Towards a Better Understanding of the Human Health Risk of Per- and Polyfluoroalkyl Substances Using Organoid Models DOI Creative Commons
Haiyan Xu,

Jiahui Kang,

Xue Gao

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 393 - 393

Published: April 7, 2025

The ubiquitous presence of per- and polyfluoroalkyl substances (PFAS) in the environment has garnered global public concern. Epidemiological studies have proved that exposure to PFAS is associated with human health risks. Although evidence demonstrated toxic mechanisms based on animal models traditional cell cultures, their limitations inter-species differences lack human-relevant microenvironments hinder understanding risks from exposure. There an increasing necessity explore alternative methodologies can effectively evaluate Human organoids derived stem cells accurately mimic sophisticated multicellular structures native organs, providing promising for toxicology research. Advanced combined innovative technologies are expected improve breadth depth toxicity.

Language: Английский

Towards a Better Understanding of the Human Health Risk of Per- and Polyfluoroalkyl Substances Using Organoid Models DOI Creative Commons
Haiyan Xu,

Jiahui Kang,

Xue Gao

et al.

Bioengineering, Journal Year: 2025, Volume and Issue: 12(4), P. 393 - 393

Published: April 7, 2025

The ubiquitous presence of per- and polyfluoroalkyl substances (PFAS) in the environment has garnered global public concern. Epidemiological studies have proved that exposure to PFAS is associated with human health risks. Although evidence demonstrated toxic mechanisms based on animal models traditional cell cultures, their limitations inter-species differences lack human-relevant microenvironments hinder understanding risks from exposure. There an increasing necessity explore alternative methodologies can effectively evaluate Human organoids derived stem cells accurately mimic sophisticated multicellular structures native organs, providing promising for toxicology research. Advanced combined innovative technologies are expected improve breadth depth toxicity.

Language: Английский

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