Epidemiological trends and risk factors of CKD-T1DM in children and adolescents across 204 countries and territories (1990–2021) DOI Creative Commons

Beiyan Liu,

Fengrui Li,

Huanxi Cui

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Background Global T1DM incidence in children and adolescents is rising, leading to Chronic Kidney Disease due Type 1 Diabetes Mellitus (CKD-T1DM), a critical public health concern. Severe cases evolve into end-stage kidney disease (ESKD), requiring dialysis or transplantation, severely impacting quality of life imposing substantial burdens. Methods This study used Burden (GBD) data analyze global regional CKD-T1DM incidence, prevalence, mortality, Disability-Adjusted Life Years (DALYs) rates (1990-2021). It calculated age-standardized ratios estimated annual percentage change (EAPC), presenting findings via maps comparing age-specific burdens mortality patterns. Findings From 1990 2021, prevalence increased globally, while DALYs declined. Middle SDI (Socio-Demographic Index) nations saw surge new cases, contrasting with High countries’ success reducing DALYs. Male were higher than those females, notable rises Eastern Europe, Central Latin America, drops East Asia. The 10-14 age group exhibited the 15-19 Interpretation management faces challenges. Future research should focus on SDI-specific needs, resource allocation, awareness, community education. Early detection comprehensive protection are crucial, especially middle low countries high-incidence areas.

Language: Английский

Epidemiological trends and risk factors of CKD-T1DM in children and adolescents across 204 countries and territories (1990–2021) DOI Creative Commons

Beiyan Liu,

Fengrui Li,

Huanxi Cui

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Background Global T1DM incidence in children and adolescents is rising, leading to Chronic Kidney Disease due Type 1 Diabetes Mellitus (CKD-T1DM), a critical public health concern. Severe cases evolve into end-stage kidney disease (ESKD), requiring dialysis or transplantation, severely impacting quality of life imposing substantial burdens. Methods This study used Burden (GBD) data analyze global regional CKD-T1DM incidence, prevalence, mortality, Disability-Adjusted Life Years (DALYs) rates (1990-2021). It calculated age-standardized ratios estimated annual percentage change (EAPC), presenting findings via maps comparing age-specific burdens mortality patterns. Findings From 1990 2021, prevalence increased globally, while DALYs declined. Middle SDI (Socio-Demographic Index) nations saw surge new cases, contrasting with High countries’ success reducing DALYs. Male were higher than those females, notable rises Eastern Europe, Central Latin America, drops East Asia. The 10-14 age group exhibited the 15-19 Interpretation management faces challenges. Future research should focus on SDI-specific needs, resource allocation, awareness, community education. Early detection comprehensive protection are crucial, especially middle low countries high-incidence areas.

Language: Английский

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