Change in aperiodic activity over first year of life is associated with later autism diagnosis and 18-month language development in infants with family history of autism DOI Creative Commons
Carol L. Wilkinson, Haerin Chung, Abhishek Dave

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Delays in language often co-occur among toddlers diagnosed with autism. Despite the high prevalence of delays, neurobiology underlying such challenges remains unclear. Prior research has shown reduced EEG power across multiple frequency bands 3-to-6-month-old infants an autistic sibling, followed by accelerated increases age. Here we apply new methods to decompose spectra into aperiodic (broad band neural firing) and periodic (oscillations) activity explore possible links between changes first year life later outcomes. Combining data two longitudinal studies without siblings, assessed whether elevated familial likelihood (EFL) exhibit altered both at 3 12 months age, compared those a low (LL), developmental change is associated development. At 3-months observed that EFL have significantly lower from 6.7-55Hz (p<0.05). However, was increased diagnosis autism, autism diagnosis. In addition, greater offset slope 3-to12-months were worse development measured 18 months. Findings suggest early age-dependent may serve as potential indicators family history

Language: Английский

Reevaluating the Neural Noise Hypothesis in Dyslexia: Insights from EEG and 7T MRS Biomarkers DOI Creative Commons
Agnieszka Glica,

Katarzyna Wasilewska,

Julia Jurkowska

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 12, 2024

Abstract The neural noise hypothesis of dyslexia posits an imbalance between excitatory and inhibitory (E/I) brain activity as underlying mechanism reading difficulties. This study provides the first direct test this using both indirect EEG power spectrum measures in 120 Polish adolescents young adults (60 with dyslexia, 60 controls) glutamate (Glu) gamma-aminobutyric acid (GABA) concentrations from magnetic resonance spectroscopy (MRS) at 7T MRI scanner half sample. Our results, supported by Bayesian statistics, show no evidence E/I balance differences groups, challenging that cortical hyperexcitability underlies dyslexia. These findings suggest alternative mechanisms must be explored highlight need for further research into its role neurodevelopmental disorders.

Language: Английский

Citations

1
The development of aperiodic neural activity in the human brain DOI Creative Commons
Zachariah R. Cross, Stephen Gray, Adam J. O. Dede

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

The neurophysiological mechanisms supporting brain maturation are fundamental to attention and memory capacity across the lifespan. Human regions develop at different rates, with many developing into third fourth decades of life. Here, in this preregistered study (https://osf.io/gsru7), we analyzed intracranial EEG (iEEG) recordings from widespread a large developmental cohort. Using task-based (i.e., to-be-remembered visual stimuli) task-free (resting-state) data 101 children adults (5.93 - 54.00 years, 63 males;

Language: Английский

Citations

1
Modifiable dementia risk associated with smaller white matter volume and altered 1/f aperiodic brain activity: cross-sectional insights from the LEISURE study DOI Creative Commons

Thomas Pace,

Jacob M. Levenstein, Toomas Erik Anijärv

et al.

Age and Ageing, Journal Year: 2024, Volume and Issue: 53(11)

Published: Oct. 25, 2024

The rising prevalence of dementia necessitates identifying early neurobiological markers risk. Reduced cerebral white matter volume and flattening the slope electrophysiological 1/f spectral power distribution provide brain ageing alongside cognitive decline. However, their association with modifiable risk remains to be understood.

Language: Английский

Citations

1
Prefrontal Excitation/ Inhibition Balance Supports Adolescent Enhancements in Circuit Signal to Noise Ratio DOI Creative Commons
Shane D. McKeon,

Maria I. Perica,

Finnegan J. Calabro

et al.

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 243, P. 102695 - 102695

Published: Nov. 30, 2024

Language: Английский

Citations

1
Dissociating Contributions of Theta and Alpha Oscillations from Aperiodic Neural Activity in Human Visual Working Memory DOI Open Access
Quirine van Engen,

Geeling Chau,

Aaron Smith

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Abstract While visual working memory (WM) is strongly associated with reductions in occipitoparietal 8-12 Hz alpha power, the role of 4-7 frontal midline theta power less clear, both increases and decreases widely reported. Here, we test hypothesis that this paradox can be explained by non-oscillatory, aperiodic neural activity dynamics. Because traditional time-frequency analyses electroencephalopgraphy (EEG) data conflate oscillations activity, event-related changes manifest as task-related apparent oscillations, even when none are present. Reanalyzing EEG from two WM experiments (n = 74), leveraging spectral parameterization, found systematic load, replicated classic alpha, but not theta, oscillatory effects after controlling for changes. Aperiodic decreased during retention, further flattened over cortex an increase load. After these dynamics, aperiodic-adjusted increasing In contrast, increased because reduces more, it falsely appears though “oscillatory” (e.g., bandpower) reduced. Furthermore, only a minority participants (31/74) had detectable degree oscillations. These results offer potential resolution to where studies show contrasting We identify novel dynamics human mask play cognition behavior. Significance statement Working Memory our ability hold information mind without being present external environment. Years research focused on brain discover mechanisms WM. specifically look at measured scalp their significance supporting challenge earlier findings regarding analysis approach, while replicating oscillation findings. involved WM, regions task-general manner, anterior reduced number items remembered. Thus, have identified

Language: Английский

Citations

1
Adolescent maturation of cortical excitation-inhibition balance based on individualized biophysical network modeling DOI Creative Commons
Amin Saberi, Kevin J. Wischnewski, Kyesam Jung

