Individual differences in internalizing symptoms in late childhood: A variance decomposition into cortical thickness, genetic and environmental differences DOI Creative Commons
Anneli D. Tandberg, Andreas Dahl, Linn B. Norbom

et al.

Developmental Science, Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

The brain undergoes extensive development during late childhood and early adolescence. Cortical thinning is a prominent feature of this development, some researchers have suggested that differences in cortical thickness may be related to internalizing symptoms, which typically increase the same period. However, research has yielded inconclusive results. We utilized new method estimates combined effect individual vertex-wise on symptoms. This approach allows for many small effects distributed across cortex avoids necessity correcting multiple tests. Using sample 8763 children aged 8.9 11.1 from ABCD study, we decomposed total variation caregiver-reported symptoms into thickness, additive genetics, shared family environmental factors unique factors. Our results indicated accounted less than 0.5% In contrast, analysis revealed substantial genetics different components ranging 06% 48% 0% 34%, respectively. Overall, while study found minimal association between familial appear importance describing childhood. RESEARCH HIGHLIGHTS: modelling contribution <0.5% variance Additive 17% 34% suggest not an important indicator childhood, whereas genetic impact.

Language: Английский

The connecting brain in context: How adolescent plasticity supports experiential learning and development DOI Creative Commons
Amanda E. Baker, Adriana Gálvan, Andrew J. Fuligni

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 71, P. 101486 - 101486

Published: Nov. 28, 2024

Language: Английский

Citations

3
Current perspectives on perinatal mental health and neurobehavioral development: focus on regulation, coregulation and self-regulation DOI
Bea Van den Bergh, Marta C. Antonelli, Dan J. Stein

et al.

Current Opinion in Psychiatry, Journal Year: 2024, Volume and Issue: 37(3), P. 237 - 250

Published: Feb. 19, 2024

Perinatal mental health research provides an important perspective on neurobehavioral development. Here, we aim to review the association of maternal perinatal with offspring neurodevelopment, providing update (self-)regulation problems, hypothesized mechanistic pathways, progress and challenges, implications for health.

Language: Английский

Citations

2
Principal component analysis as an efficient method for capturing multivariate brain signatures of complex disorders—ENIGMA study in people with bipolar disorders and obesity DOI Creative Commons
Sean R. McWhinney, Jaroslav Hlinka, Eduard Bakštein

et al.

Human Brain Mapping, Journal Year: 2024, Volume and Issue: 45(8)

Published: June 1, 2024

Multivariate techniques better fit the anatomy of complex neuropsychiatric disorders which are characterized not by alterations in a single region, but rather variations across distributed brain networks. Here, we used principal component analysis (PCA) to identify patterns covariance regions and relate them clinical demographic variables large generalizable dataset individuals with bipolar controls. We then compared performance PCA clustering on identical sample methodology was capturing links between measures. Using data from ENIGMA-BD working group, investigated T1-weighted structural MRI 2436 participants BD healthy controls, applied cortical thickness surface area studied association components using mixed regression models. model our prior analyses same also tested it replication 327 or schizophrenia The first component, indexed greater all 68 regions, negatively associated BD, BMI, antipsychotic medications, age positively Li treatment. demonstrated superior goodness when predicting diagnosis BMI. Moreover, applying yielded significant differences controls schizophrenia. Cortical widespread regional network as determined different variables, including diagnosis, age, treatment medications lithium. outperformed provided an easy-to-use interpret method study multivariate associations structure system-level variables. PRACTITIONER POINTS: In this 2770 Individuals, confirmed that networks relevant Significant many suggest lack one-to-one mapping individual factors specific changes. set group providing for studying

Language: Английский

Citations

2
Individual differences in internalizing symptoms in late childhood: A variance decomposition into cortical thickness, genetic and environmental differences DOI Creative Commons
Anneli D. Tandberg, Andreas Dahl, Linn B. Norbom

et al.

Developmental Science, Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

The brain undergoes extensive development during late childhood and early adolescence. Cortical thinning is a prominent feature of this development, some researchers have suggested that differences in cortical thickness may be related to internalizing symptoms, which typically increase the same period. However, research has yielded inconclusive results. We utilized new method estimates combined effect individual vertex-wise on symptoms. This approach allows for many small effects distributed across cortex avoids necessity correcting multiple tests. Using sample 8763 children aged 8.9 11.1 from ABCD study, we decomposed total variation caregiver-reported symptoms into thickness, additive genetics, shared family environmental factors unique factors. Our results indicated accounted less than 0.5% In contrast, analysis revealed substantial genetics different components ranging 06% 48% 0% 34%, respectively. Overall, while study found minimal association between familial appear importance describing childhood. RESEARCH HIGHLIGHTS: modelling contribution <0.5% variance Additive 17% 34% suggest not an important indicator childhood, whereas genetic impact.

Language: Английский

Citations

0