Sleep-wake states are encoded across emotion-regulation regions of the mouse brain DOI Creative Commons
Kathryn K. Walder-Christensen, Jack Goffinet, Alexandra L. Bey

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 15, 2024

Abstract Emotional dysregulation is highly comorbid with sleep disturbances. Sleep comprised of unique physiological states that are reflected by conserved brain oscillations. Though the role these state-dependent oscillations in cognitive function has been well established, less known regarding nature across regions strongly contribute to emotional function. To characterize dynamics, we recorded local field potentials simultaneously from multiple cortical and subcortical implicated emotion-regulation widespread patterns spectral power synchrony between during sleep/wake states. First, showed encode state, albeit various degrees accuracy. We then identified network-based classifiers based on combination features all regions. Spectral networks allowed for automatic, accurate rapid discrimination wake, non-REM (NREM) eye movement (REM) sleep. When examined impact commonly prescribed promoting medications neural dynamics regions, found disparate alterations both activity three Finally, a stress manipulation disrupts circadian rhythm produced increased fragmentation without altering underlying average sleep-wake Thus, characterized state dependent canonically associated emotions. Significance Statement emotion regulation be intertwined at level behavior neuropsychiatric illnesses. Here, how involved wake performing multi-site electrophysiological recordings mice. developed rapidly labeled alone. sleep-inducing have impacts throughout explored disruption architecture activity. Together, data shed light which regulate behave so one day, treatments improve well-being may developed.

Language: Английский

Making sense of feelings DOI Creative Commons
Brian Key, Deborah Brown

Neuroscience of Consciousness, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Abstract Internal feeling states such as pain, hunger, and thirst are widely assumed to be drivers of behaviours essential for homeostasis animal survival. Call this the ‘causal assumption’. It is becoming increasingly apparent that causal assumption incompatible with standard view motor action in neuroscience. While there a well-known explanatory gap between neural activity feelings, also disjuncture reverse direction—what role, if any, do feelings play animals not cause behaviour? To deny might thus seem presage epiphenomenalism—the idea subjective experiences, including inert, emergent and, on some views, non-physical properties brain processes. Since epiphenomenalism antagonistic fundamental commitments evolutionary biology, developed here challenges about function without denying have function. Instead, we introduce ‘sense making sense’ hypothesis—the experience behaviour, but explain, restricted still useful sense ‘explanation’. A plausible framework derived integrates commonly accepted computations blend control, processes make way integrated into our how why what do.

Language: Английский

Citations

1
A widespread electrical brain network encodes anxiety in health and depressive states DOI
Dalton Hughes,

Michael Hunter Klein,

Kathryn K. Walder-Christensen

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 30, 2024

Abstract In rodents, anxiety is charactered by heightened vigilance during low-threat and uncertain situations. Though activity in the frontal cortex limbic system are fundamental to supporting this internal state, underlying network architecture that integrates across brain regions encode animals paradigms remains unclear. Here, we utilize parallel electrical recordings freely behaving mice, translational known induce anxiety, machine learning discover a multi-region encodes anxious brain-state. The composed of circuits widely implicated behavior, it generalizes many behavioral contexts fails multiple do not. Strikingly, also principally altered two mouse models depression. Thus, establish network-level process whereby health disease.

Language: Английский

Citations

0
Sleep-wake states are encoded across emotion-regulation regions of the mouse brain DOI Creative Commons
Kathryn K. Walder-Christensen, Jack Goffinet, Alexandra L. Bey

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 15, 2024

Abstract Emotional dysregulation is highly comorbid with sleep disturbances. Sleep comprised of unique physiological states that are reflected by conserved brain oscillations. Though the role these state-dependent oscillations in cognitive function has been well established, less known regarding nature across regions strongly contribute to emotional function. To characterize dynamics, we recorded local field potentials simultaneously from multiple cortical and subcortical implicated emotion-regulation widespread patterns spectral power synchrony between during sleep/wake states. First, showed encode state, albeit various degrees accuracy. We then identified network-based classifiers based on combination features all regions. Spectral networks allowed for automatic, accurate rapid discrimination wake, non-REM (NREM) eye movement (REM) sleep. When examined impact commonly prescribed promoting medications neural dynamics regions, found disparate alterations both activity three Finally, a stress manipulation disrupts circadian rhythm produced increased fragmentation without altering underlying average sleep-wake Thus, characterized state dependent canonically associated emotions. Significance Statement emotion regulation be intertwined at level behavior neuropsychiatric illnesses. Here, how involved wake performing multi-site electrophysiological recordings mice. developed rapidly labeled alone. sleep-inducing have impacts throughout explored disruption architecture activity. Together, data shed light which regulate behave so one day, treatments improve well-being may developed.

Language: Английский

Citations

0