New Perspectives on Sleep Regulation by Tea: Harmonizing Pathological Sleep and Energy Balance under Stress DOI Creative Commons
Jing Ouyang, Yuxuan Peng, Yushun Gong

et al.

Foods, Journal Year: 2022, Volume and Issue: 11(23), P. 3930 - 3930

Published: Dec. 5, 2022

Sleep, a conservative evolutionary behavior of organisms to adapt changes in the external environment, is divided into natural sleep, healthy state, and sickness which occurs stressful environments or during illness. Sickness sleep plays an important role maintaining energy homeostasis under injury promoting physical recovery. Tea, popular phytochemical-rich beverage, has multiple health benefits, including lowering stress regulating metabolism sleep. However, tea received little attention. The mechanism underlying regulation its association with maintenance injured remains be elucidated. This review examines current research on effect regulation, focusing function modulating through metabolism, damage repair model organisms. potential mechanisms are further suggested. Based biohomology this provides novel insights new perspective restoring from diseases.

Language: Английский

Functional roles of REM sleep DOI Creative Commons
Yasutaka Mukai, Akihiro Yamanaka

Neuroscience Research, Journal Year: 2022, Volume and Issue: 189, P. 44 - 53

Published: Dec. 23, 2022

Language: Английский

Citations

17
Time‐Dependent Regulation of Sleep‐Wakefulness and Electroencephalographic Characteristics by Spontaneous Running in Male Mice DOI Open Access
Weiwei Zhou,

Jialin Zhou,

Quan Lu

et al.

Journal of Sleep Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

ABSTRACT The relationship between physical activity and sleep quality is a critical area of investigation, given the importance both behaviours for health disease. Despite common use running wheels to assess circadian rhythms exercise, their impact on has not been thoroughly explored. Here, we present detailed analysis how voluntary affected sleep/wakefulness duration, architecture electrophysiological characteristics in mice. Sequential electroencephalogram (EEG) assessments revealed that elicits progressive alteration sleep/wake configurations, including reduction overall daily time an enhancement consolidation. These modifications exhibited temporal association with intensity activities. observed changes duration partially persist even after discontinuation running. Spontaneous also gradually changed amplitude and/or frequency EEG theta power only during phase but rapid eye movement (REMS). In vivo endoscopic calcium imaging freely behaving mice REMS were accompanied by activation largely shared yet distinctive neuronal cohorts within hippocampal CA1 region, concomitant oscillations behaviours. findings highlight dynamic nature regulation response exercise suggest played pivotal role modulating need balance wakefulness.

Language: Английский

Citations

0
Loss of Snord116 impacts lateral hypothalamus, sleep, and food-related behaviors DOI Creative Commons
Marta Pace, Matteo Falappa, Andrea Freschi

et al.

JCI Insight, Journal Year: 2020, Volume and Issue: 5(12)

Published: May 4, 2020

Imprinted genes are highly expressed in the hypothalamus; however, whether specific imprinted affect hypothalamic neuromodulators and their functions is unknown. It has been suggested that Prader–Willi syndrome (PWS), a neurodevelopmental disorder caused by lack of paternal expression at chromosome 15q11–q13, characterized insufficiency. Here, we investigate role paternally Snord116 gene within context sleep metabolic abnormalities PWS, report significant this function organization 2 main neuromodulatory systems lateral hypothalamus (LH) — namely, orexin (OX) melanin concentrating hormone (MCH) systems. We observed dynamics between neuronal discharge LH sleep-wake states mice with deletion (PWScrm+/p–) compromised. This abnormal state–dependent activity paralleled reduction OX neurons mutant mice. Therefore, propose an imbalance OX- MCH-expressing reflects series deficits manifested such as dysregulation rapid eye movement (REM) sleep, food intake, temperature control.

Language: Английский

Citations

24
The relationship between fasting-induced torpor, sleep, and wakefulness in laboratory mice DOI Creative Commons
Yi‐Ge Huang, Sarah Jane Flaherty, Carina A. Pothecary

et al.

SLEEP, Journal Year: 2021, Volume and Issue: 44(9)

Published: April 10, 2021

Abstract Study Objectives Torpor is a regulated and reversible state of metabolic suppression used by many mammalian species to conserve energy. Whereas the relationship between torpor sleep has been well-studied in seasonal hibernators, less known about effects fasting-induced on states vigilance brain activity laboratory mice. Methods Continuous monitoring electroencephalogram (EEG), electromyogram (EMG), surface body temperature was undertaken adult, male C57BL/6 mice over consecutive days scheduled restricted feeding. Results All animals showed bouts hypothermia that became progressively deeper longer as fasting progressed. EEG EMG were markedly affected hypothermia, although typical electrophysiological signatures non-rapid eye movement (NREM) sleep, rapid (REM) wakefulness enabled us perform vigilance-state classification all cases. Consistent with previous studies, hypothermic initiated from indistinguishable NREM power decreasing gradually parallel temperature. During deep REM largely abolished, we observed shivering-associated intense bursts muscle activity. Conclusions Our study highlights important similarities mice, daily Djungarian hamsters hibernation seasonally hibernating species. Future studies are necessary clarify subsequent sleep.

