Change in aperiodic activity over first year of life is associated with later autism diagnosis and 18-month language development in infants with family history of autism DOI Creative Commons
Carol L. Wilkinson, Haerin Chung, Abhishek Dave

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Delays in language often co-occur among toddlers diagnosed with autism. Despite the high prevalence of delays, neurobiology underlying such challenges remains unclear. Prior research has shown reduced EEG power across multiple frequency bands 3-to-6-month-old infants an autistic sibling, followed by accelerated increases age. Here we apply new methods to decompose spectra into aperiodic (broad band neural firing) and periodic (oscillations) activity explore possible links between changes first year life later outcomes. Combining data two longitudinal studies without siblings, assessed whether elevated familial likelihood (EFL) exhibit altered both at 3 12 months age, compared those a low (LL), developmental change is associated development. At 3-months observed that EFL have significantly lower from 6.7-55Hz (p<0.05). However, was increased diagnosis autism, autism diagnosis. In addition, greater offset slope 3-to12-months were worse development measured 18 months. Findings suggest early age-dependent may serve as potential indicators family history

Language: Английский

Resting state EEG in young children with Tuberous Sclerosis Complex: associations with medications and seizures DOI Creative Commons
Caitlin C. Clements, Anne‐Michelle Engelstad, Carol L. Wilkinson

et al.

Journal of Neurodevelopmental Disorders, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 18, 2025

Tuberous Sclerosis Complex (TSC) is a rare genetic condition caused by mutation to TSC1 or TSC2 genes, with population prevalence of 1/7000 births. TSC manifests behaviorally features autism, epilepsy, and intellectual disability. Resting state electroencephalography (EEG) offers window into neural oscillatory activity may serve as an intermediate biomarker between gene expression behavioral manifestations. Such could be useful in clinical trials endpoint predictor treatment response. However, seizures antiepileptic medications also affect resting undermine the utility EEG biomarkers neurodevelopmental disorders such TSC. This paper compares cross-sectional cohort young children (n = 49, ages 12-37 months) 49 age- sex-matched typically developing controls. Within TSC, associations were examined features, seizure severity composite score, use GABA agonists. Compared matched children, showed significantly greater beta power permutation cluster analyses. Children aperiodic offset (reflecting nonoscillatory neuronal firing) after spectra parameterized using SpecParam periodic components. both GABAergic medication independently associated increased peak power. The elevated observed compared controls driven agonist use. It recommended collect data alongside for trials. These results highlight challenge disabilities when epilepsy anti-epileptic are common.

Language: Английский

Citations

2
Adolescent-to-adult gains in cognitive flexibility are adaptively supported by reward sensitivity, exploration, and neural variability DOI Creative Commons
Ashley C. Parr, Valerie J. Sydnor, Finnegan J. Calabro

et al.

Current Opinion in Behavioral Sciences, Journal Year: 2024, Volume and Issue: 58, P. 101399 - 101399

Published: May 10, 2024

Language: Английский

Citations

10
Aperiodic and Hurst EEG exponents across early human brain development: A systematic review DOI Creative Commons
Ryan A. Stanyard, Dan Mason, Claire L. Ellis

et al.

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 68, P. 101402 - 101402

Published: June 7, 2024

In electroencephalographic (EEG) data, power-frequency slope exponents (1/f_β) can provide non-invasive markers of in vivo neural activity excitation-inhibition (E:I) balance. E:I balance may be altered neurodevelopmental conditions; hence, understanding how 1/f β evolves across infancy/childhood has implications for developing early assessments/interventions. This systematic review (PROSPERO-ID: CRD42023363294) explored the maturation (0-26 yrs) resting-state EEG measures (aperiodic [AE], power law [PLE] and Hurst [HE] exponents), including studies containing ≥1 ≥10 typically participants. Five databases (including Embase Scopus) were searched during March 2023. Forty-two identified (Nparticipants=3478). Risk bias was assessed using Quality Assessment with Diverse Studies tool. Narrative synthesis HE data suggests non-stationary occurs throughout development. Age-related trends complex, rapid decreases AEs infancy heterogenous changes thereafter. Regionally, AE maxima shifted developmentally, potentially reflecting spatial maturing brain connectivity. work highlights importance further characterising development to better understand shapes cognitive

Language: Английский

Citations

6
Reevaluating the Neural Noise Hypothesis in Dyslexia: Insights from EEG and 7T MRS Biomarkers DOI Open Access
Agnieszka Glica,

Katarzyna Wasilewska,

Julia Jurkowska

et al.

Published: Jan. 22, 2025

The neural noise hypothesis of dyslexia posits an imbalance between excitatory and inhibitory (E/I) brain activity as underlying mechanism reading difficulties. This study provides the first direct test this using both EEG power spectrum measures in 120 Polish adolescents young adults (60 with dyslexia, 60 controls) glutamate (Glu) gamma-aminobutyric acid (GABA) concentrations from magnetic resonance spectroscopy (MRS) at 7T MRI scanner half sample. Our results, supported by Bayesian statistics, show no evidence E/I balance differences groups, challenging that cortical hyperexcitability underlies dyslexia. These findings suggest alternative mechanisms must be explored highlight need for further research into its role neurodevelopmental disorders.