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 18, 2024

Summary The balance of excitation and inhibition is a key functional property cortical microcircuits which changes through the lifespan. Adolescence considered crucial period for maturation excitation-inhibition balance. This has been primarily observed in animal studies, yet human vivo evidence on adolescent at individual level limited. Here, we developed an individualized marker regional adolescents, estimated using large-scale simulations biophysical network models fitted to resting-state magnetic resonance imaging data from two independent cross-sectional (N = 752) longitudinal 149) cohorts. We found widespread relative increase association cortices paralleled by age-related excitation, or lack change, sensorimotor areas across both datasets. developmental pattern co-aligned with multiscale markers sensorimotor-association differentiation. spatial development adolescence was robust inter-individual variability structural connectomes modeling configurations. Notably, that alternative simulation-based show variable sensitivity maturational change. Taken together, our study highlights during cross sectional data, provides computational framework estimate microcircuit level.

Language: Английский

Citations

0
Prefrontal Excitation/ Inhibition Balance Supports Adolescent Enhancements in Circuit Signal to Noise Ratio DOI Creative Commons
Shane D. McKeon,

Maria I. Perica,

Finnegan J. Calabro

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 19, 2024

The development and refinement of neuronal circuitry allow for stabilized efficient neural recruitment, supporting adult-like behavioral performance. During adolescence, the maturation PFC is proposed to be a critical period (CP) executive function, driven by break in balance between glutamatergic excitation GABAergic inhibition (E/I) neurotransmission. CPs, cortical fine-tunes improve information processing reliable responses stimuli, shifting from spontaneous evoked activity, enhancing SNR, promoting synchronization. Harnessing 7T MR spectroscopy EEG longitudinal cohort (N = 164, ages 10-32 years, 283 neuroimaging sessions), we outline associations age-related changes glutamate GABA neurotransmitters measures SNR. We find developmental decreases activity increases SNR during our auditory steady state task using 40 Hz stimuli. Decreases were associated with levels DLPFC, while more balanced Glu levels. These improvements working memory This study provides evidence CP plasticity human leading that allows optimal recruitment integration multisensory input, resulting improved function.

Language: Английский

Citations

0
Reevaluating the Neural Noise Hypothesis in Dyslexia: Insights from EEG and 7T MRS Biomarkers DOI Open Access
Agnieszka Glica,

Katarzyna Wasilewska,

Julia Jurkowska

et al.

Published: Sept. 5, 2024

The neural noise hypothesis of dyslexia posits an imbalance between excitatory and inhibitory (E/I) brain activity as underlying mechanism reading difficulties. This study provides the first direct test this using both indirect EEG power spectrum measures in 120 Polish adolescents young adults (60 with dyslexia, 60 controls) glutamate (Glu) gamma-aminobutyric acid (GABA) concentrations from magnetic resonance spectroscopy (MRS) at 7T MRI scanner half sample. Our results, supported by Bayesian statistics, show no evidence E/I balance differences groups, challenging that cortical hyperexcitability underlies dyslexia. These findings suggest alternative mechanisms must be explored highlight need for further research into its role neurodevelopmental disorders.

Language: Английский

Citations

0
Reevaluating the Neural Noise Hypothesis in Dyslexia: Insights from EEG and 7T MRS Biomarkers DOI Creative Commons
Agnieszka Glica,

Katarzyna Wasilewska,

Julia Jurkowska

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: Sept. 5, 2024

The neural noise hypothesis of dyslexia posits an imbalance between excitatory and inhibitory (E/I) brain activity as underlying mechanism reading difficulties. This study provides the first direct test this using both electroencephalography (EEG) power spectrum measures in 120 Polish adolescents young adults (60 with dyslexia, 60 controls) glutamate (Glu) gamma-aminobutyric acid (GABA) concentrations from magnetic resonance spectroscopy (MRS) at 7T MRI scanner half sample. Our results, supported by Bayesian statistics, show no evidence E/I balance differences groups, challenging that cortical hyperexcitability underlies dyslexia. These findings suggest alternative mechanisms must be explored highlight need for further research into its role neurodevelopmental disorders.

Language: Английский

Citations

0
Longitudinal trajectories of aperiodic EEG activity in early to middle childhood DOI Creative Commons
Dashiell D. Sacks, Viviane Valdes, Carol L. Wilkinson

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 14, 2024

Abstract Background Emerging evidence suggests that aperiodic EEG activity may follow a nonlinear growth trajectory in childhood. However, existing studies are limited by small assessment windows and cross-sectional samples unable to fully capture these patterns. The current study aimed characterize the developmental trajectories of longitudinally from infancy middle We examined potential differences sex brain region. further investigated whether is associated with maternal anxiety symptoms, associations vary because differential development trajectories. Methods A community sample children their parents ( N =391) enrolled longitudinal emotion processing were assessed at infancy, ages 3 years, 5 7 years. Analyses included individual curve mixed effect models. Developmental slope offset across whole brain, frontal, central, temporal, posterior regions. Associations symptoms also examined. Results for both generally characterized relative increase early childhood subsequent decrease or stabilization age 7, variation Females showed relatively steeper slopes some ages, males greater certain ages. Maternal was negatively years positively Conclusions shows magnitude direction varied age, corresponding changes stage should be considered when interpreting findings related

Language: Английский

Citations

0