Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies DOI Creative Commons
Chiara Giorgi, Francesca Lombardi, Francesca Rosaria Augello

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 657 - 657

Published: May 2, 2025

Breast and ovarian cancers are among the most prevalent in women. Cancerous cells characterized by their ability to continuously cycle migrate, forming metastases. Some probiotic strains have shown anti-tumorigenic effects. This study tested impact of probiotics on OVCAR-3 MDA-MB-231 cell lines analyzing proteins involved regulation (pP53, Cyclin D1, pERK1), survival (AKT), migration (RhoA) using Western blotting scratch wound tests. Results indicated a reduction these decreased velocity post-treatment. These findings suggest that certain combinations can arrest cycle, promote death, reduce migration, potentially serving as promising candidates alongside standard therapies.

Language: Английский

Probiotics as Anti-Tumor Agents: Insights from Female Tumor Cell Culture Studies DOI Creative Commons
Chiara Giorgi, Francesca Lombardi, Francesca Rosaria Augello

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 657 - 657

Published: May 2, 2025

Breast and ovarian cancers are among the most prevalent in women. Cancerous cells characterized by their ability to continuously cycle migrate, forming metastases. Some probiotic strains have shown anti-tumorigenic effects. This study tested impact of probiotics on OVCAR-3 MDA-MB-231 cell lines analyzing proteins involved regulation (pP53, Cyclin D1, pERK1), survival (AKT), migration (RhoA) using Western blotting scratch wound tests. Results indicated a reduction these decreased velocity post-treatment. These findings suggest that certain combinations can arrest cycle, promote death, reduce migration, potentially serving as promising candidates alongside standard therapies.

Language: Английский

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