The future of amphibian immunology: Opportunities and challenges

Developmental & Comparative Immunology, Journal Year: 2024, Volume and Issue: 160, P. 105237 - 105237

Published: Aug. 3, 2024

Language: Английский

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Constitutive differences in immune gene expression and energy storage phenotypes co-vary with winter environment in wood frogs

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Abstract Many terrestrial ectotherms have gone to great evolutionary lengths adapt long cold winters; some even evolved the ability tolerate freezing of most water in body. Now, however, high-elevation, and high-latitude winters are experiencing an accelerated period warming. Specialized winter adaptations that promoted fitness a seasonally frozen environment may soon be superfluous or maladaptive. We ask whether include changes immune functions, changing conditions could exert disparate effects on populations wide-ranging ectotherm, wood frog ( Lithobates sylvaticus ). By rearing frogs from ancestral environments vary length temperature common garden, reciprocally exposing post-metamorphic unfrozen artificial lab, we were able decompose transcriptomic differences ventral skin gene expression into those environmentally induced (responsive temperature), genetically determined, varied as interaction between genotype environment. found harsh constitutively upregulated processes, including cellular immunity, inflammatory adaptive compared mild environments. Further, saw several genes winter. suggest just climates likely served selective force resulting remarkable such freeze tolerance, they also constitutive expression.

Language: Английский

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Honouring the career of Miodrag (Mike) Belosevic

Developmental & Comparative Immunology, Journal Year: 2023, Volume and Issue: 149, P. 105048 - 105048

Published: Aug. 23, 2023

Language: Английский

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