Current Biology, Journal Year: 2024, Volume and Issue: 34(18), P. R854 - R856
Published: Sept. 1, 2024
Language: Английский
Current Biology, Journal Year: 2024, Volume and Issue: 34(18), P. R854 - R856
Published: Sept. 1, 2024
Language: Английский
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Dendrites grow by stochastic branching, elongation, and retraction. A key question is whether such a mechanism sufficient to form highly branched dendritic morphologies. Alternatively, are signals from other cells or the topological hierarchy of growing network necessary for dendrite geometry? To answer these questions, we developed mean-field model in which branch dynamics isotropic homogenous (i.e., no extrinsic instruction) depends only on average lengths densities branches. Branching modeled as density-dependent nucleation so there tree structures topology. Despite its simplicity, predicted several morphological properties class IV Drosophila sensory dendrites, including exponential distribution lengths, parabolic scaling between number length densities, tight spacing meshwork (which required minimal total length), radial orientation Stochastic growth also accelerated overall expansion rate arbor. Therefore, an economical rapid space-filling building arbors without external guidance hierarchical branching mechanisms. Our provides general theoretical framework understanding how macroscopic patterns emerge microscopic dynamics.
Language: Английский
Citations
0iScience, Journal Year: 2023, Volume and Issue: 26(7), P. 107238 - 107238
Published: July 1, 2023
Clustered protocadherin (Pcdh), a cell adhesion protein, is involved in the self-recognition and non-self-discrimination of neurons by conferring diversity on surface. Although roles Pcdh have been elucidated, it has challenging to visualize its activity neurons, which molecular function Pcdh. Here, we present fluorescent indicators, named IPADs, interaction protocadherin-α4 isoform (α4). IPADs successfully not only homophilic α4
Language: Английский
Citations
2Current Biology, Journal Year: 2024, Volume and Issue: 34(18), P. R854 - R856
Published: Sept. 1, 2024
Language: Английский
Citations
0