Association between retinal nerve fiber layer thickness and psychiatric disorders: a Mendelian randomization study DOI Creative Commons

Fuyi Qin,

Xiang Cao,

Xinling Zhao

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 27, 2023

Abstract Background: Retinal nerve fiber layer thickness, as a new visual indicator that may help diagnose mental disorders, is gaining attention from researchers. However, the causal relationship between retinal thickness and disorders still to be effectively proved. Methods: A bidirectional Two-sample Mendelian randomization analysis was utilized analyse aggregated data large-scale genome-wide association studies, we selected genetic loci for in independent abnormalities three prevalent psychiatric (schizophrenia, depression, bipolar disorder) instrumental variables. The mainly performed by inverse variance weighting weighted median method. Cochran Q test leave-one-out sensitivity were used ensure robustness of results. random polymorphism residuals outliers detect single nucleotide outliers, MR-Egger intercept horizontal pleiotropy. Results: IVW showed positively associated with schizophrenia (OR=1.057, 95%CI: 1.000-1.117, P<0.05), study disorder, MR also suggested positive disorder (OR=1.025, 1.005-1.046, which indicated possible relationships these two diseases. Depression (OR=1.000143, 0.9992631-1.001024, P=0.74) no significant association. No reverse effects on found. Conclusions: statistically has been supported means, indicating can potentially effective prediction diagnosis

Language: Английский

Molecular mechanism establishing the OFF pathway in vision DOI Creative Commons
Florentina Soto, Chin-I Lin,

Andrew Jo

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 18, 2025

Abstract Parallel ON and OFF (positive- negative-contrast) pathways fundamental to vision arise at the complex synapse of cone photoreceptors. Cone pedicles form spatially segregated functionally opposite connections with bipolar cells. Here, we discover that mammalian cones express LRFN2, a cell-adhesion molecule, which localizes pedicle base. LRFN2 stabilizes basal contacts between cell dendrites guide pathway-specific partner choices, encompassing multiple types. In addition, trans-synaptically organizes glutamate receptor clusters, determining contrast preferences pathway. converge in inner retina regulate outputs. We analyze LRFN2’s contributions ON-OFF interactions, pathway asymmetries, neural behavioral responses approaching predators. Our results reveal controls formation vision, supports parallel processing single synapse, shapes coding detection visual threats.

Language: Английский

Citations

0
Interocular distribution differences of parafoveal cone photoreceptors between dominant and non-dominant eyes assessed using an adaptive optics scanning laser ophthalmoscope DOI

Ying Chen,

Huiling Ma,

Huiyan Li

et al.

Graefe s Archive for Clinical and Experimental Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: May 10, 2025

Language: Английский

Citations

0
Transcriptome Study of rd1Mouse Brain and Association with Parkinson’s Disease DOI Creative Commons
Ying Zhou,

Yuwei Yang,

Ting Qi

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(24), P. 25756 - 25765

Published: June 6, 2024

Degeneration of the retina is intrinsically associated with pathogenesis and progression neurodegenerative diseases. However, cellular molecular mechanisms underlying association between neurodegeneration retinal degeneration are still under exploration due to complexity connectivity network nervous system. In this study, RNA-seq data from brains model retinitis pigmentosa (RP) mice previously studied Parkinson's disease (PD) were analyzed explore commonalities degenerative Differentially expressed genes in RP compared disease-related intersecting identified, including Cnr1 Septin14. These verified by quantitative real-time reverse transcription PCR Western blotting experiments. The key proteins CNR1 SEPTIN14 found be potential cotherapeutic targets for disease. conclusion, understanding diseases processes brain will not only facilitate interpretation pathomechanisms but also contribute early diagnosis development new therapeutic strategies.

Language: Английский

Citations

0
Association between retinal nerve fiber layer thickness and psychiatric disorders: a mendelian randomization study DOI Creative Commons

Qin Fuyi,

Cao Xiang,

Zhao Xinling

et al.

BMC Psychiatry, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 30, 2024

Language: Английский

Citations

0
Wide-angle simulated artificial vision enhances spatial navigation and object interaction in a naturalistic environment DOI
Sandrine Hinrichs,

Louise Placidet,

Antonin Duret

et al.

Journal of Neural Engineering, Journal Year: 2024, Volume and Issue: 21(6), P. 066005 - 066005

Published: Oct. 25, 2024

. Vision restoration approaches, such as prosthetics and optogenetics, provide visual perception to blind individuals in clinical settings. Yet their effectiveness daily life remains a challenge. Stereotyped quantitative tests used trials often fail translate into practical, everyday applications. On the one hand, assessing real-life benefits during is complicated by environmental complexity, reproducibility issues, safety concerns. other predicting behavioral of restorative therapies naturalistic environments may be crucial step before starting minimize patient discomfort unmet expectations.

Language: Английский

Citations

0
Association between retinal nerve fiber layer thickness and psychiatric disorders: a Mendelian randomization study DOI Creative Commons

Fuyi Qin,

Xiang Cao,

Xinling Zhao

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 27, 2023

Abstract Background: Retinal nerve fiber layer thickness, as a new visual indicator that may help diagnose mental disorders, is gaining attention from researchers. However, the causal relationship between retinal thickness and disorders still to be effectively proved. Methods: A bidirectional Two-sample Mendelian randomization analysis was utilized analyse aggregated data large-scale genome-wide association studies, we selected genetic loci for in independent abnormalities three prevalent psychiatric (schizophrenia, depression, bipolar disorder) instrumental variables. The mainly performed by inverse variance weighting weighted median method. Cochran Q test leave-one-out sensitivity were used ensure robustness of results. random polymorphism residuals outliers detect single nucleotide outliers, MR-Egger intercept horizontal pleiotropy. Results: IVW showed positively associated with schizophrenia (OR=1.057, 95%CI: 1.000-1.117, P<0.05), study disorder, MR also suggested positive disorder (OR=1.025, 1.005-1.046, which indicated possible relationships these two diseases. Depression (OR=1.000143, 0.9992631-1.001024, P=0.74) no significant association. No reverse effects on found. Conclusions: statistically has been supported means, indicating can potentially effective prediction diagnosis

Language: Английский

Citations

0