Gustatory Thalamic Neurons Mediate Aversive Behaviors DOI Creative Commons
Feng Cao, Sekun Park, Jordan L. Pauli

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

ABSTRACT The parvicellular part of the ventral posteromedial nucleus (VPMpc) thalamus, also known as gustatory receives input from parabrachial and relays taste sensation to (or insular) cortex. Prior research has focussed on role VPMpc in relaying signals. Here we provide evidence showing that mediates aversive behaviors. By recording calcium transients vivo single neurons mice, show expressing cholecystokinin mu-opioid receptor respond various noxious stimuli fear memory. Chemogenetic optogenetic activation these enhances response stimuli, whereas silencing them attenuates directly innervate insular cortex rostral lateral amygdala. This study expands include mediating threating signals

Language: Английский

Antipruritic Effects of Single Administration of Paroxetine on Acute and Chronic Itch DOI Open Access

Kosuke Matsuda,

Hikaru Ishisaka,

Masahito Sawahata

et al.

Biological and Pharmaceutical Bulletin, Journal Year: 2025, Volume and Issue: 48(2), P. 184 - 187

Published: Feb. 27, 2025

Itch is described as an unpleasant sensation, and chronic itch, such that in atopic dermatitis (AD), often decreases a patient's QOL. There are few effective treatments for various pruritic disorders not limited to inflammation. Selective serotonin reuptake inhibitors (SSRIs) antidepressants used treat some pruritus disorders. However, there little evidence from clinical basic studies using animal models. In this study, we found paroxetine suppressed acute itch mouse Single administration of (10 mg/kg) inhibited scratching behavior caused by histamine-dependent or histamine-independent itch. Moreover, spontaneous AD model NC/Nga mice without affecting locomotor function. These results suggest suppresses via -independent pathways. This study provides one the pieces SSRIs suppress

Language: Английский

Citations

0
The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats DOI Creative Commons
Xingyu Lu,

Jun-Fei Teng,

Juan Yao

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 223, P. 111283 - 111283

Published: Feb. 28, 2025

Language: Английский

Citations

0
Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons DOI
Ouyang Zhanmu,

Yang Yang,

Bin Feng

et al.

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Language: Английский

Citations

1
Gustatory Thalamic Neurons Mediate Aversive Behaviors DOI Creative Commons
Feng Cao, Sekun Park, Jordan L. Pauli

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

ABSTRACT The parvicellular part of the ventral posteromedial nucleus (VPMpc) thalamus, also known as gustatory receives input from parabrachial and relays taste sensation to (or insular) cortex. Prior research has focussed on role VPMpc in relaying signals. Here we provide evidence showing that mediates aversive behaviors. By recording calcium transients vivo single neurons mice, show expressing cholecystokinin mu-opioid receptor respond various noxious stimuli fear memory. Chemogenetic optogenetic activation these enhances response stimuli, whereas silencing them attenuates directly innervate insular cortex rostral lateral amygdala. This study expands include mediating threating signals

Language: Английский

Citations

1