Rigidity of epithelial tissues as a double optimization problem

Physical Review Research, Journal Year: 2025, Volume and Issue: 7(1)

Published: Feb. 12, 2025

How do cells tune emergent properties at the scale of tissues? One class such behaviors are rigidity transitions, in which a tissue changes from solidlike to fluidlike state or vice versa. Here we introduce way for described by vertex model its using “tunable degrees freedom.” We use elastic energy as cost function and cell stiffnesses, target shapes, areas different sets freedom describing cell-cell interactions that can be tuned minimize function. show transition is unaffected when stiffnesses treated tunable freedom. When preferred shapes freedom, however, induced spatial correlations shift transition. These observations suggest tissues coordinate cell-scale properties, here achieve desired tissue-scale behaviors. Published American Physical Society 2025

Language: Английский

Synchronization in epithelial tissue morphogenesis

Current Biology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

EGFR-dependent actomyosin patterning coordinates morphogenetic movements between tissues in Drosophila melanogaster

Developmental Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский