Play-like behavior exhibited by the vinegar fly Drosophila melanogaster
Current Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 1, 2025
Language: Английский
Pleiotropic neurotransmitters: neurotransmitter-receptor crosstalk regulates excitation-inhibition balance in social brain functions and pathologies
Frontiers in Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: March 14, 2025
Neuronal
excitation-inhibition
(E/I)
balance
is
essential
for
maintaining
neuronal
stability
and
proper
brain
functioning.
Disruptions
in
this
are
implicated
various
neurological
disorders,
including
autism
spectrum
disorder,
schizophrenia
epilepsy.
The
E/I
thought
to
be
primarily
mediated
by
intrinsic
excitability,
governed
an
array
of
voltage-gated
ion
channels,
extrinsic
maintained
through
a
counterbalance
between
excitatory
synaptic
transmission
transmitter
glutamate
acting
on
ion-tropic
receptors
inhibitory
transmissions
chiefly
GABA
or
glycine
their
respective
receptors.
However,
recent
studies
reveal
that
neurotransmitters
can
exhibit
interactions
extend
beyond
traditional
targets,
leading
phenomenon
called
neurotransmitter-receptor
crosstalk.
Examples
such
crosstalks
include
earlier
discovery
functioning
as
co-transmitter
gating
the
NMDA
subtype
receptor,
most
demonstration
shows
binds
GABAA
thereby
allosterically
potentiating
its
function.
These
demonstrate
structurally
physiologically
important
crosstalk
transmission,
blurring
distinction
concepts
classic
transmission.
In
article,
evidence
supporting
forms
will
briefly
summarized
underlying
mechanisms
discussed.
Furthermore,
review
discuss
implications
these
balance,
well
potential
involvement
plasticity
cognition
context
social
conditions.
Language: Английский
Play behavior
Elsevier eBooks,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
The Neurobiology of Ticklishness
Neuroscience Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Ticklishness
is
an
idiosyncratic
form
of
touch
observed
in
multiple
animal
species,
including
humans.
Although
commonly
regarded
as
trivial,
it
involves
complex
neurobiological
mechanisms
and
diverse
behavioral
phenomena
across
species.
Two
distinct
forms
exist:
knismesis,
a
mild
tingling
sensation
elicited
by
gentle
touch,
gargalesis,
intense
associated
with
involuntary
laughter.
Advocating
the
importance
clearly
distinguishing
these
two
types
ticklishness,
this
review
synthesizes
current
knowledge
on
their
neuronal
underpinnings.
Topics
include
somatosensory
processing,
self-tickling
sensory
attenuation,
emotional
modulation,
sociosexual
dimensions,
evolutionary
perspectives,
among
others.
Special
attention
given
to
ambivalent
nature
challenging
conventional
single-dimensional
models
valence.
Ultimately,
studying
ticklishness
provides
valuable
opportunity
investigate
playful
experiences
from
naturalistic
perspective,
addressing
fundamental
yet
underrepresented
questions
contemporary
neuroscience.
Far
thus
insights
into
neural
underlying
complex,
context-dependent
social
experiences.
Language: Английский
OVA-Induced Food Allergy Leads to Neurobehavioral Changes in Mice and the Potential Role of Gut Microbiota and Metabolites Dysbiosis
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(10), P. 4760 - 4760
Published: May 16, 2025
The
neurobehavioral
changes
in
food
allergy
mice
have
not
been
comprehensively
studied,
and
the
mechanism
underlying
them
remains
unclear.
Our
study
aims
to
fully
investigate
OVA
(ovalbumin)-sensitized
explore
potential
via
gut
microbiota-brain
axis.
We
established
mouse
(C57BL/6J
male)
model
with
OVA,
evaluating
anaphylactic
symptoms
levels
of
Th2
signature
cytokine
allergy-related
antibodies
serum.
Using
behavioral
tests,
we
measured
anxiety,
depression,
social
behavior,
repetitive
attention,
spatial
memory
control
mice.
In
addition,
analyzed
prefrontal
cortex
for
measuring
inflammation-related
indicators
gathered
serum
untargeted
metabolomics
analysis
feces
16S
rDNA
sequencing.
exhibited
significantly
elevated
IgE
levels.
addition
anxiety-like,
depression-like,
behaviors,
also
displayed
less
interest
damaged
attention.
TNF-α,
IL-1β,
IL-6
activation
microglia
were
increased,
which
might
explain
neuronal
damage.
multi-omics
technology,
amino
acid
metabolism
disruption,
particularly
carboxylic
acids
derivatives,
was
observed
mice,
remarkably
correlated
altered
abundance
microbiota
related
allergy.
Behaviors
OVA-induced
extensively
impaired.
disruption
associated
dysbiosis
play
a
pivotal
role
impairing
neural
immune
homeostasis
damage,
could
be
responsible
abnormalities.
Language: Английский
Play behavior: Why do adults play less than juveniles?
Current Biology,
Journal Year:
2024,
Volume and Issue:
34(16), P. R784 - R786
Published: Aug. 1, 2024
Language: Английский
The transcriptome of playfulness is sex-biased in the juvenile rat medial amygdala: a role for inhibitory neurons
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 11, 2024
Social
play
is
a
dynamic
behavior
known
to
be
sexually
differentiated;
in
most
species,
males
more
than
females,
sex
difference
driven
large
part
by
the
medial
amygdala
(MeA).
Despite
well-conserved
nature
of
this
and
importance
social
for
appropriate
maturation
brain
behavior,
full
mechanism
establishing
bias
unknown.
Here,
we
explore
"the
transcriptome
playfulness"
juvenile
rat
MeA,
assessing
differences
gene
expression
between
high-
low-playing
animals
both
sexes
via
bulk
RNA-sequencing.
Using
weighted
co-expression
network
analysis
(WGCNA)
identify
modules
combined
with
differentially
expressed
genes
(DEGs),
demonstrate
that
transcriptomic
profile
MeA
associated
playfulness
largely
distinct
compared
females.
Of
13
play-associated
WGCNA
networks
identified,
only
two
were
sexes,
very
few
DEGs
shared
Data
from
our
parallel
single-cell
RNA-sequencing
experiments
using
samples
newborn
male
female
rats
suggests
inhibitory
neurons
drive
difference,
as
majority
sex-biased
neonatal
are
enriched
within
population.
Supporting
notion,
comprise
play-active
cells
having
greater
number
which
larger
proportion
GABAergic.
Through
integrative
bioinformatic
analyses,
further
expression,
function,
cell-type
specificity
key
regulator
"hub
genes"
predicted
them,
providing
valuable
insight
into
mechanisms
underlying
fundamental
behavior.
Language: Английский