Developmental rewiring of the NGAL/CUC/KLU network associated with pleiotropic roles of NGAL genes DOI Creative Commons
Antoine Nicolas, Panagiotis Papadopoulos,

Mattéo Caroulle

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Abstract Gene Regulatory Networks (GRNs) play prominent roles in regulating developmental processes, and their modulation across species is a major source for evolutionary innovation. However, it remains poorly understood how GRNs are rewired between different organs within single species. This question particularly relevant pleiotropic genes, which may exhibit organ-specific GRN modulations potentially reflecting diverse functions. To address this, we investigated the NGATHA-like ( NGAL ) as model genes that regulate growth or patterning multiple Arabidopsis via two distinct pathways involving CUP-SHAPED COTYLEDON CUC KLUH KLU genes. By combining genetic analysis with gene expression characterization, uncovered significant rewiring of / regulatory module. Our findings highlight changes patterns, arising from constraints, pivotal role GRNs. Furthermore, at molecular functional levels do not always align perfectly, due to influence additional mechanisms. Altogether, our reveal associated We propose this flexibility facilitates pleiotropy.

Language: Английский

The developmental and genetic basis of male genitalia evolution in Drosophilids DOI Creative Commons

Milton Urum,

Ella Preger‐Ben Noon

Current Opinion in Insect Science, Journal Year: 2025, Volume and Issue: unknown, P. 101335 - 101335

Published: Jan. 1, 2025

Language: Английский

Citations

2
Evolution of gene regulatory networks in insects DOI
Takumi Karasawa, Shigeyuki Koshikawa

Current Opinion in Insect Science, Journal Year: 2025, Volume and Issue: 69, P. 101365 - 101365

Published: May 8, 2025

Language: Английский

Citations

0
Developmental evolution in fast-forward: insect male genital diversification DOI Creative Commons
Maria D. S. Nunes, Alistair P. McGregor

Trends in Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

Citations

0
Evolutionary biology: Co-option and the evolution of morphological novelty DOI
Amber M. Ridgway, Alistair P. McGregor

Current Biology, Journal Year: 2024, Volume and Issue: 34(22), P. R1144 - R1146

Published: Nov. 1, 2024

Language: Английский

Citations

0
Developmental rewiring of the NGAL/CUC/KLU network associated with pleiotropic roles of NGAL genes DOI Creative Commons
Antoine Nicolas, Panagiotis Papadopoulos,

Mattéo Caroulle

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Abstract Gene Regulatory Networks (GRNs) play prominent roles in regulating developmental processes, and their modulation across species is a major source for evolutionary innovation. However, it remains poorly understood how GRNs are rewired between different organs within single species. This question particularly relevant pleiotropic genes, which may exhibit organ-specific GRN modulations potentially reflecting diverse functions. To address this, we investigated the NGATHA-like ( NGAL ) as model genes that regulate growth or patterning multiple Arabidopsis via two distinct pathways involving CUP-SHAPED COTYLEDON CUC KLUH KLU genes. By combining genetic analysis with gene expression characterization, uncovered significant rewiring of / regulatory module. Our findings highlight changes patterns, arising from constraints, pivotal role GRNs. Furthermore, at molecular functional levels do not always align perfectly, due to influence additional mechanisms. Altogether, our reveal associated We propose this flexibility facilitates pleiotropy.

Language: Английский

Citations

0