Beyond the three-chamber test: toward a multimodal and objective assessment of social behavior in rodents

Molecular Autism, Journal Year: 2022, Volume and Issue: 13(1)

Published: Oct. 25, 2022

Abstract Main In recent years, substantial advances in social neuroscience have been realized, including the generation of numerous rodent models autism spectrum disorder. Still, it can be argued that those methods currently being used to analyze animal behavior create a bottleneck significantly slows down progress this field. Indeed, bulk research still relies on small number simple behavioral paradigms, results which are assessed without considering dynamics. Moreover, only few variables examined each paradigm, thus overlooking significant portion complexity characterizes interaction between two conspecifics, subsequently hindering our understanding neural mechanisms governing different aspects behavior. We further demonstrate these constraints by discussing most commonly paradigm for assessing behavior, three-chamber test. also point fact although emotions greatly influence human we lack reliable means emotional state animals during tasks. As such, discuss current evidence supporting existence pro-social and cognition models. suggest adequate analysis requires novel multimodal approach employs automated simultaneous measurements multiple physiological at high temporal resolution socially interacting animals. accordingly describe several computerized systems computational tools acquiring analyzing such measurements. Finally, address assess socio-emotional states elucidate intricacies so as attain deeper insight into brain mediate behaviors. Conclusions summary, combining with machine-learning algorithms will help define determine their dynamics various types tasks, enabling more thorough

Language: Английский

---

Implication of the social function of excessive self-grooming behavior in BTBR T+ltpr3tf/J mice as an idiopathic model of autism

Physiology & Behavior, Journal Year: 2021, Volume and Issue: 237, P. 113432 - 113432

Published: April 23, 2021

Autism spectrum disorder (ASD) is defined by two core behavioral characteristics, namely, restricted repetitive behaviors and impaired social-communicative functioning. BTBR T+ltpr3tf/J (BTBR) mice provide a valuable animal model for ASD to elucidate the underlying mechanisms of these characteristics ASD. This study examined social function excessive grooming behavior in as phenotype behaviors. Compared control C57BL/6 J (B6) strain, showed increased self-grooming when placed alone test apparatus, this was even more evident confronted with stimulus mouse (either B6 or BTBR) three-chamber apparatus. While tended groom their face/snout region on empty side chamber, frequent transitions among body regions chamber containing stimulus. Acute systemic injection buspirone,a serotonin 1A receptor agonist, an anxiolytic, facilitated approach toward stimuli setting both mice. However, treatment did not affect significantly enhanced These suggest potential signaling response stimuli, which bodywide expressed proximity opponents may stimulate release olfactory (possibly dismissive) signals. Consequently, putative neural differ from those regulating approaches that are associated anxiolytic mechanisms.

Language: Английский

---

Social factors and the neurobiology of pathogen avoidance

Biology Letters, Journal Year: 2022, Volume and Issue: 18(2)

Published: Feb. 1, 2022

Although the evolutionary causes and consequences of pathogen avoidance have been gaining increasing interest, there has less attention paid to proximate neurobiological mechanisms. Animals gauge infection status conspecifics threat they represent on basis various sensory social cues. Here, we consider neurobiology detection from a cognitive, motivational affective state (disgust) perspective, focusing mechanisms associated with activating directing parasite/pathogen avoidance. Drawing upon studies laboratory rodents, briefly discuss aspects (i) olfactory-mediated recognition infected conspecifics; (ii) relationships between factors (e.g. vigilance, distancing (approach/avoidance), salience reward); (iii) roles brain regions (in particular amygdala insular cortex) neuromodulators (neurotransmitters, neuropeptides, steroidal hormones immune components) in regulation We propose that understanding can provide insights into ecological non-consumptive effects pathogens how, when why females males engage

Language: Английский

---

Multi-dimensional social relationships shape social attention in monkeys

Published: Jan. 6, 2025

Social relationships guide individual behavior and ultimately shape the fabric of society. Primates exhibit particularly complex, differentiated, multidimensional social relationships, which form interwoven networks, reflecting both tendencies specific dyadic interactions. How patterns that underlie these emerge from moment-to-moment information processing remains unclear. Here, we assess among a group four monkeys, focusing on aggression, grooming, proximity. We show differences in attention vary with general engagement partners. Oxytocin administration altered its relationship to grooming aggression. Our findings link dynamics visual sampling primate networks.

