The gut microbiota and depressive symptoms across ethnic groups DOI Creative Commons
Jos A. Bosch, Max Nieuwdorp, Aeilko H. Zwinderman

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Dec. 6, 2022

The gut microbiome is thought to play a role in depressive disorders, which makes it an attractive target for interventions. Both the and symptom levels vary substantially across ethnic groups. Thus, any intervention depression targeting requires understanding of microbiome-depression associations ethnicities. Analysing data from HELIUS cohort, we characterize microbiota its with symptoms 6 groups (Dutch, South-Asian Surinamese, African Ghanaian, Turkish, Moroccan; N = 3211), living same urban area. Diversity microbiota, both within (α-diversity) between individuals (β-diversity), predicts levels, taking into account demographic, behavioural, medical differences. These do not differ Further, β-diversity explains 29%-18% differences symptoms. Bacterial genera associated belong mulitple families, prominently including families Christensenellaceae, Lachnospiraceae, Ruminococcaceae. In summary, results show that are linked this association generalizes Moreover, suggest may partly explain parallel disparities depression.

Language: Английский

Microbiota in health and diseases DOI Creative Commons
Kejun Hou,

Zhuo‐Xun Wu,

Xuan-Yu Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: April 23, 2022

Abstract The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, can be classified into gut, oral, respiratory, skin microbiota. microbial communities are symbiosis with host, contributing to homeostasis regulating immune function. However, dysbiosis lead dysregulation bodily functions including cardiovascular (CVDs), cancers, respiratory diseases, etc. In this review, we discuss current knowledge how links host or pathogenesis. We first summarize research healthy conditions, gut-brain axis, colonization resistance modulation. Then, highlight pathogenesis disease development progression, primarily associated community composition, modulation response, induction chronic inflammation. Finally, introduce clinical approaches that utilize for treatment, such as fecal transplantation.

Language: Английский

Citations

1603
Applying the core microbiome to understand host–microbe systems DOI Creative Commons
Alice Risely

Journal of Animal Ecology, Journal Year: 2020, Volume and Issue: 89(7), P. 1549 - 1558

Published: April 5, 2020

Abstract The host‐associated core microbiome was originally coined to refer common groups of microbes or genes that were likely be particularly important for host biological function. However, the term has evolved encompass variable definitions across studies, often identifying key with respect their spatial distribution, temporal stability ecological influence, as well contribution function and fitness. A major barrier reaching a consensus over how define its relevance biological, evolutionary theory is lack precise terminology associated definitions, persistent association Common, microbiomes can together generate insights into processes act independently function, while functional host‐adapted cores distinguish between facultative near‐obligate symbionts differ in effects on This commentary summarizes five broad have been applied literature, highlighting strengths limitations advancing our understanding host–microbe systems, noting where they are overlap, discussing potential No one definition capture range population. Applied together, reveal different layers microbial organization from which we begin understand govern interactions.

Language: Английский

Citations

289
Microbial evolution and transitions along the parasite–mutualist continuum DOI Creative Commons
Georgia Drew, Emily J. Stevens, Kayla C. King

et al.

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 19(10), P. 623 - 638

Published: April 19, 2021

Virtually all plants and animals, including humans, are home to symbiotic microorganisms. Symbiotic interactions can be neutral, harmful or have beneficial effects on the host organism. However, growing evidence suggests that microbial symbionts evolve rapidly, resulting in drastic transitions along parasite–mutualist continuum. In this Review, we integrate theoretical empirical findings discuss mechanisms underpinning these evolutionary shifts, as well ecological drivers why some host–microorganism may stuck at end of addition having biomedical consequences, understanding dynamic life microorganisms reveals how symbioses shape an organism's biology entire community, particularly a changing world. for organisms. Drew, Stevens King continuum, underlying changes, selective pressures involved common approaches studying them.

Language: Английский

Citations

236
An in vitro batch fermentation protocol for studying the contribution of food to gut microbiota composition and functionality DOI
Sergio Pérez-Burillo, Silvia Molino, Beatriz Navajas-Porras

et al.

Nature Protocols, Journal Year: 2021, Volume and Issue: 16(7), P. 3186 - 3209

Published: June 4, 2021

Language: Английский

Citations

189
Antibiotic perturbations to the gut microbiome DOI
Skye R. S. Fishbein, Bejan Mahmud, Gautam Dantas

et al.

