Isolation, characterization, and transcriptome profiling of umbilical cord mesenchymal stem cells in pigs DOI

Bienvenu Odjoubiré Mahougnon Koutonin,

Fuyao Zhang,

Yuan Jiang

et al.

Published: Jan. 1, 2024

Language: Английский

Intranasal administration of stem cell-derived exosome alleviates cognitive impairment against subarachnoid hemorrhage DOI Creative Commons
S Gotoh, Masahito Kawabori, Sho Yamaguchi

et al.

Experimental Neurology, Journal Year: 2025, Volume and Issue: 386, P. 115143 - 115143

Published: Jan. 11, 2025

Language: Английский

Citations

0
Identifying TNFSF4low-MSCs superiorly treating idiopathic pulmonary fibrosis through Tregs differentiation modulation DOI Creative Commons
Yuanyuan Xie,

Qing Yi,

Congwang Xu

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 20, 2025

Idiopathic pulmonary fibrosis is a progressive lung disorder, presenting clinically with symptoms such as shortness of breath and hypoxemia. Despite its severe prognosis limited treatment options, the pathogenesis idiopathic remains poorly understood. This study aims to investigate therapeutic potential mesenchymal stromal cells in treating fibrosis, focusing on their ability modulate regulatory T through low tumor necrosis factor superfamily member 4 (TNFSF4) pathway. The goal identify subtypes optimal immunomodulatory effects enhance functions ameliorate fibrosis. We identified immune characteristics by mining analyzing multiple public datasets detecting blood tissues patients. An extensive examination followed, including assessing impact proportions peripheral tissue, exploring specific role TNFSF4 expression modulation. Whole-genome sequencing cluster analysis were used expression. Mesenchymal characterized (TNFSF4low-MSCs) demonstrated enhanced regulate subpopulations exhibited pronounced anti-fibrotic bleomycin-induced mouse model. These increased proportions, reduced improved survival rates. TNFSF4-tumor receptor (TNFRSF4) signaling was critical pathway influencing generation function. Our findings underscore pivotal mediated modulation highlight selecting based for approach may offer novel avenue development targeted therapies aimed at modulating responses ameliorating involved collecting 10 mL from patients, Medical Ethics Committee Nanjing Drum Tower Hospital approved our protocol approval number 2023-675-01.

Language: Английский

Citations

0
Cryopreservation of mesenchymal stem/stromal cells using a DMSO-free solution is comparable to DMSO-containing cryoprotectants: results of an international multicenter PACT/BEST collaborative study DOI
Tewodros Mamo, Cheryl A. Cox,

Connor Demorest

et al.

Cytotherapy, Journal Year: 2024, Volume and Issue: 26(12), P. 1522 - 1531

Published: July 6, 2024

Language: Английский

Citations

1
Isolation, characterization, and transcriptome profiling of umbilical cord mesenchymal stem cells in pigs DOI

Bienvenu Odjoubiré Mahougnon Koutonin,

Fuyao Zhang,

Yuan Jiang

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0