Language: Английский

---

Multi-dimensional social relationships shape social attention in monkeys

eLife, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Social relationships guide individual behavior and ultimately shape the fabric of society. Primates exhibit particularly complex, differentiated, multidimensional social relationships, which form interwoven networks, reflecting both tendencies specific dyadic interactions. How patterns that underlie these emerge from moment-to-moment information processing remains unclear. Here, we assess among a group four monkeys, focusing on aggression, grooming, proximity. We show differences in attention vary with general engagement partners. Oxytocin administration altered its relationship to grooming aggression. Our findings link dynamics visual sampling primate networks.

Language: Английский

---

Multi-dimensional social relationships shape social attention in monkeys

Published: Feb. 26, 2025

Social relationships guide individual behavior and ultimately shape the fabric of society. Primates exhibit particularly complex, differentiated, multidimensional social relationships, which form interwoven networks, reflecting both tendencies specific dyadic interactions. How patterns that underlie these emerge from moment-to-moment information processing remains unclear. Here, we assess among a group four monkeys, focusing on aggression, grooming, proximity. We show differences in attention vary with general engagement partners. Oxytocin administration altered its relationship to grooming aggression. Our findings link dynamics visual sampling primate networks.

Language: Английский

---

Multi-dimensional social relationships shape social attention in monkeys

eLife, Journal Year: 2025, Volume and Issue: 14

Published: March 7, 2025

Social relationships guide individual behavior and ultimately shape the fabric of society. Primates exhibit particularly complex, differentiated, multidimensional social relationships, which form interwoven networks, reflecting both tendencies specific dyadic interactions. How patterns that underlie these emerge from moment-to-moment information processing remains unclear. Here, we assess among a group four monkeys, focusing on aggression, grooming, proximity. We show differences in attention vary with general engagement partners. Oxytocin administration altered its relationship to grooming aggression. Our findings link dynamics visual sampling primate networks.

Language: Английский

---

Dopamine type II receptors in amygdala along with oxytocin in hypothalamus regulate social behavior in male mandarin voles

Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: 250, P. 174002 - 174002

Published: March 24, 2025

Language: Английский

---

Adolescent social isolation disrupts developmental tuning of neuropeptide circuits in the hypothalamus to amygdala regulating social and defensive behavior

Peptides, Journal Year: 2024, Volume and Issue: 175, P. 171178 - 171178

Published: Feb. 16, 2024

Language: Английский

---

The posterior intralaminar thalamic nucleus promotes nose‐to‐nose contacts leading to prosocial reception in the sequence of mouse social interaction

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: 60(7), P. 5731 - 5749

Published: Aug. 29, 2024

Efficient social interaction is essential for an adaptive life and consists of sequential processes multisensory events with counterparts. Social touch/contact a unique component that promotes sequence behaviours initiated by detection approach to assess stimulus subsequent form prosocial relationships. We hypothesized the thalamic sensory relay circuit from posterior intralaminar nucleus thalamus (pIL) paraventricular hypothalamus (PVN) medial amygdala (MeA) plays key role in contact-mediated events. found neurons pIL along PVN MeA were activated encounters activity was more abundant direct physical encounter, whereas dominant indirect through grid encounter. Chemogenetic inhibition selectively decreased investigatory sniffing same-sex, but not opposite-sex, mouse encounter situation facial/snout contact ratio setting. Furthermore, chemogenetic had no impact on anxiety-like or body coordinative motor behaviours, it impaired whisker-related plantar touch tactile sense. propose can sensations mediate nonsexual interactions thus significant establishing relationships models.

Language: Английский

---