Macroevolutionary changes in gene expression response to an immune stimulus across the diversity of fishes DOI Creative Commons
Ben A. Flanagan, Lauren E. Fuess, Milan Vrtílek

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Our understanding of the vertebrate immune system is dominated by a few model organisms such as mice. This use systems reasonable if major features evolve slowly and are conserved across most vertebrates, but may be problematic there substantial macroevolutionary change in responses. Here, we present test stability, 15 species jawed fishes, transcriptomic response to standardized challenge. Intraperitoneal injection an adjuvant (alum) induces fibrosis nearly all which some contributes anti-helminth resistance. Despite this phenotypic response, underlying highly inconsistent species. Although many gene orthogroups exhibit differential expression between saline versus alum-injected fish at least one species, consistent result suggests that although alum (fibrosis) conserved, regulatory architecture very flexible cannot readily extrapolated from any fishes (or vertebrates) more broadly. The remarkably changeable over time, requiring diversity describe effectively.

Language: Английский

Integrative analyses of convergent adaptation in sympatric extremophile fishes DOI
Ryan Greenway, Rishi De‐Kayne, Anthony P. Brown

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(21), P. 4968 - 4982.e7

Published: Oct. 11, 2024

Language: Английский

Citations

6

DNA Methylation Regulates Somatic Stress Memory and Mediates Plasticity during Acclimation to Repeated Sulfide Stress in Urechis unicinctus DOI
Wenqing Zhang, Long Zhang, Wenwen Jiang

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137264 - 137264

Published: Jan. 17, 2025

Language: Английский

Citations

0

Evolutionary Rate Shifts in Coding and Regulatory Regions Underpin Repeated Adaptation to Sulfidic Streams in Poeciliid Fishes DOI Creative Commons
Rishi De‐Kayne, Blair W. Perry, Kerry L. McGowan

et al.

Genome Biology and Evolution, Journal Year: 2024, Volume and Issue: 16(5)

Published: May 1, 2024

Abstract Adaptation to extreme environments often involves the evolution of dramatic physiological changes. To better understand how organisms evolve these complex phenotypic changes, repeatability and predictability evolution, possible constraints on adapting an environment, it is important adaptive variation has evolved. Poeciliid fishes represent a particularly fruitful study system for investigations adaptation due their repeated colonization toxic hydrogen sulfide–rich springs across multiple species within clade. Previous have highlighted changes in physiology gene expression specific that are thought facilitate springs. However, presence nucleotide coding regulatory regions degree which convergent shaped genomic underpinning sulfide tolerance taxa unknown. By sampling seven independent lineages nonsulfidic colonized adapted springs, we reveal signatures shared evolutionary rate shifts genome. We found evidence genes, promoters, putative enhancer associated with both increased decreased sulfide–adapted lineages. Our analysis highlights sulfidic modulation endogenous production detoxification. also shifted rates spring more exhibited either region or sequence given gene, rather than both.

Language: Английский

Citations

3

Adaptations in surprising places DOI
Kimberly A. Rosvall

Science, Journal Year: 2025, Volume and Issue: 387(6732), P. 358 - 359

Published: Jan. 23, 2025

Testosterone is controlled while it circulates in the bloodstream

Language: Английский

Citations

0

Evolution: Repeat adaptation in the hot spring DOI
Magdalena Bohutínská

Current Biology, Journal Year: 2024, Volume and Issue: 34(21), P. R1081 - R1083

Published: Nov. 1, 2024

Language: Английский

Citations

0

Macroevolutionary changes in gene expression response to an immune stimulus across the diversity of fishes DOI Creative Commons
Ben A. Flanagan, Lauren E. Fuess, Milan Vrtílek

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract Our understanding of the vertebrate immune system is dominated by a few model organisms such as mice. This use systems reasonable if major features evolve slowly and are conserved across most vertebrates, but may be problematic there substantial macroevolutionary change in responses. Here, we present test stability, 15 species jawed fishes, transcriptomic response to standardized challenge. Intraperitoneal injection an adjuvant (alum) induces fibrosis nearly all which some contributes anti-helminth resistance. Despite this phenotypic response, underlying highly inconsistent species. Although many gene orthogroups exhibit differential expression between saline versus alum-injected fish at least one species, consistent result suggests that although alum (fibrosis) conserved, regulatory architecture very flexible cannot readily extrapolated from any fishes (or vertebrates) more broadly. The remarkably changeable over time, requiring diversity describe effectively.

Language: Английский

Citations

0