Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration DOI Creative Commons
Shouhong Wang,

Liezhen Fu,

Bin Wang

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 31, 2024

Thyroid hormone (T3) has an inhibitory effect on tissue/organ regeneration. It is still elusive how T3 regulates this process. well established that the developmental effects of are primarily mediated through transcriptional regulation by thyroid receptors (TRs). Here we have taken advantage mutant tadpoles lacking both TRα and TRβ (TRDKO), only receptor genes in vertebrates, for RNA-seq analyses to investigate transcriptome changes underlying initiation tail regeneration, i.e., wound healing blastema formation, because crucial initial step determines extent functional regeneration later phase tissue regrowth.

Language: Английский

Wound healing: Surprising support from distant sources DOI
Ivonne M. Sehring, Gilbert Weidinger

Current Biology, Journal Year: 2024, Volume and Issue: 34(16), P. R774 - R776

Published: Aug. 1, 2024

Language: Английский

Citations

0
Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration DOI Creative Commons
Georgios Tsissios, Marion Leleu, Kelly Hu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Why mammals cannot regenerate limbs, unlike amphibians, presents a longstanding puzzle in biology. We show that exposing ex vivo amputated embryonic mouse limbs to subatmospheric oxygen environment, or stabilizing oxygen-sensitive HIF1A enables not only rapid wound healing, but alters cellular mechanics, and reshapes the histone landscape prime regenerative fates. Conversely, Xenopus tadpole display low oxygen-sensing capacity, robust landscape, glycolytic programs even under high oxygen. This reduced stark contrast mammals, associates with decreased HIF1A-regulating gene expressions. Our findings thus uncover species-specific sensing as unifying mechanism for limb regeneration initiation across vertebrates, reveal how aquatic habitats may enhance capabilities, identify targetable barriers unlock latent adult mammals.

Language: Английский

Citations

0
Zebrafish tailfin as an in vivo model for capturing tissue-scale cell dynamics DOI
Yue Rong Tan, Hsiao-Yuh Roan, Chen‐Hui Chen

et al.

Seminars in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 166, P. 29 - 35

Published: Dec. 25, 2024

Language: Английский

Citations

0
Thyroid hormone receptor- and stage-dependent transcriptome changes affect the initial period of Xenopus tropicalis tail regeneration DOI Creative Commons
Shouhong Wang,

Liezhen Fu,

Bin Wang

et al.

BMC Genomics, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 31, 2024

Thyroid hormone (T3) has an inhibitory effect on tissue/organ regeneration. It is still elusive how T3 regulates this process. well established that the developmental effects of are primarily mediated through transcriptional regulation by thyroid receptors (TRs). Here we have taken advantage mutant tadpoles lacking both TRα and TRβ (TRDKO), only receptor genes in vertebrates, for RNA-seq analyses to investigate transcriptome changes underlying initiation tail regeneration, i.e., wound healing blastema formation, because crucial initial step determines extent functional regeneration later phase tissue regrowth.

Language: Английский

Citations

0