Cellular cruise control: energy expenditure as a regulator of collective migration in epithelia DOI Creative Commons
Isaac B. Breinyn,

Simon F. Martina-Perez,

Ruth E. Baker

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Abstract Epithelial migration is implicit in processes ranging from gastrula development to the healing of skin, and involves coordinated motion, force production, resulting energy expenditure thousands constitutive cells. However, spatiotemporal patterning regulation during epithelial remains poorly understood. Here, we propose a continuum mechan-ics framework use it explore how regulates migration. We canonical mechanical metrics such as force, work power define what means for tissue migrate ‘efficiently’ show that freely expanding epithelia actively regulate themselves operate within maximally efficient regime. then leverage electrotaxis (directed motion response an externally applied electric field) tool study non-homeostatic migra-tion using this new framework. robust external cues acts attenuate tissues stimuli.

Language: Английский

Ultrastructural Localization of Glutamate Delta Receptor 1 in the Rodent and Primate Lateral Habenula DOI Creative Commons
Diane Choi, Jean‐François Paré, Shashank M. Dravid

et al.

The Journal of Comparative Neurology, Journal Year: 2025, Volume and Issue: 533(1)

Published: Jan. 1, 2025

ABSTRACT Glutamate delta receptor 1 (GluD1) is a unique synaptogenic molecule expressed at excitatory and inhibitory synapses. The lateral habenula (LHb), subcortical structure that regulates negative reward prediction error major monoaminergic systems, enriched in GluD1. LHb dysfunction has been implicated psychiatric disorders such as depression schizophrenia, both of which are associated with GRID1 , the gene encodes Thus, disruption GluD1 synaptic signaling may contribute to pathophysiology LHb‐associated disorders. Despite its strong cellular expression, little known about subsynaptic subcellular localization neurons. Given involved development and/or regulation glutamatergic GABAergic synapses various brain regions, detailed map essential elucidate role LHb. To address this issue, we used immunoelectron microscopy methods rodents monkeys. In species, immunoreactivity was primarily dendritic profiles, lower expression somata, spines, glial elements. Pre‐ post‐embedding immunogold experiments revealed core symmetric Albeit less frequent, also found edges (i.e., perisynaptic) asymmetric, putative Through combination anterograde tracing labeling rats, showed axon terminals from entopeduncular nucleus hypothalamus express postsynaptic immunolabeling Our findings suggest play critical modulating transmission rodent primate

Language: Английский

Citations

0
PFDN1 silencing disrupts critical cancer pathways in triple-negative breast cancer: investigating migration, cell cycle, and apoptosis as a new target therapy DOI

Abdulrahman M. Alokda,

Ahmed Soffar,

Amany I. Yousef

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Sec61β, a subunit of the Sec61 complex at the endoplasmic reticulum, coordinates with Ocnus in regulating Drosophila spermatogenesis DOI

Qian Wang,

Xin Chen, Yu‐Feng Wang

et al.

Insect Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 104310 - 104310

Published: April 1, 2025

Language: Английский

Citations

0
Sorting and characterization of cancer cells with different migration phenotypes using a microfluidic platform DOI

Shihui Ding,

Wenyong Ding,

Xuan Wang

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137875 - 137875

Published: April 1, 2025

Language: Английский

Citations

0
Cell migration: Collective cell migration is intrinsically stressful DOI Creative Commons
Heng Wang, Jiong Chen

Current Biology, Journal Year: 2024, Volume and Issue: 34(7), P. R275 - R278

Published: April 1, 2024

Language: Английский

Citations

0
Cellular cruise control: energy expenditure as a regulator of collective migration in epithelia DOI Creative Commons
Isaac B. Breinyn,

Simon F. Martina-Perez,

Ruth E. Baker

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 21, 2024

Abstract Epithelial migration is implicit in processes ranging from gastrula development to the healing of skin, and involves coordinated motion, force production, resulting energy expenditure thousands constitutive cells. However, spatiotemporal patterning regulation during epithelial remains poorly understood. Here, we propose a continuum mechan-ics framework use it explore how regulates migration. We canonical mechanical metrics such as force, work power define what means for tissue migrate ‘efficiently’ show that freely expanding epithelia actively regulate themselves operate within maximally efficient regime. then leverage electrotaxis (directed motion response an externally applied electric field) tool study non-homeostatic migra-tion using this new framework. robust external cues acts attenuate tissues stimuli.

Language: Английский

Citations

0