Contributions and synaptic basis of diverse cortical neuron responses to task performance DOI Creative Commons
Robert C. Froemke, Michele N. Insanally, Badr F. Albanna

et al.

Research Square (Research Square), Journal Year: 2022, Volume and Issue: unknown

Published: May 18, 2022

Abstract Neuronal responses during behavior are diverse, ranging from highly reliable ‘classical’ to irregular or seemingly-random ‘non-classically responsive’ firing. While a continuum of response properties is frequently observed across neural systems, little known about the synaptic origins and contributions diverse profiles network function, perception, behavior. Here we use task-performing, spiking recurrent model incorporating spike-timing-dependent plasticity that captures heterogeneous measured auditory cortex behaving rodents. Classically responsive non-classically units contributed task performance via output connections, respectively. Excitatory inhibitory independently shaped performance. Local patterns inputs predicted as well cortical neurons in vivo whole-cell recordings Thus diversity emerges rules with distinctly important functions for

Language: Английский

Hippocampal CA1 Neurons Represent Positive Feedback During the Learning Process of an Associative Memory Task DOI Creative Commons
Shogo Takamiya, Kazuki Shiotani, Tomoya Ohnuki

et al.

Frontiers in Systems Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: Sept. 6, 2021

The hippocampus is crucial for forming associations between environmental stimuli. However, it unclear how neural activities of hippocampal neurons dynamically change during the learning process. To address this question, we developed an associative memory task rats with auditory In task, were required to associate tone pitches (high and low) ports (right left) obtain a reward. We recorded firing activity in CA1 process task. As result, many increased their rates when received reward after choosing either left or right port. referred these cells as “reward-direction cells.” Furthermore, proportion reward-direction middle-stage but decreased completion learning. This result suggests that might serve “positive feedback” signal facilitates formation port choice.

Language: Английский

Citations

40
Contributions of cortical neuron firing patterns, synaptic connectivity, and plasticity to task performance DOI Creative Commons
Michele N. Insanally, Badr F. Albanna,

Jade Toth

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 17, 2024

Abstract Neuronal responses during behavior are diverse, ranging from highly reliable ‘classical’ to irregular ‘non-classically responsive’ firing. While a continuum of response properties is observed across neural systems, little known about the synaptic origins and contributions diverse network function, perception, behavior. To capture heterogeneous measured auditory cortex rodents performing frequency recognition task, we use novel task-performing spiking recurrent incorporating spike-timing-dependent plasticity. Reliable units contribute differentially task performance via output connections, respectively. Excitatory plasticity shifts distribution while inhibition constrains its diversity. Together both improve with full engagement. The same local patterns inputs predict cortical neurons in vivo whole-cell recordings Thus, function emerge rules.

Language: Английский

Citations

6
Learning enhances encoding of time and temporal surprise in mouse primary sensory cortex DOI Creative Commons
Rebecca J. Rabinovich,

Daniel D. Kato,

Randy M. Bruno

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Sept. 20, 2022

Abstract Primary sensory cortex has long been believed to play a straightforward role in the initial processing of information. Yet, superficial layers overall are sparsely active, even during stimulation; additionally, cortical activity is influenced by other modalities, task context, reward, and behavioral state. Our study demonstrates that reinforcement learning dramatically alters representations among longitudinally imaged neurons mouse primary somatosensory cortex. Learning an object detection recruits previously unresponsive neurons, enlarging neuronal population sensitive touch choice. Cortical responses decrease upon repeated stimulus presentation outside task. Moreover, training improves encoding passage time, unexpected deviations trial timing elicit stronger than touches do. In conclusion, exhibit high degree learning-dependent plasticity strongly modulated non-sensory but behaviorally-relevant features, such as surprise.

Language: Английский

Citations

21
A latent pool of neurons silenced by sensory-evoked inhibition can be recruited to enhance perception DOI Creative Commons
Oliver Gauld, Adam M. Packer, Lloyd Russell

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(14), P. 2386 - 2403.e6

Published: May 9, 2024

To investigate which activity patterns in sensory cortex are relevant for perceptual decision-making, we combined two-photon calcium imaging and targeted optogenetics to interrogate barrel during discrimination. We trained mice discriminate bilateral whisker deflections report decisions by licking left or right. Two-photon revealed sparse coding of contralateral ipsilateral input layer 2/3, with most neurons remaining silent the task. Activating pyramidal using holographic photostimulation evoked a bias that scaled number photostimulated. This effect was dominated optogenetic activation non-coding neurons, did not show motor-related task performance. Photostimulation also potent recruitment cortical inhibition processing, strongly preferentially suppressed neurons. Our results suggest pool selectively network can be recruited enhance perception.

