Impact of Serum Adiponectin Level on Insulin and hs-CRP in Patients with Type 2 Diabetes: A Case-Control Study DOI

Hind Jawad,

Hatem Ali,

Mustafa Jawad

et al.

Published: March 19, 2025

Introduction: Type 2 diabetes mellitus (T2DM) is marked by insulin resistance, hyperglycemia, and systemic inflammation. Adiponectin—a hormone produced mainly adipose tissue—enhances sensitivity exhibits anti‐inflammatory properties. This study evaluated serum adiponectin related metabolic markers in Iraqi patients with T2DM versus healthy controls. Methods: In a case-control design, 84 subjects were recruited (45 39 controls). Fasting blood samples obtained to measure adiponectin, insulin, high-sensitivity C-reactive protein (hs-CRP), fasting glucose (FSG), Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) using standardized ELISA biochemical assays. Correlations between anthropometric parameters also analyzed. Results: Controls showed significantly higher levels (p < 0.05) compared T2DM. contrast, hs-CRP, FSG, HOMA-IR elevated the diabetic group 0.05). Moreover, demonstrated significant negative correlations both height weight among controls, their lower body suggesting enhanced fatty acid oxidation. Conclusions: These findings indicate that associated improved reduced inflammatory markers. The data support potential role of mitigating overweight risks T2DM, warranting further investigation into its therapeutic utility.

Language: Английский

Impact of Serum Adiponectin Level on Insulin and hs-CRP in Patients with Type 2 Diabetes: A Case-Control Study DOI

Hind Jawad,

Hatem Ali,

Mustafa Jawad

et al.

Published: March 19, 2025

Introduction: Type 2 diabetes mellitus (T2DM) is marked by insulin resistance, hyperglycemia, and systemic inflammation. Adiponectin—a hormone produced mainly adipose tissue—enhances sensitivity exhibits anti‐inflammatory properties. This study evaluated serum adiponectin related metabolic markers in Iraqi patients with T2DM versus healthy controls. Methods: In a case-control design, 84 subjects were recruited (45 39 controls). Fasting blood samples obtained to measure adiponectin, insulin, high-sensitivity C-reactive protein (hs-CRP), fasting glucose (FSG), Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) using standardized ELISA biochemical assays. Correlations between anthropometric parameters also analyzed. Results: Controls showed significantly higher levels (p < 0.05) compared T2DM. contrast, hs-CRP, FSG, HOMA-IR elevated the diabetic group 0.05). Moreover, demonstrated significant negative correlations both height weight among controls, their lower body suggesting enhanced fatty acid oxidation. Conclusions: These findings indicate that associated improved reduced inflammatory markers. The data support potential role of mitigating overweight risks T2DM, warranting further investigation into its therapeutic utility.

Language: Английский

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