The impact of COVID-19 on autoimmune diseases

Progress in molecular biology and translational science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

The impact of the mRNA COVID-19 vaccine on the Th-like cytokine profile in individuals with no history of COVID-19: insights into autoimmunity targeting heat shock proteins

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 14, 2025

Although some reports suggest that COVID-19 vaccination may exacerbate existing autoimmune diseases or trigger new-onset cases, a definitive causal relationship between the vaccines and these conditions has not been established. Several potential mechanisms have proposed to explain this association, including: (i) molecular mimicry, which refers structural similarity SARS-CoV-2 human antigens; (ii) bystander activation, involving both B T lymphocytes; (iii) effects of adjuvants. In study, we investigated whether two doses mRNA vaccine influenced blood cytokine levels associated with major helper cell populations, are known play significant role in autoimmunity revisited humoral response directed against heat shock proteins (Hsps) individuals no history COVID-19. While differences were found IFN-γ, IL-6, IL-22, IL-4, IL-8, IL-10, IL-17A, vaccinated unvaccinated people, several positive correlations observed serum circulating autoantibodies self-Hsps exclusively individuals. These findings does impact cytokines involved pathogenesis diseases. Further research is required evaluate safety patients conditions, particularly those whom anti-Hsps suspected contribute disease development.

Language: Английский

ORCHESTRA Delphi consensus: diagnostic and therapeutic management of Post-COVID-19 condition in vulnerable populations

Clinical Microbiology and Infection, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский