Top-down prediction signals from the medial prefrontal cortex govern auditory cortex prediction errors

Cell Reports, Journal Year: 2025, Volume and Issue: 44(4), P. 115538 - 115538

Published: April 1, 2025

Under the predictive coding framework, brain generates a model of environment based on previous experiences. Incoming sensory information is compared to this model, such that if predictions do not match inputs, prediction error generated. Predictions are passed top-down, and errors emerge when bottom-up does predictions. Prediction occur sequentially in primary auditory cortex (A1) then medial prefrontal (mPFC). Here, we test hypothesis mPFC sends contribute generation errors. We used optogenetics block top-down signals from while recording neuronal A1 under classical "oddball" paradigm. Blocking reduces response rare sounds, it affect responses predictable or random sounds. Our results provide empirical evidence for enhance unpredicted stimuli.

Language: Английский

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Parallel mechanisms signal a hierarchy of sequence structure violations in the auditory cortex

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Nov. 7, 2024

The brain predicts regularities in sensory inputs at multiple complexity levels, with neuronal mechanisms that remain elusive. Here, we monitored auditory cortex activity during the local-global paradigm, a protocol nesting different regularity levels sound sequences. We observed mice encode local predictions based on stimulus occurrence and transition probabilities, because responses are boosted upon prediction violation. This boosting was due to both short-term adaptation an adaptation-independent surprise mechanism resisting anesthesia. In parallel, only wakefulness, VIP interneurons responded omission of locally expected repeat sequence ending, thus providing chunking signal potentially useful for establishing global structure. When this structure violated, by either shortening or ending it but globally unexpected transition, slightly increased PV neurons, respectively. Hence, distinct cellular predict

Language: Английский

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Stimulus-specific prediction error neurons in mouse auditory cortex

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Jan. 7, 2023

Comparing expectation with experience is an important neural computation performed throughout the brain and a hallmark of predictive processing. Experiments that alter sensory outcome animal's behavior reveal enhanced responses to unexpected self-generated stimuli, indicating populations neurons in cortex may reflect prediction errors - mismatches between experience. However, stimuli could also arise through non-predictive mechanisms, such as movement-based facilitation neuron's inherent sound responses. If error exist cortex, it unknown whether they manifest general responses, or respond specificity distinct stimulus dimensions. To answer these questions, we trained mice expect simple sound-generating recorded auditory activity heard either expected sounds deviated from one multiple Our data learns suppress along acoustic dimensions simultaneously. We identify population are not responsive passive but explicitly encode errors. These abundant only animals learned motor-sensory expectation, two specific violations rather than generic signal.

Language: Английский

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Multimodal mismatch responses in mouse auditory cortex

Published: March 22, 2024

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory (ACx), we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor mismatches, they closely resemble visuomotor mismatch (V1). Finally, testing for cross modal coupling sound amplitude flow speed running, were amplified when paired with concurrent mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3.

Language: Английский

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MULTIMODAL MISMATCH RESPONSES IN MOUSE AUDITORY CORTEX

Published: Nov. 18, 2024

Our movements result in predictable sensory feedback that is often multimodal. Based on deviations between predictions and actual input, primary areas of cortex have been shown to compute sensorimotor prediction errors. How errors one modality influence the computation another still unclear. To investigate multimodal mouse auditory (ACx), we used a virtual environment experimentally couple running both self-generated visual feedback. Using two-photon microscopy, first characterized responses layer 2/3 (L2/3) neurons sounds, stimuli, onsets found all three stimuli. Probing evoked by audiomotor mismatches, they closely resemble visuomotor mismatch (V1). Finally, testing for cross modal coupling sound amplitude flow speed running, were amplified when paired with concurrent mismatches. results demonstrate non-hierarchical interactions shape error cortical L2/3. *** Dear reader, please note this manuscript formatted standard submission format, statistical information provided Table S1.

Language: Английский

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