Current Biology, Journal Year: 2023, Volume and Issue: 33(8), P. R298 - R300
Published: April 1, 2023
Language: Английский
Science, Journal Year: 2025, Volume and Issue: 388(6742), P. 109 - 115
Published: April 4, 2025
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely bacteria, and only once archaea. We show that uniaxial compression induces haloarchaea, forming tissue-like structures. These archaeal tissues are mechanically molecularly distinct from their unicellular lifestyle, mimicking several eukaryotic features. Archaeal undergo multinucleate stage followed by tubulin-independent cellularization, orchestrated active membrane tension at cell size. After tissue junction elasticity becomes akin to animal tissues, giving rise two types—peripheral (Per) central scutoid (Scu) cells—with actin protein glycosylation polarity patterns. Our findings highlight the potential convergent evolution biophysical mechanism emergence multicellular systems across domains life.
Language: Английский
Citations
3
Nature, Journal Year: 2024, Volume and Issue: 630(8015), P. 116 - 122
Published: May 22, 2024
Eukaryotes have evolved towards one of two extremes along a spectrum strategies for remodelling the nuclear envelope during cell division: disassembling in an open mitosis or constructing intranuclear spindle closed
Language: Английский
Citations
16
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 25, 2024
Abstract All animals develop from a single-celled zygote into complex multicellular organism through series of precisely orchestrated processes. Despite the remarkable conservation early embryogenesis across animals, evolutionary origins this process remain elusive. By combining time-resolved imaging and transcriptomic profiling, we show that single cells ichthyosporean Chromosphaera perkinsii - close relative diverged approximately 1 billion years ago undergo symmetry breaking cleavage divisions to produce prolonged colony with distinct co-existing cell types. Our findings about autonomous developmental program C. , hint such animal-like development is either much older than previously thought or evolved convergently in ichthyosporeans. One-Sentence Summary The develops via breaking, divisions, forms spatially-organized colonies
Language: Английский
Citations
7
Nature, Journal Year: 2024, Volume and Issue: 635(8038), P. 382 - 389
Published: Nov. 6, 2024
All animals develop from a single-celled zygote into complex multicellular organism through series of precisely orchestrated processes1,2. Despite the remarkable conservation early embryogenesis across animals, evolutionary origins how and when this process first emerged remain elusive. Here, by combining time-resolved imaging transcriptomic profiling, we show that single cells ichthyosporean Chromosphaera perkinsii—a close relative diverged about 1 billion years ago3,4—undergo symmetry breaking cleavage divisions to produce prolonged colony with distinct co-existing cell types. Our findings autonomous palintomic developmental program C. perkinsii hint such development either is much older than previously thought or evolved convergently in ichthyosporeans. The develops via divisions, it forms spatially organized colonies
Language: Английский
Citations
4
Current Opinion in Genetics & Development, Journal Year: 2023, Volume and Issue: 81, P. 102062 - 102062
Published: June 18, 2023
A major hurdle in an embryo's life is the initiation of its own transcriptional program, a process termed Zygotic Genome Activation (ZGA). In many species, ZGA intricately timed, with bulk transcription initiating at end series reductive cell divisions when cycle duration increases. At same time, changes genome architecture give rise to chromatin states that are permissive RNA polymerase II activity. Yet, we still do not understand events trigger gene expression right time and correct sequence. Here discuss new discoveries deepen our understanding how zygotic genes primed for transcription, these regulated by nuclear import. Finally, speculate on evolutionary basis timing as exciting future direction field.
Language: Английский
Citations
9
Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)
Published: July 29, 2024
Ichthyosporea is an underexplored group of unicellular eukaryotes closely related to animals. Thanks their phylogenetic position, genomic content, and development through a multinucleate coenocyte reminiscent some animal embryos, the members are being increasingly recognized as pivotal study origins. We delve into existing knowledge Ichthyosporea, identify gaps discuss life cycles, insights, development, potential be model organisms. also underestimated diversity ichthyosporeans, based on new environmental data analyses. This review will essential resource for researchers venturing ichthyosporeans. crucial understanding origins evolution. Review outlines history recent advancements in ichthyosporean biology, genomics, genetics, provides insight diversity.
Language: Английский
Citations
2
Current Opinion in Biomedical Engineering, Journal Year: 2024, Volume and Issue: 30, P. 100521 - 100521
Published: Jan. 26, 2024
Language: Английский
Citations
1
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: March 15, 2024
A conserved process of early embryonic development in metazoans is the reductive cell divisions following oocyte fertilization, termed cleavages. Cell cleavage cycles usually start synchronously, lengthen differentially between cells becoming asynchronous, and cease before major morphogenetic events, such as germ layer formation gastrulation. Despite exhibiting species-specific characteristics, regulation dynamics comes down to common controllers acting mostly at single cell/nucleus level, nucleus-to-cytoplasmic ratio zygotic genome activation. Remarkably, recent work has linked emergence collective behavior during embryogenesis, including pattern changes embryo-scale mechanics, raising question how single-cell coordinate processes. In this review, we summarize studies across species where an association cleavages was made, discuss underlying mechanisms, propose that cell-to-cell variability can serve a mechanism long-range coordination developing embryos.
Language: Английский
Citations
1
eLife, Journal Year: 2024, Volume and Issue: 12
Published: March 22, 2024
The genomes of close unicellular relatives animals encode orthologs many genes that regulate animal development. However, little is known about the function such in organisms or evolutionary process by which these came to multicellular Hippo pathway, regulates cell proliferation and tissue size animals, present some closest including amoeboid organism Capsaspora owczarzaki . We previously showed ortholog pathway nuclear effector Yorkie/YAP/TAZ (coYki) actin dynamics three-dimensional morphology aggregates, but dispensable for control (Phillips et al., 2022). upstream components, whether how they coYki , remained unknown. Here, we analyze kinases coHpo coWts generating mutant lines each gene. Loss either kinase results increased localization coYki, indicating an ancient, premetazoan origin this regulatory mechanism. Strikingly, find loss causes a contractile behavior density packing within aggregates. further show not due differences proliferation, rather actomyosin-dependent changes architecture Given its well-established role density-regulated mutants suggests shared possibly ancient conserved control. Together, implicate cytoskeletal regulation as ancestral cascade uncover novel signaling regulating proliferation-independent manner.
Language: Английский
Citations
1
eLife, Journal Year: 2023, Volume and Issue: 12
Published: Sept. 5, 2023
The genomes of close unicellular relatives animals encode orthologs many genes that regulate animal development. However, little is known about the function such in organisms or evolutionary process by which these came to multicellular Hippo pathway, regulates cell proliferation and tissue size animals, present some closest including amoeboid organism Capsaspora owczarzaki . We previously showed ortholog pathway nuclear effector Yorkie/YAP/TAZ (coYki) actin dynamics three-dimensional morphology aggregates, but dispensable for control (Phillips et al., 2022). upstream components, whether how they coYki , remained unknown. Here, we analyze kinases coHpo coWts generating mutant lines each gene. Loss either kinase results increased localization coYki, indicating an ancient, premetazoan origin this regulatory mechanism. Strikingly, find loss causes a contractile behavior density packing within aggregates. further show not due differences proliferation, rather actomyosin-dependent changes architecture Given its well-established role density-regulated mutants suggests shared possibly ancient conserved control. Together, implicate cytoskeletal regulation as ancestral cascade uncover novel signaling regulating proliferation-independent manner.
Language: Английский
Citations
3