A Two-sample Mendelian randomization analysis of the relationship between inflammatory factors and nasopharyngeal carcinoma

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Background Nasopharyngeal carcinoma (NPC) is an important health concern worldwide. Previous studies are susceptible to confounding factors. To solve this problem, study uses Mendelian randomization (MR) discover the causal relationship between inflammatory factors and NPC from a genetic perspective. Methods A two-sample MR analysis was performed using data genome-wide association of 41 NPC. The following methods were used analyze NPC: Inverse-Variance Weighted, MR-Egger, Weighted Median, Simple Mode Median. Steiger test determine direction interaction robustness ensured by means Cochran's Q test, leave-one-out MR-Egger regression analysis. Reverse investigate whether there reverse causality CTS. Results There positive granulocyte colony-stimulating factor (G-CSF) levels (OR: 3.659, 95% CI: 1.398–9.581, P = 0. 008), no pleiotropy or level G-CSF sensitivity showed that results analyses did not contain heterogeneity, horizontal pleiotropy, individual single nucleotide polymorphisms significantly influenced analyses. Conclusion potential risk for may provide new research ideas identifying tumor markers therapeutic targets NPC..

Language: Английский

Role Of Critical Molecules In Proliferation and Apoptosis In Tumoral And Peri-Tumoral Microenvironments Of Gastric Cancer

Pharmedicine journal., Journal Year: 2025, Volume and Issue: 2(1), P. 24 - 30

Published: Feb. 28, 2025

Introduction: Gastric cancers (GC) are one of the main causes cancer-related deaths worldwide. Despite dizzying progress in diagnostic and therapeutic strategies, many GC cases diagnosed at advanced stages. Various signaling pathways have been identified to play vital roles GC. Although importance these has demonstrated, further clinical studies needed. Therefore, expression some proteins tumoral peri-tumoral microenvironments examined this study. Methods: Protein levels were analyzed using Western blotting method tumor non-tumorous tissues from nine sufferers. The Kaplan-Meier was used for log-rank test estimate survival curves examine distribution. Results: It found that overexpression c-MYC, mTOR, AKT alongside decreased degrees AMPK TRAIL tissues. analysis highlighted worse outcomes patients with high mTOR expression, while associated improved survival. Interestingly, a poorer prognosis higher c-MYC highlighting oncogenic role protein through AKT/mTOR pathway. On other hand, implied lack tumor-suppressive properties, most likely due activation. Conclusion: These highlight intricate interplay between GC's carcinogenic mechanisms. Targeting molecules by inhibiting or activating may provide new treatment approaches which can significantly increase sensitivity. Moreover, necessary confirm present results establish integrated therapy approaches.

Language: Английский

Exploring causal relationship between 41 inflammatory cytokines and marginal zone lymphoma: A bidirectional Mendelian randomization study

Open Medicine, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Abstract Purpose Marginal zone lymphoma (MZL) is a rare subtype of non-Hodgkin lymphoma, and its diagnosis primarily relies on pathological biopsy. The study aims to investigate the causal relationships between 41 inflammatory cytokines MZL using two-sample bidirectional Mendelian randomization (MR) approach, providing new insights methodologies for rapid differential treatment strategies. Methods Causal associations were examined genetic variant data from two large-scale genome-wide association studies. inverse variance weighting method was employed, multiple sensitivity analyses, including MR-Egger, weighted median, simple model, model methods, conducted strengthen robustness findings. Results Elevated levels MIG IL-10 associated with an increased risk (MIG: OR = 1.57, p 0.035; IL-10: 1.69, 0.021), while higher B-NGF exhibited protective effect (OR 0.46, 0.027). Reverse MR analysis revealed negative correlation IFN-γ 0.97, 0.015). Conclusions MIG, IL-10, B-NGF, are potential biomarkers therapeutic targets MZL. likely acts as downstream molecule in pathogenesis, offering novel into MZL-related research, clinical diagnosis,

Language: Английский