Nature Reviews Microbiology, Journal Year: 2023, Volume and Issue: 21(12), P. 772 - 788

Published: July 25, 2023

Language: Английский

Citations

179
Microbiome diversity protects against pathogens by nutrient blocking DOI
Frances Spragge, Erik Bakkeren, Martin T. Jahn

et al.

Science, Journal Year: 2023, Volume and Issue: 382(6676)

Published: Dec. 14, 2023

The human gut microbiome plays an important role in resisting colonization of the host by pathogens, but we lack ability to predict which communities will be protective. We studied how bacteria influence two major bacterial both vitro and gnotobiotic mice. Whereas single species alone had negligible effects, resistance greatly increased with community diversity. Moreover, this community-level rested critically upon certain being present. explained these ecological patterns through collective resistant consume nutrients that overlap those used pathogen. Furthermore, applied our findings successfully resist a novel target strain. Our work provides reason why diversity is beneficial suggests route for rational design pathogen-resistant communities.

Language: Английский

Citations

165
Quorum sensing for population-level control of bacteria and potential therapeutic applications DOI
Shengbo Wu, Jiaheng Liu, Chunjiang Liu

et al.

Cellular and Molecular Life Sciences, Journal Year: 2019, Volume and Issue: 77(7), P. 1319 - 1343

Published: Oct. 14, 2019

Language: Английский

Citations

157
The gut microbiota contributes to the development of Staphylococcus aureus-induced mastitis in mice DOI Open Access
Xiaoyu Hu, Jian Guo, Caijun Zhao

et al.

The ISME Journal, Journal Year: 2020, Volume and Issue: 14(7), P. 1897 - 1910

Published: April 27, 2020

Language: Английский

Citations

156
Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy DOI Creative Commons

Connor Campbell,

Mrunmayee Kandalgaonkar, Rachel M. Golonka

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(2), P. 294 - 294

Published: Jan. 20, 2023

Gut microbes and their metabolites are actively involved in the development regulation of host immunity, which can influence disease susceptibility. Herein, we review most recent research advancements gut microbiota–immune axis. We discuss detail how microbiota is a tipping point for neonatal immune as indicated by newly uncovered phenomenon, such maternal imprinting, utero intestinal metabolome, weaning reaction. describe shapes both innate adaptive immunity with emphasis on short-chain fatty acids secondary bile acids. also comprehensively delineate disruption axis results immune-mediated diseases, gastrointestinal infections, inflammatory bowel cardiometabolic disorders (e.g., cardiovascular diabetes, hypertension), autoimmunity rheumatoid arthritis), hypersensitivity asthma allergies), psychological anxiety), cancer colorectal hepatic). further encompass role fecal transplantation, probiotics, prebiotics, dietary polyphenols reshaping therapeutic potential. Continuing, examine modulates therapies, including checkpoint inhibitors, JAK anti-TNF therapies. lastly mention current challenges metagenomics, germ-free models, recapitulation to achieve fundamental understanding regulates immunity. Altogether, this proposes improving immunotherapy efficacy from perspective microbiome-targeted interventions.

Language: Английский

Citations

116
Ecological rules for the assembly of microbiome communities DOI Creative Commons
Katharine Z. Coyte, Chitong Rao, Seth Rakoff-Nahoum

et al.

PLoS Biology, Journal Year: 2021, Volume and Issue: 19(2), P. e3001116 - e3001116

Published: Feb. 19, 2021

Humans and many other hosts establish a diverse community of beneficial microbes anew each generation. The order identity incoming symbionts is critical for health, but what determines the success assembly process remains poorly understood. Here we develop ecological theory to identify factors important microbial assembly. Our method maps out all feasible pathways given microbiome—with analogies mutational underlying fitness landscapes in evolutionary biology. Building these “assembly maps” reveals tradeoff at heart process. Ecological dependencies between members microbiota make predictable—and can provide metabolic benefits host—but may also create barriers This effect occurs because interdependent species fail when relies on colonize first. We support our predictions with published data from preterm infant microbiota, where find that dependence associated predictable arrival. models suggest overcome via mechanisms either promote uptake multiple symbiont one step or feed early colonizers. predicted importance host feeding supported by impacts breast milk human microbiome. conclude both microbe interactions are trajectory microbiome

Language: Английский

Citations

111