Royal Society of Chemistry eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 133 - 155
Published: Dec. 6, 2024
This
chapter
provides
an
overview
of
the
current
understanding
aromatherapy,
its
application
to
neurodegenerative
diseases
and
schizophrenia,
observed
effects.
It
further
explores
relationship
between
aromatherapy
neurobiology,
including
structural
features
olfactory
receptors,
signal
transmission,
distribution
in
brain.
The
transitions
into
neuroanatomy,
functioning
human
brain,
connection
limbic
system
olfactometry,
assessment
functions
schizophrenia.
Olfactory
schizophrenia
are
discussed,
comparing
brain
rodent
brains,
describing
challenges
research.
Areas
that
not
yet
fully
understood
but
presumed
be
involved
also
examined,
along
with
methods
utilized
for
research
(EEG,
PET,
fMRI),
genetic
engineering,
swabs,
psychometric
questionnaires.
STAR Protocols,
Journal Year:
2024,
Volume and Issue:
5(3), P. 103164 - 103164
Published: July 4, 2024
Optogenetic
manipulation
has
proven
a
powerful
tool
for
investigating
the
mechanisms
underlying
function
of
neuronal
networks,
but
implementing
technique
on
mammals
during
early
development
remains
challenging.
Here,
we
present
comprehensive
workflow
to
specifically
manipulate
mitral/tufted
cells
(M/TCs),
output
neurons
in
olfactory
circuit,
mediated
by
adeno-associated
virus
(AAV)
transduction
and
light
stimulation
neonatal
mice
monitor
network
activity
with
vivo
electrophysiology.
This
method
represents
an
efficient
approach
elucidate
functional
brain
development.
For
complete
details
use
execution
this
protocol,
please
refer
Chen
et
al.
Ibrain,
Journal Year:
2023,
Volume and Issue:
10(1), P. 69 - 82
Published: Dec. 21, 2023
Abstract
Numerous
brain
diseases
have
been
attributed
to
abnormalities
in
the
connections
of
neural
circuits.
Exploration
circuits
may
give
enlightenment
treating
some
intractable
diseases.
Here,
we
screened
all
publications
on
Web
Science
database
from
2007
2022
and
analyzed
research
trends
through
VOSviewer,
CiteSpace,
Microsoft
Excel
2019,
Origin.
The
findings
revealed
a
consistent
upward
trend
during
this
period.
United
States
emerged
as
leading
contributor,
followed
by
China
Japan.
Among
top
10
institutions
with
largest
number
publications,
both
strong
presence.
Notably,
Chinese
Academy
Sciences
demonstrated
highest
publication
output,
closely
Stanford
University.
In
terms
influential
authors,
Karl
Deisseroth
stood
out
one
most
prominent
investigators.
During
period,
majority
citations
circuit
were
found
highly
journals
including
NEURON,
NATURE
JOURNAL
OF
NEUROSCIENCE,
so
forth.
Keyword
clustering
analysis
highlighted
increasing
focus
photogenetics
neuroscience
research,
reconstruction
has
crucial
direction
science.
conclusion,
over
past
15
years,
high‐quality
facilitated
development
circuits,
indicating
promising
prospect
for
investigations
neurological
psychiatric
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 2, 2024
The
development
of
neuronal
circuits
is
an
activity-dependent
process.
Research
aimed
at
deciphering
the
learning
rules
governing
these
developmental
refinements
increasingly
utilizing
a
class
chemogenetic
tools
that
employ
Gi/o
protein
signaling
(Gi-DREADDs)
for
silencing.
However,
their
mechanisms
action
and
inhibitory
efficacy
in
immature
neurons
with
incompletely
developed
are
poorly
understood.
Here,
we
analyze
impact
on
cellular
network
excitability
neonatal
hippocampus
by
expressing
Gi-DREADD
hM4Di
telencephalic
glutamatergic
mice
both
sexes.
Using
acousto-optic
two-photon
Ca2+
imaging,
report
activation
leads
to
complete
arrest
spontaneous
synchronized
activity
CA1
vitro.
Electrophysiological
analyses
demonstrate
hM4Di-mediated
silencing
not
accounted
changes
intrinsic
pyramidal
cells
(PCs).
Instead,
robustly
restrains
synaptic
glutamate
release
first
postnatal
week,
effectively
reducing
recurrent
excitation
CA1.
In
vivo,
inhibition
through
potently
suppresses
early
sharp
waves
(eSPWs)
discontinuous
oscillatory
head-fixed
before
eye
opening.
summary,
dampens
neurotransmission
presynaptic
mechanism
sufficient
terminate
Our
findings
have
implications
designing
interpreting
experiments
Gi-DREADDs
further
point
potential
role
Gi/o-dependent
endogenous
neuromodulators
hippocampal
development.
Reviews in the Neurosciences,
Journal Year:
2024,
Volume and Issue:
35(6), P. 639 - 650
Published: April 5, 2024
Abstract
While
breathing
is
a
vital,
involuntary
physiological
function,
the
mode
of
respiration,
particularly
nasal
breathing,
exerts
profound
influence
on
brain
activity
and
cognitive
processes.
This
review
synthesizes
existing
research
interactions
between
respiration
entrainment
oscillations
across
regions
involved
in
cognition.
The
rhythmic
activation
olfactory
sensory
neurons
during
linked
to
widespread
regions,
including
prefrontal
cortex,
entorhinal
hippocampus,
amygdala,
parietal
as
well
piriform
cortex.
phase-locking
neural
respiratory
cycle,
through
enhances
inter-regional
communication
associated
with
abilities
like
memory.
Understanding
impact
networks
offers
opportunities
explore
novel
methods
for
targeting
pathway
means
enhance
emotional
functions.
Royal Society of Chemistry eBooks,
Journal Year:
2024,
Volume and Issue:
unknown, P. 133 - 155
Published: Dec. 6, 2024
This
chapter
provides
an
overview
of
the
current
understanding
aromatherapy,
its
application
to
neurodegenerative
diseases
and
schizophrenia,
observed
effects.
It
further
explores
relationship
between
aromatherapy
neurobiology,
including
structural
features
olfactory
receptors,
signal
transmission,
distribution
in
brain.
The
transitions
into
neuroanatomy,
functioning
human
brain,
connection
limbic
system
olfactometry,
assessment
functions
schizophrenia.
Olfactory
schizophrenia
are
discussed,
comparing
brain
rodent
brains,
describing
challenges
research.
Areas
that
not
yet
fully
understood
but
presumed
be
involved
also
examined,
along
with
methods
utilized
for
research
(EEG,
PET,
fMRI),
genetic
engineering,
swabs,
psychometric
questionnaires.