Language: Английский

Citations

0
Heterochronous laminar maturation in the human prefrontal cortex DOI Creative Commons
Valerie J. Sydnor, Daniel Petrie, Shane D. McKeon

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

The human prefrontal cortex (PFC) exhibits markedly protracted developmental plasticity, yet whether reductions in plasticity occur synchronously across cortical layers is unclear. Animal studies have shown that intracortical myelin consolidates neural circuits to close periods of plasticity. Here, we use quantitative imaging collected from youth (ages 10-32 years) at ultra-high field (7T) investigate deep and superficial PFC exhibit different timeframes We find matures along a deep-to-superficial axis the PFC; this maturational timing expressed extent cytoarchitecturally distinct regions frontal hierarchy. By integrating mapping with electroencephalogram cognitive phenotyping, provide evidence dissociably impact timescales activity, task learning rates, processing speed. Heterochronous maturation an underrecognized mechanism through which association balances cognitively-relevant increases circuit stability efficiency extended neuroplasticity.

Language: Английский

Citations

0
The Neonatal Microbiome: Implications for Amyotrophic Lateral Sclerosis and Other Neurodegenerations DOI Creative Commons
Andrew Eisen, Matthew C. Kiernan

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 195 - 195

Published: Feb. 14, 2025

Most brain development occurs in the "first 1000 days", a critical period from conception to child's second birthday. Critical processes that occur during this time include synaptogenesis, myelination, neural pruning, and formation of functioning neuronal circuits. Perturbations first days likely contribute later-life neurodegenerative disease, including sporadic amyotrophic lateral sclerosis (ALS). Neurodevelopment is determined by many events, maturation colonization infant microbiome its metabolites, specifically neurotransmitters, immune modulators, vitamins, short-chain fatty acids. Successful gut-brain axis function depend on maternal factors (stress exposure toxins pregnancy), mode delivery, quality postnatal environment, diet after weaning breast milk, nutritional deficiencies. While neonatal highly plastic, it remains prone dysbiosis which, once established, may persist into adulthood, thereby inducing chronic inflammation abnormal excitatory/inhibitory balance, resulting excitation. Both are recognized as key pathophysiological ALS.

Language: Английский

Citations

0
Reevaluating the neural noise in dyslexia using biomarkers from electroencephalography and high-resolution magnetic resonance spectroscopy DOI Creative Commons
Agnieszka Glica,

Katarzyna Wasilewska,

Julia Jurkowska

et al.

eLife, Journal Year: 2025, Volume and Issue: 13

Published: March 3, 2025

The neural noise hypothesis of dyslexia posits an imbalance between excitatory and inhibitory (E/I) brain activity as underlying mechanism reading difficulties. This study provides the first direct test this using both electroencephalography (EEG) power spectrum measures in 120 Polish adolescents young adults (60 with dyslexia, 60 controls) glutamate (Glu) gamma-aminobutyric acid (GABA) concentrations from magnetic resonance spectroscopy (MRS) at 7T MRI scanner half sample. Our results, supported by Bayesian statistics, show no evidence E/I balance differences groups, challenging that cortical hyperexcitability underlies dyslexia. These findings suggest alternative mechanisms must be explored highlight need for further research into its role neurodevelopmental disorders.

Language: Английский

Citations

0
Developmental decorrelation of local cortical activity through adolescence supports high-dimensional encoding and working memory DOI Creative Commons
Finnegan J. Calabro,

Dylan LeCroy,

Will Foran

et al.

Developmental Cognitive Neuroscience, Journal Year: 2025, Volume and Issue: 73, P. 101541 - 101541

Published: March 4, 2025

Adolescence is a key period for the maturation of cognitive control during which cortical circuitry refined through processes such as synaptic pruning, but how these refinements modulate local functional dynamics to support cognition remains only partially characterized. Here, we used data from longitudinal, adolescent cohort (N = 134 individuals ages 10-31 years, N 202 total sessions) that completed MRI scans at ultra-high field (7 Tesla). We resting state fMRI compute surface-based regional homogeneity (ReHo)-a measure time-dependent correlations in activity between vertex and its immediate neighbors-as an index connectivity across cortex. found widespread decreases ReHo, suggesting increasing heterogeneity specialization circuits adolescence. Decreases ReHo included spatial component overlapped with sensorimotor cingulo-opercular networks, were associated developmental stabilization working memory performance. show are higher intrinsic coding dimensionality, demonstrating may confer computational benefits by facilitating increased capacity encoding information. These results suggest remodeling adolescence become increasingly specialized, higher-dimensional, more capable supporting adult-like functioning.

Language: Английский

Citations

0
Effects of neural oscillation power and phase on discrimination performance in a visual tilt illusion DOI Creative Commons
J. G. Williams, William J. Harrison, Henry A. Beale

et al.

Current Biology, Journal Year: 2024, Volume and Issue: 34(8), P. 1801 - 1809.e4

Published: April 1, 2024

Language: Английский

Citations

3
Adolescent maturation of dorsolateral prefrontal cortex glutamate:GABA and cognitive function is supported by dopamine-related neurobiology DOI
Ashley C. Parr,

Maria I. Perica,

Finnegan J. Calabro

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 9, 2024

Language: Английский

Citations

2