to oxidative stress (OS) using genetic or metabolic reprogramming long short term. In addition, defend themselves through positive regulation antioxidant molecules, enhancing ROS-driven proliferation. Balanced eustress influence chemotherapy resistance, allowing survive treatment. Secondary effects include increased ROS production redox stress, which kill eliminate drug resistance. Anticancer treatments based on manipulating could represent gold standard CRC therapy. Therefore, exploring modulation response OS deregulated signaling pathways may lead development new personalized overcome therapy this review, we explore initiation their diagnostic implications biomarkers disease. Furthermore, focused involvement different therapeutic options, such surgery, radiotherapy, theranostic imaging, immunotherapy other precision medicine approaches.

Language: Английский

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