Convergent Mechanisms in Virus-Induced Cancers: A Perspective on Classical Viruses, SARS-CoV-2, and AI-Driven Solutions DOI Creative Commons

Thorsten Rudroff

Infectious Disease Reports, Journal Year: 2025, Volume and Issue: 17(2), P. 33 - 33

Published: April 16, 2025

This perspective examines the potential oncogenic mechanisms of SARS-CoV-2 through comparative analysis with established cancer-causing viruses, integrating classical virological approaches artificial intelligence (AI)-driven analysis. The paper explores four key themes: shared between viruses and (including cell cycle dysregulation, inflammatory signaling, immune evasion, metabolic reprogramming); application AI in understanding viral oncogenesis; integration neuroimaging evidence; future research directions. author presents novel hypotheses regarding SARS-CoV-2’s mechanisms, supported by recent PET/FDG imaging studies showing persistent alterations. manuscript emphasizes transformative combining traditional methods advanced technologies for better preventing virus-induced cancers, while highlighting importance long-term monitoring COVID-19 survivors developments.

Language: Английский

The relationship between ferroptosis and respiratory infectious diseases: a novel landscape for therapeutic approach DOI Creative Commons

Hong Lin,

Xiangyu Chen, Yiming Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 18, 2025

Respiratory infectious diseases, particularly those caused by respiratory viruses, have the potential to lead global pandemics, thereby posing significant threats public and human health. Historically, primary treatment for bacterial infections has been antibiotic therapy, while severe cases of viral predominantly managed controlling inflammatory cytokine storms. Ferroptosis is a novel form programmed cell death that distinct from apoptosis autophagy. In recent years, Recent studies demonstrated ferroptosis plays regulatory role in various indicating targeting may represent approach these conditions. This article summarized toxic mechanisms underlying ferroptosis, its relationship with action, current strategies. Particular attentions were given interplay between Mycobacterium tuberculosis, Epstein-Barr virus, acute syndrome coronavirus-2, Pseudomonas aeruginosa, dengue influenza virus herpes simplex type1infection. A deeper understanding will not only advance our knowledge infection-related pathophysiology but also provide theoretical foundation development therapeutic Targeting pathways represents promising infections, clinical translational implications.

Language: Английский

Citations

0
The reactivation of the various types of viruses following COVID-19 infection: a systematic review DOI
Maziar Naderi,

Majid Naderi,

Mostofa Jamal

et al.

Future Virology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: March 27, 2025

Language: Английский

Citations

0
Convergent Mechanisms in Virus-Induced Cancers: A Perspective on Classical Viruses, SARS-CoV-2, and AI-Driven Solutions DOI Creative Commons

Thorsten Rudroff

Infectious Disease Reports, Journal Year: 2025, Volume and Issue: 17(2), P. 33 - 33

Published: April 16, 2025

This perspective examines the potential oncogenic mechanisms of SARS-CoV-2 through comparative analysis with established cancer-causing viruses, integrating classical virological approaches artificial intelligence (AI)-driven analysis. The paper explores four key themes: shared between viruses and (including cell cycle dysregulation, inflammatory signaling, immune evasion, metabolic reprogramming); application AI in understanding viral oncogenesis; integration neuroimaging evidence; future research directions. author presents novel hypotheses regarding SARS-CoV-2’s mechanisms, supported by recent PET/FDG imaging studies showing persistent alterations. manuscript emphasizes transformative combining traditional methods advanced technologies for better preventing virus-induced cancers, while highlighting importance long-term monitoring COVID-19 survivors developments.

Language: Английский

Citations

0