Language: Английский

Citations

4
Formation of brain-wide neural geometry during visual item recognition in monkeys DOI Creative Commons
He Chen, Jun Kunimatsu, Tomomichi Oya

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(3), P. 111936 - 111936

Published: Jan. 31, 2025

Neural dynamics are thought to reflect computations that relay and transform information in the brain. Previous studies have identified neural population many individual brain regions as a trajectory geometry, preserving common computational motif. However, whether these populations share particular geometric patterns across brain-wide remains unclear. Here, by mapping widely temporal/frontal/limbic cortical subcortical structures of monkeys, we show 10 populations, including 2,500 neurons, propagate visual item stochastic manner. We found inputs predominantly evoked rotational higher-order area, TE, its downstream striatum tail, while curvy/straight appeared frequently orbitofrontal/hippocampal network. These changes were not deterministic but rather according their respective emergence rates. Our meta-analysis results indicate propagates heterogeneous mixture signals

Language: Английский

Citations

0
A neural circuit targeting technique for investigating functional input-output organization in the nervous system DOI Creative Commons
Yusuke Kasuga,

Xiao-Wei Gu,

Tomoya Ohnuki

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

Abstract Neurons communicate information across circuits and the function of cells in these is determined by both afferent inputs they receive efferent outputs send to other brain regions 1,2 . To study activity specific neuronal populations, transneuronal anterograde 3 retrograde 4–6 viral approaches have been employed define neural circuit elements or outputs, respectively. However, what missing a way neurons based on their outputs. Applying combination multiple recombinases anterograde/retrograde viruses, we developed technique called input-output P rojection-based IN tersectional C ircuit-tagging E nabled R ecombinases (PINCER) target cell types investigate functional organization circuits. We show logic application this with vivo calcium imaging optogenetic reveal distinct functions dynamics connectivity defined populations amygdala for emotional processing. Specifically, PINCER allowed parsing valence salience an type selectively mediating aversive memory formation. This allows neuroscientists identify novel subclasses combinatorial anatomical connectivity, providing tool fine dissection properties

Language: Английский

Citations

0
Population coding under the scale-invariance of high-dimensional noise DOI Creative Commons
S. Amin Moosavi, Sai Sumedh R. Hindupur, Hideaki Shimazaki

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 26, 2024

Abstract High-dimensional neural activities exhibiting scale-invariant, power-law noise spectra are ubiquitously observed across various brain regions and species. However, their impact on information coding remains unclear. We provide the scaling conditions for covariance that clarify boundedness of establish a quantitative relation between capacity population size, based properties scale-invariant in stimulus-evoked mouse V1 neurons. Our analysis reveals sublinearly small components align sufficiently with signal direction, enabling neurons to convey stimulus unboundedly as size increases. These findings demonstrate quasi-universal lays foundation understanding codes, highlighting critical need consider full spectrum high-dimensional noise.

Language: Английский

Citations

3
Stability of cross-sensory input to primary somatosensory cortex across experience DOI Creative Commons

Daniel D. Kato,

Randy M. Bruno

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

3
Localized and global representation of prior value, sensory evidence, and choice in male mouse cerebral cortex DOI Creative Commons
Kotaro Ishizu, S. Nishimoto, Yutaro Ueoka

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: May 22, 2024

Abstract Adaptive behavior requires integrating prior knowledge of action outcomes and sensory evidence for making decisions while maintaining future actions. As outcome- sensory-based are often tested separately, it is unclear how these processes integrated in the brain. In a tone frequency discrimination task with two sound durations asymmetric reward blocks, we found that neurons medial prefrontal cortex male mice represented additive combination expectations choices. The inputs choices were selectively decoded from auditory irrespective priors secondary motor cortex, respectively, suggesting localized computations variables required within single trials. contrast, all recorded regions values needed to be maintained across We propose global different time scales cerebral cortex.

Language: Английский

Citations

2
An intra-oral flavor detection task in freely moving mice DOI Creative Commons
Kazuki Shiotani, Yuta Tanisumi, Yuma Osako

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(2), P. 108924 - 108924

Published: Jan. 16, 2024

Flavor plays a critical role in the pleasure of food. research has mainly focused on human subjects and revealed that many brain regions are involved flavor perception. However, animal models for elucidating mechanisms neural circuits lacking. Herein, we demonstrate use novel behavioral task which mice capable detection. When olfactory pathways were blocked, they could not perform task. accuracy was affected when gustatory pathway blocked by benzocaine. These results indicate performed this detection based olfaction. We conclude can contribute to

Language: Английский

Citations

1