Journal of Cell Science,
Journal Year:
2022,
Volume and Issue:
135(6)
Published: March 14, 2022
ABSTRACT
The
tightly
coordinated,
spatiotemporal
control
of
actin
filament
remodeling
provides
the
basis
fundamental
cellular
processes,
such
as
cell
migration
and
adhesion.
Specific
protein
assemblies,
composed
various
actin-binding
proteins,
are
thought
to
operate
in
these
processes
nucleate
elongate
new
filaments,
arrange
them
into
complex
three-dimensional
(3D)
arrays
recycle
replenish
monomer
pool.
Actin
assembly
is
not
only
necessary
generate
pushing
forces
against
leading
edge
membrane
or
propel
pathogens
through
cytoplasm,
but
also
coincides
with
generation
stress
fibers
(SFs)
focal
adhesions
(FAs)
that
generate,
transmit
sense
mechanical
tension.
families
known
date
directly
enhance
elongation
filaments
formins
family
Ena/VASP
proteins.
Their
mechanisms
action,
however,
enhancing
processive
distinct.
aim
this
Review
summarize
our
current
knowledge
on
molecular
Ena/VASP-mediated
assembly,
discuss
recent
insights
biological
functions
proteins
protrusion,
Physiological Reviews,
Journal Year:
2023,
Volume and Issue:
103(2), P. 1247 - 1421
Published: Jan. 5, 2023
This
review
aims
to
survey
the
current
state
of
mechanotransduction
in
vascular
smooth
muscle
cells
(VSMCs)
and
endothelial
(ECs),
including
their
sensing
mechanical
stimuli
transduction
signals
that
result
acute
functional
modulation
longer-term
transcriptomic
epigenetic
regulation
blood
vessels.
The
mechanosensors
discussed
include
ion
channels,
plasma
membrane-associated
structures
receptors,
junction
proteins.
mechanosignaling
pathways
presented
cytoskeleton,
integrins,
extracellular
matrix,
intracellular
signaling
molecules.
These
are
followed
by
discussions
on
transcriptome
epigenetics,
relevance
health
disease,
interactions
between
VSMCs
ECs.
Throughout
this
review,
we
offer
suggestions
for
specific
topics
require
further
understanding.
In
closing
section
conclusions
perspectives,
summarize
what
is
known
point
out
need
treat
vasculature
as
a
system,
not
only
ECs
but
also
matrix
other
types
such
resident
macrophages
pericytes,
so
can
fully
understand
physiology
pathophysiology
vessel
whole,
thus
enhancing
comprehension,
diagnosis,
treatment,
prevention
diseases.
Langmuir,
Journal Year:
2023,
Volume and Issue:
39(10), P. 3546 - 3557
Published: Feb. 27, 2023
Swelling
in
polymer
materials
is
a
ubiquitous
phenomenon.
At
molecular
level,
swelling
dictated
by
solvent-polymer
interactions,
and
has
been
thoroughly
studied
both
theoretically
experimentally.
Favorable
interactions
result
the
solvation
of
chains.
For
polymers
confined
geometries,
such
as
those
that
are
tethered
to
surfaces,
or
for
networks,
can
lead
swelling-induced
tensions.
These
tensions
act
on
chains
stretching,
bending,
deformation
material
at
micro-
macroscopic
scale.
This
Invited
Feature
Article
sheds
light
mechanochemical
phenomena
across
dimensions,
discusses
approaches
visualize
characterize
these
effects.
Physiological Reviews,
Journal Year:
2020,
Volume and Issue:
100(4), P. 1621 - 1705
Published: March 19, 2020
The
urothelium,
which
lines
the
renal
pelvis,
ureters,
urinary
bladder,
and
proximal
urethra,
forms
a
high-resistance
but
adaptable
barrier
that
surveils
its
mechanochemical
environment
communicates
changes
to
underlying
tissues
including
afferent
nerve
fibers
smooth
muscle.
goal
of
this
review
is
summarize
new
insights
into
urothelial
biology
function
have
occurred
in
past
decade.
After
familiarizing
reader
with
key
aspects
histology,
we
describe
development
regeneration.
This
followed
by
an
extended
discussion
function,
information
about
roles
glycocalyx,
ion
water
transport,
tight
junctions,
cellular
tissue
shape
other
adaptations
accompany
expansion
contraction
lower
tract.
We
also
explore
evidence
urothelium
can
alter
solute
composition
urine
during
normal
physiology
response
overdistension.
complete
providing
overview
our
current
knowledge
environment,
discussing
sensor
transducer
functions
exploring
role
circadian
rhythms
gene
expression,
describing
novel
research
tools
are
likely
further
advance
understanding
biology.
