Tau and β-Amyloid Burden Predict Actigraphy-Measured and Self-Reported Impairment and Misperception of Human Sleep DOI Open Access
Joseph R. Winer, Allison Morehouse, Laura Fenton

et al.

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(36), P. 7687 - 7696

Published: July 21, 2021

Alzheimer9s disease is associated with poor sleep, but the impact of tau and β-amyloid (Aβ) pathology on sleep remains largely unknown. Here, we test hypothesis that Aβ predict unique impairments in objective self-perceived human under real-life, free-living conditions. Eighty-nine male female cognitively healthy older adults received 18F-FTP-tau 11C-PIB-Aβ PET imaging, 7 nights actigraphy questionnaire measures, neurocognitive assessment. Tau burden, not Aβ, was markedly worse sleep. In contrast, were self-reported quality. Of clinical relevance, burden predicted a perceptual mismatch between subject evaluation, individuals underestimating their The magnitude this further by executive function. Thus, early-stage deposition are linked distinct phenotypes real-world impairment, one includes cognitive misperception own health. SIGNIFICANCE STATEMENT disruption, often before significant memory decline. real-life patterns behavior have potential to serve as window into early progression. 89 adults, found wristwatch actigraphy-measured quality, both independently predictive Furthermore, greater more likely underestimate quality underestimation These data support role impairment key marker disease, offer possibility may be an affordable scalable tool quantifying disease-related behavioral changes.

Language: Английский

Rapid Eye Movement Sleep, Neurodegeneration, and Amyloid Deposition in Aging DOI
Claire André, Pierre Champetier,

Stéphane Rehel

et al.

Annals of Neurology, Journal Year: 2023, Volume and Issue: 93(5), P. 979 - 990

Published: Jan. 15, 2023

Rapid eye movement (REM) sleep is markedly altered in Alzheimer's disease (AD), and its reduction older populations associated with AD risk. However, little known about the underlying brain mechanisms. Our objective was to investigate relationships between REM integrity amyloid deposition, gray matter volume, perfusion aging.We included 121 cognitively unimpaired adults (76 women, mean age 68.96 ± 3.82 years), who underwent a polysomnography, T1-weighted magnetic resonance imaging, early late Florbetapir positron emission tomography scans evaluate perfusion, deposition. We computed indices reflecting macro- microstructural (ie, normalized electroencephalographic spectral power values). Voxel-wise multiple regression analyses were conducted neuroimaging data, controlling for age, sex, education, apnea-hypopnea index, apolipoprotein E ε4 status.Lower frontal, anterior posterior cingulate, precuneus areas decreased delta slowing (slow/fast frequencies ratio), increased alpha beta power. To lower extent, similar results obtained volume delta, alpha, In addition, theta more marginally greater diffuse deposition fronto-temporal parieto-occipital areas.These suggest that alterations of microstructure are neurodegeneration neocortical adults. Further studies warranted replicate these findings, determine whether exhibiting at risk cognitive decline belonging continuum. ANN NEUROL 2023;93:979-990.

Language: Английский

Citations

19
Somatostatin and the pathophysiology of Alzheimer’s disease DOI
Victor N. Almeida

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 96, P. 102270 - 102270

Published: March 13, 2024

Language: Английский

Citations

7
Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer’s disease DOI Creative Commons
Astrid Devulder, Greet Vanderlinden,

Leen Van Langenhoven

et al.

Brain, Journal Year: 2024, Volume and Issue: 148(2), P. 506 - 520

Published: July 10, 2024

Both sleep alterations and epileptiform activity are associated with the accumulation of amyloid-β tau pathology currently investigated for potential therapeutic interventions in Alzheimer's disease. However, a bidirectional intertwining relationship between neuronal hyperexcitability might modulate effects disease on corresponding associations. To investigate this, we performed multiple day simultaneous foramen ovale (FO) plus scalp EEG polysomnography recordings acquired 18F-MK6240 PET-MR three patients prodromal stage two mild moderate dementia due to disease, respectively. As an eligibility criterion present study, subjects either had history recent seizure (n = 2) or subclinical (SEA) previous taken research context 3). The standard uptake value ratio (SUVR) asymmetry index (AI) were calculated priori-defined volumes interest. Linear mixed-effects models used study associations interictal discharges (IEDs), parameters SUVR. Epileptiform was bilateral but asymmetrically FO electrodes all ≥95% IEDs not visible EEG. In one patient, focal seizures detected electrodes, both without visual correlate. We observed lateralized periodic discharges, brief potentially ictal rhythmic delta four patients. Unlike EEG, intracranial showed lateralization activity. Although amount SUVR binding different interest, there congruent towards most epileptic hemisphere mesial (P 0.007) lateral temporal cortex 0.006). abundant during slow wave (SWS) (92/h) non-REM 2 (N2, 81/h), followed by 1 (N1, 33/h) least frequent wakefulness (17/h) REM (9/h). extent reflected relative time each spent [REM% 0.415), N1% 0.668), N2% 0.442), SWS% 0.988)], arousal 0.317), apnoea-hypopnoea 0.846) oxygen desaturation 0.746). Together, our observations suggest multi-directional interaction sleep,

Language: Английский

Citations

6
Waste clearance shapes aging brain health DOI Creative Commons
Li-Feng Jiang-Xie, Antoine Drieu, Jonathan Kipnis

et al.

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

SummaryBrain health is intimately connected to fluid flow dynamics that cleanse the brain of potentially harmful waste material. This system regulated by vascular dynamics, maintenance perivascular spaces, neural activity during sleep, and lymphatic drainage in meningeal layers. However, aging can impinge on each these layers regulation, leading impaired cleansing emergence various age-associated neurological disorders, including Alzheimer's Parkinson's diseases. Understanding intricacies regulation how this becomes altered with age could reveal new targets therapeutic strategies tackle decline.

Language: Английский

Citations

6
Tau and β-Amyloid Burden Predict Actigraphy-Measured and Self-Reported Impairment and Misperception of Human Sleep DOI Open Access
Joseph R. Winer, Allison Morehouse, Laura Fenton

et al.

Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 41(36), P. 7687 - 7696

Published: July 21, 2021

Alzheimer9s disease is associated with poor sleep, but the impact of tau and β-amyloid (Aβ) pathology on sleep remains largely unknown. Here, we test hypothesis that Aβ predict unique impairments in objective self-perceived human under real-life, free-living conditions. Eighty-nine male female cognitively healthy older adults received 18F-FTP-tau 11C-PIB-Aβ PET imaging, 7 nights actigraphy questionnaire measures, neurocognitive assessment. Tau burden, not Aβ, was markedly worse sleep. In contrast, were self-reported quality. Of clinical relevance, burden predicted a perceptual mismatch between subject evaluation, individuals underestimating their The magnitude this further by executive function. Thus, early-stage deposition are linked distinct phenotypes real-world impairment, one includes cognitive misperception own health. SIGNIFICANCE STATEMENT disruption, often before significant memory decline. real-life patterns behavior have potential to serve as window into early progression. 89 adults, found wristwatch actigraphy-measured quality, both independently predictive Furthermore, greater more likely underestimate quality underestimation These data support role impairment key marker disease, offer possibility may be an affordable scalable tool quantifying disease-related behavioral changes.

Language: Английский

Citations

35