Electrical signaling and coordinated behavior in the closest relative of animals

Science Advances, Journal Year: 2025, Volume and Issue: 11(2)

Published: Jan. 8, 2025

The transition from simple to complex multicellularity involves division of labor and specialization cell types. In animals, sensory-motor systems are primarily built around specialized cells muscles neurons, though the evolutionary origins these their integration remain unclear. Here, investigate sensory-behavior coupling in closest relatives we established a line choanoflagellate, Salpingoeca rosetta, which stably expresses calcium indicator RGECO1. Using this, identify previously unknown cellular behavior associated with electrical signaling, ciliary arrest is coupled apical-basal contraction cell. This transients synchronized multicellular state result coordinated colony-wide contraction, suggesting that information spread among cells. Our work reveals fundamental insights into how choanoflagellates sense respond environment enhances our understanding organism-wide protistan animals.

Language: Английский

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Inwardly rectifying potassium channels regulate membrane potential polarization and direction sensing during neutrophil chemotaxis

Published: March 6, 2025

Abstract Potassium channels regulate membrane potential and diverse physiological processes, including cell migration. However, the specific function of inwardly rectifying potassium in immune chemotaxis is unknown. Here, we identified that channel Kir7.1 (KCNJ13) maintains resting required for directional sensing during neutrophil chemotaxis. Pharmacological or genetic inhibition neutrophils impaired direction toward various chemoattractants without affecting polarization multiple models. Using genetically encoded voltage indicators, observed oscillating depolarization protrusions zebrafish neutrophils, polarized towards chemokine source. Focal with optogenetic tools biases pseudopod selection induces de novo protrusions. Global hyperpolarizing stalled Furthermore, regulates GPCR signaling activation. This work adds to intricate feedforward mechanism, coupling adaptive excitable network steer cells complex tissue environments.

Language: Английский

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Biased Lévy Walk Enables Light Gradient Sensing in Euglena gracilis

Physical Review Letters, Journal Year: 2025, Volume and Issue: 134(10)

Published: March 13, 2025

We examine the navigation behavior of photosensitive alga Euglena gracilis in confined environments. Under uniform lighting conditions, E. exhibits stochastic movements with nearly straight runs interrupted by abrupt directional changes. The lengths these follow a long-tailed distribution typical L\'evy walk, scaling exponents that vary light intensity. In gradient cells modulate their run durations---extending them upon detecting an increase intensity and shortening when decrease is detected. This adjustment effectively biases enabling to ascend spatial gradient. mirrors well-known prokaryotic strategies, such as bacterial chemotaxis, offering eukaryotic parallel. experimental observations under varied conditions are consistently replicated through agent-based model.

Language: Английский

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Electrical signaling and coordinated behavior in the closest relative of animals

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 21, 2024

Abstract The transition between simple to complex multicellularity involves large degrees of division labor and specialization cell types. In animals, sensory motor systems are primarily built around the fundamental types muscles neurons, though evolutionary origin these cells, their integration, remains unclear. Here, in order investigate sensory-behavior coupling closest relatives we established a line choanoflagellate, Salpingoeca rosetta , which stably expresses calcium indicator RGECO1. Using this, identify novel cellular behavior associated with electrical signaling, ciliary arrest is coupled apical-basal contraction cell. This behavior, transients, synchronized multicellular state result coordinated colony wide contraction, suggesting information spread amongst cells. Our work reveals insights into how choanoflagellates sense respond environment offer new perspective integration organism protistan animals.

Language: Английский

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Minimal design of a synthetic cilium

Physical Review Research, Journal Year: 2024, Volume and Issue: 6(4)

Published: Dec. 12, 2024

We study a slender filament beating in viscous fluid with novel curvature-dependent bending stiffness. Our numerical and experimental investigations reveal that such differential stiffness can sustain planar waves far along flexible filaments, stark contrast to the uniform-stiffness case which requires more sophisticated control. In particular, we establish basal actuation as viable, parsimonious mechanism for generating high-amplitude waves. Moreover, resulting beat patterns closely resemble power-and-recovery strokes of propulsive biological filaments cilia, suggesting extensive applications robotic engineered systems. Published by American Physical Society 2024

Language: Английский

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A QR Code for the Brain: A dynamical systems framework for computing neurophysiological biomarkers

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Neural circuits are often considered the bridge connecting genetic causes and behavior. Whereas prenatal neural believed to be derived from a combination of intrinsic activity, postnatal largely influenced by exogenous activity experience. A dynamical neuroelectric field maintained is proposed as fundamental information processing substrate cognitive function. Time series measurements can collected scalp sensors used mathematically quantify essential features constructing digital twin system phase space. The multiscale nonlinear values that result organized into tensor data structures, which latent extracted using factorization. These mapped behavioral constructs derive biomarkers. This computational framework provides robust method for incorporating neurodynamical measures neuropsychiatric biomarker discovery.

Language: Английский

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Biophysics of protist behaviour

Current Biology, Journal Year: 2024, Volume and Issue: 34(20), P. R981 - R986

Published: Oct. 1, 2024

Language: Английский

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Cell motility: Bioelectrical control of behavior without neurons

Current Biology, Journal Year: 2024, Volume and Issue: 34(4), P. R137 - R140

Published: Feb. 1, 2024

Language: Английский

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