Immunoglobulin gene loci structure and diversity of raccoon dog (Nyctereutes procyonoides) DOI Creative Commons
Xiaohua Yi,

Yanbo Qiu,

Xiaoqin Tang

et al.

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 29, 2025

In this study, we analyzed the loci structure of raccoon dog genes using a comparative genomics approach. We investigated mechanism expression diversity and its preference Next-generation sequencing. The results indicated that gene were similar to most mammals, with relative abundance V(D)J genes, which ensures diversity. identified following potentially functional genes: 7 VH 6 Vκ 23 Vλ 24 DH 5 JH 4 Jκ Jλ arranged in manner other mammals. Analysis showed have strong for use V same was true genes. main modes recombination somatic hypermutation, high mutation region hypermutation not only concentrated CDR region, but also has FR types G > A, C T, T C, A G. Interestingly, compared differences between normal diseased dogs, there significant (P < 0.05), whereas no expression, utilization preference, recombination, types. summary, described IgH IgL dog, mapped loci, PE300 study could provide theoretical basis an in-depth understanding immunoglobulins, references disease-resistant breeding.

Language: Английский

Immunoglobulin gene loci structure and diversity of raccoon dog (Nyctereutes procyonoides) DOI Creative Commons
Xiaohua Yi,

Yanbo Qiu,

Xiaoqin Tang

et al.

BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)

Published: April 29, 2025

In this study, we analyzed the loci structure of raccoon dog genes using a comparative genomics approach. We investigated mechanism expression diversity and its preference Next-generation sequencing. The results indicated that gene were similar to most mammals, with relative abundance V(D)J genes, which ensures diversity. identified following potentially functional genes: 7 VH 6 Vκ 23 Vλ 24 DH 5 JH 4 Jκ Jλ arranged in manner other mammals. Analysis showed have strong for use V same was true genes. main modes recombination somatic hypermutation, high mutation region hypermutation not only concentrated CDR region, but also has FR types G > A, C T, T C, A G. Interestingly, compared differences between normal diseased dogs, there significant (P < 0.05), whereas no expression, utilization preference, recombination, types. summary, described IgH IgL dog, mapped loci, PE300 study could provide theoretical basis an in-depth understanding immunoglobulins, references disease-resistant breeding.

Language: Английский

Citations

0