Language: Английский

Citations

23
Sex-related differences within sleep–wake dynamics, cataplexy, and EEG fast-delta power in a narcolepsy mouse model DOI Open Access

Louise Piilgaard,

Laura Rose,

C.G. Hviid

et al.

SLEEP, Journal Year: 2022, Volume and Issue: 45(7)

Published: March 10, 2022

Abstract Narcolepsy type 1 (NT1) is a sleep–wake disorder caused by selective loss of hypocretin (HCRT, also called orexin) neurons. Although the prevalence NT1 equal in men and women, sex differences symptomatology have been reported humans other species. Yet, most preclinical studies fail to include females, resulting gender bias within translational drug development. We used hcrt-tTA;TetO DTA mice (NT1 mice) that lose their HCRT neurons upon dietary doxycycline removal examine detail effect on symptoms characteristics. recorded 24-h electroencephalography (EEG), electromyography (EMG), video adult male female for behavioral state quantification. While conducting this study, we recognized another arrest different from cataplexy: shorter lasting with high δ power. termed these delta attacks propose set criteria quantifying future research. Our findings show both sexes exhibit instability, which was markedly higher females more arrests interrupting wake episodes. Females exhibited increased at expense sleep during dark phase, decreased rapid eye movement (REM) day. During fast-δ (2.5–4 Hz) non-rapid (NREM) θ (6–10 EEG spectral power REM were lower compared males. demonstrate biologically driven sex-related exist calls including

Language: Английский

Citations

15
The melanin-concentrating hormone system as a target for the treatment of sleep disorders DOI Creative Commons

Liam E. Potter,

Christian R. Burgess

Frontiers in Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Sept. 13, 2022

Given the widespread prevalence of sleep disorders and their impacts on health, it is critical that researchers continue to identify evaluate novel avenues treatment. Recently melanin-concentrating hormone (MCH) system has attracted commercial scientific interest as a potential target pharmacotherapy for disorders. This emerges from basic research demonstrating role MCH in regulating sleep, particularly REM sleep. In addition this regulation, receptor 1 (MCHR1) have been implicated wide variety other physiological functions behaviors, including feeding/metabolism, reward, anxiety, depression, learning. The literature system, history drug development, provide cause both skepticism cautious optimism about prospects MCH-targeting drugs Extensive efforts focused developing MCHR1 antagonists use obesity, however, few these advanced clinical trials, none gained regulatory approval. Additional will be needed fully characterize system’s example, differentiate between MCH-neuron peptide/receptor-mediated functions. Additionally, number issues relating design pose practical challenge pharmacotherapies targeting system.

Language: Английский

Citations

14
Sleep-Wake Control by Melanin-Concentrating Hormone (MCH) Neurons: a Review of Recent Findings DOI
Sathyajit S. Bandaru, Mudasir A. Khanday,

Nazifa Ibrahim

et al.

Current Neurology and Neuroscience Reports, Journal Year: 2020, Volume and Issue: 20(12)

Published: Oct. 2, 2020

Language: Английский

Citations

20
Sleep-mediated regulation of reward circuits: implications in substance use disorders DOI Open Access
Rong Guo, Dylan T. Vaughan, Ana L. Almeida Rojo

et al.

Neuropsychopharmacology, Journal Year: 2022, Volume and Issue: 48(1), P. 61 - 78

Published: June 16, 2022

Language: Английский

Citations

12
An Electroencephalogram Signature of Melanin-Concentrating Hormone Neuron Activities Predicts Cocaine Seeking DOI Creative Commons
Yao Wang,

Danyang Li,

Joseph Widjaja

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(9), P. 739 - 751

Published: April 26, 2024

Identifying biomarkers that predict substance use disorder propensity may better strategize antiaddiction treatment. Melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus critically mediate interactions between sleep and use; however, their activities are largely obscured surface electroencephalogram (EEG) measures, hindering development of biomarkers.

Language: Английский

Citations

2
Comparative Perspectives that Challenge Brain Warming as the Primary Function of REM Sleep DOI Creative Commons
Gianina Ungurean, Baptiste Barrillot,

Dolores Martı́nez-González

et al.

iScience, Journal Year: 2020, Volume and Issue: 23(11), P. 101696 - 101696

Published: Oct. 17, 2020

Rapid eye movement (REM) sleep is a paradoxical state of wake-like brain activity occurring after non-REM (NREM) in mammals and birds. In mammals, cooling during NREM followed by warming REM sleep, potentially preparing the to perform adaptively upon awakening. If primary function then it should occur other animals with similar states. We measured cortical temperature pigeons bearded dragons, lizards that exhibit NREM-like REM-like resembling wakefulness. pigeons, decreased increased sleep. However, did not increase when dragons switched from Our findings indicate universal outcome states characterized activity, challenging hypothesis their warm preparation for

Language: Английский

Citations

18