The impact of metabolic disorders on management of periodontal health in children DOI Creative Commons
Yunyan Zhang, Tong‐Chuan He, Hongmei Zhang

et al.

Pediatric Discovery, Journal Year: 2023, Volume and Issue: 2(1)

Published: Nov. 3, 2023

Abstract Periodontitis is a chronic inflammatory disease caused by plaque biofilm which shares risk factors with systemic diseases such as diabetes, cardiovascular disease, and osteoporosis. Many studies have found increased prevalence rate of progression periodontal in children common metabolic disorders. Although the causal relationship specific mechanism between them has not been determined yet. The aim this paper to progress on impact disorders health underlying mechanisms, provides new evidences for prevention intervention periodontitis children.

Language: Английский

Factors of Obesity and Metabolically Healthy Obesity in Asia DOI Creative Commons
Bryan J. Mathis, Kiyoji Tanaka, Yuji Hiramatsu

et al.

Medicina, Journal Year: 2022, Volume and Issue: 58(9), P. 1271 - 1271

Published: Sept. 13, 2022

The East Asian region (China, Japan, and South Korea) is comprised of almost 1.5 billion people recent industrialization has brought with it a pandemic rising obesity, even in children. As these countries are rapidly aging functioning at sub-replacement birthrates, the burgeoning costs obesity-related care may threaten socialized healthcare systems quality life. However, condition called metabolically healthy obesity (MHO) been found to be without immediate cardiopulmonary or diabetic risk. Thus, maintenance MHO for obese Asia could buffer burden long-term on medical knowledge biochemical, genetic, physiological milieu associated also provide new targets intervention. Diverse physiological, psychological, environmental, social factors play role obesogenesis transition unhealthy obesity. This review will give broad survey various causes MHO, special emphasis population studies from that region.

Language: Английский

Citations

25
New insights into the suppression of inflammation and lipid accumulation by JAZF1 DOI Creative Commons

Wujun Chen,

Yingjie Zhong, Yang Yuan

et al.

Genes & Diseases, Journal Year: 2022, Volume and Issue: 10(6), P. 2457 - 2469

Published: Dec. 2, 2022

Atherosclerosis is one of the leading causes disease and death worldwide. The identification new therapeutic targets agents critical. JAZF1 expressed in many tissues found at particularly high levels adipose tissue (AT). suppresses inflammation (including IL-1β, IL-4, IL-6, IL-8, IL-10, TNFα, IFN-γ, IAR-20, COL3A1, laminin, MCP-1) by reducing NF-κB pathway activation AT immune cell infiltration. reduces lipid accumulation regulating liver X receptor response element (LXRE) SREBP-1c promoter, cAMP-response (CRE) HMGCR, TR4 axis. LXRE CRE sites are present cytokine metabolism gene promoters, which suggests that regulates these genes through sites. center JAZF1-mediated inhibition inflammatory response. expression suppressing TAK1 expression. Interestingly, also decreases accumulation. A dual-targeting strategy could inhibit both Dual-target compounds prodrugs) 1-5 exhibit nanomolar targeting TAK1, EGFR, or COX-2. However, activity relatively low (IC50 > 300 nM). Compounds 6-14 suppress with IC50 values ranging from 1.8 nM to 38.6 nM. HS-276 a highly selective, orally bioavailable inhibitor. Combined structural modifications using prodrug may enhance inhibition. This review focused on role mechanism for anti-atherosclerotic targets.

Language: Английский

Citations

7
Obesity Heterogeneity by Neighborhood Context in a Largely Latinx Sample DOI Creative Commons
Ashley Wendell Kranjac, Dinko Kranjac, Zeev N. Kain

et al.

Journal of Racial and Ethnic Health Disparities, Journal Year: 2023, Volume and Issue: 11(2), P. 980 - 991

Published: March 30, 2023

Abstract Neighborhood socioeconomic context where Latinx children live may influence body weight status. Los Angeles County and Orange of Southern California both are on the list top ten counties with largest population in USA. This heterogeneity allowed us to estimate differential impacts neighborhood environment children’s mass index z -scores by race/ethnicity using novel methods a rich data source. We geocoded pediatric electronic medical record from predominantly sample characterized neighborhoods into unique residential contexts latent profile modeling techniques. estimated multilevel linear regression models that adjust for comorbid conditions found child’s place residence independently associates higher -scores. Interactions further reveal living Middle-Class have BMI than Asian Other Race residing most disadvantaged communities. Our findings underscore complex relationship between community racial/ethnic composition status during childhood.

Language: Английский

Citations

3
Transcriptomic profiling of backfat and muscle in Lijiang pigs with divergent body size across growth stages DOI Creative Commons

S. Fang,

Suyi Luo,

Shan Jin

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 12, 2024

Backfat thickness is an important economic trait that affects pork quality and flavor. The Lijiang pig (LJP), a local breed in Yunnan province, China, exhibits variations growth body composition. However, the molecular basis for these unclear. This study aimed to analyze transcriptome profiles of backfat at different stages LJP with discrepant size: two months (M2), four months, six months. Firstly, we analyzed gene expression differences discovered significantly highest number differentially expressed genes (DEGs) M2 stage. Secondly, identified reverse trends populations sizes, related mainly associated immune response functionality. Thirdly, observed lower correlation large size stage, specific enrichment DEGs high genetic differentiation neural activity. Finally, correlated muscle lowest Highly exhibited more significant were prominently enriched processes. unveils candidate linked LJP, emphasizing specificity early stage backfat.

Language: Английский

Citations

0
The impact of metabolic disorders on management of periodontal health in children DOI Creative Commons
Yunyan Zhang, Tong‐Chuan He, Hongmei Zhang

et al.

Pediatric Discovery, Journal Year: 2023, Volume and Issue: 2(1)

Published: Nov. 3, 2023

Abstract Periodontitis is a chronic inflammatory disease caused by plaque biofilm which shares risk factors with systemic diseases such as diabetes, cardiovascular disease, and osteoporosis. Many studies have found increased prevalence rate of progression periodontal in children common metabolic disorders. Although the causal relationship specific mechanism between them has not been determined yet. The aim this paper to progress on impact disorders health underlying mechanisms, provides new evidences for prevention intervention periodontitis children.

Language: Английский

Citations

1