PLoS Genetics,
Journal Year:
2023,
Volume and Issue:
19(6), P. e1010782 - e1010782
Published: June 15, 2023
Endocrine
signaling
networks
control
diverse
biological
processes
and
life
history
traits
across
metazoans.
In
both
invertebrate
vertebrate
taxa,
steroid
hormones
regulate
immune
system
function
in
response
to
intrinsic
environmental
stimuli,
such
as
microbial
infection.
The
mechanisms
of
this
endocrine-immune
regulation
are
complex
constitute
an
ongoing
research
endeavor
facilitated
by
genetically
tractable
animal
models.
20-hydroxyecdysone
(20E)
is
the
major
hormone
arthropods,
primarily
studied
for
its
essential
role
mediating
developmental
transitions
metamorphosis;
20E
also
modulates
innate
immunity
a
variety
insect
taxa.
This
review
provides
overview
our
current
understanding
20E-mediated
responses.
prevalence
correlations
between
20E-driven
activation
summarized
range
holometabolous
insects.
Subsequent
discussion
focuses
on
studies
conducted
using
extensive
genetic
resources
available
Drosophila
that
have
begun
reveal
underlying
contexts
development
bacterial
Lastly,
I
propose
directions
future
into
will
advance
knowledge
how
interactive
endocrine
coordinate
animals'
physiological
responses
microbes.
Cells,
Journal Year:
2022,
Volume and Issue:
11(5), P. 914 - 914
Published: March 7, 2022
The
existence
of
orderly
structures,
such
as
tissues
and
organs
is
made
possible
by
cell
adhesion,
i.e.,
the
process
which
cells
attach
to
neighbouring
a
supporting
substance
in
form
extracellular
matrix.
matrix
three-dimensional
structure
composed
collagens,
elastin,
various
proteoglycans
glycoproteins.
It
storehouse
for
multiple
signalling
factors.
Cells
are
informed
their
correct
connection
via
receptors.
Tissue
disruption
often
prevents
natural
reconstitution
use
appropriate
implants
then
required.
This
review
compilation
crucial
information
on
structural
functional
features
complex
mechanisms
cell–cell
connectivity.
possibilities
regenerating
damaged
using
an
artificial
substitute
described,
detailing
host
response
implant.
An
important
issue
surface
properties
implant
modification.
Science,
Journal Year:
2024,
Volume and Issue:
383(6689)
Published: March 21, 2024
Brassinosteroids
are
steroidal
phytohormones
that
regulate
plant
development
and
physiology,
including
adaptation
to
environmental
stresses.
synthesized
in
the
cell
interior
but
bind
receptors
at
surface,
necessitating
a
yet
be
identified
export
mechanism.
Here,
we
show
member
of
ATP-binding
cassette
(ABC)
transporter
superfamily,
ABCB19,
functions
as
brassinosteroid
exporter.
We
present
its
structure
both
substrate-unbound
brassinosteroid-bound
states.
Bioactive
brassinosteroids
potent
activators
ABCB19
ATP
hydrolysis
activity,
transport
assays
showed
transports
brassinosteroids.
In
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 6, 2025
Abstract
Female
reproduction
comes
at
great
expense
to
energy
metabolism
compensated
by
extensive
organ
adaptations
including
intestinal
size.
Upon
mating,
endocrine
signals
orchestrate
a
30%
net
increase
of
absorptive
epithelium.
Mating
increases
production
the
steroid
hormone
Ecdysone
released
Drosophila
ovaries
that
stimulates
stem
cell
(ISC)
divisions.
Here,
we
uncover
transcription
factor
crooked
legs
(crol)
as
an
intraepithelial
coordinator
Ecdysone-induced
ISC
mitosis.
For
precise
investigation
non-autonomous
factors
on
behaviour,
establish
Rapport,
spatiotemporally-controlled
dual
expression
and
tracing
system
for
analysis
paracrine
genetic
manipulation
while
behaviour.
Rapport
reveals
Crol
controls
mitogenic
Wnt/Wg-ligand
from
epithelial
enterocytes
activating
Paracrine
Wg
stimulation
is
counterbalanced
Crol-repression
string/CDC25
CyclinB
autonomously
in
ISC.
Rapport-based
tumours
confirm
through
Ecdysone-Crol-Wg
axis
mitotic
whereas
autonomous
anti-proliferative
role
conserved
models
colorectal
cancer.
Finally,
mathematical
modelling
corroborates
increasing
enterocyte
numbers
Wnt/Wg-degradation
set
stable
post-mating
Together,
our
findings
provide
insights
into
complex
growth
control
mechanisms
during
mating-induced
might
help
untangling
pleiotropic
hormonal
effects
observed
gastrointestinal
tumorigenesis.
Genetics,
Journal Year:
2020,
Volume and Issue:
216(2), P. 269 - 313
Published: Oct. 1, 2020
Abstract
The
control
of
body
and
organ
growth
is
essential
for
the
development
adults
with
proper
size
proportions,
which
important
survival
reproduction.
In
animals,
adult
determined
by
rate
duration
juvenile
growth,
are
influenced
environment.
nutrient-scarce
environments
in
more
time
needed
period
can
be
extended
delaying
maturation,
whereas
rapidly
completed
nutrient-rich
conditions.
This
flexibility
requires
integration
environmental
cues
developmental
signals
that
govern
internal
checkpoints
to
ensure
maturation
does
not
begin
until
sufficient
tissue
has
occurred
reach
a
size.
Target
Rapamycin
(TOR)
pathway
primary
cell-autonomous
nutrient
sensor,
while
circulating
hormones
such
as
steroids
insulin-like
factors
main
systemic
regulators
animals.
We
discuss
recent
findings
Drosophila
melanogaster
showing
environment
growth-sensing
mechanisms,
involving
TOR
other
growth-regulatory
pathways,
converge
on
insulin
steroid
relay
centers
responsible
adjusting
development,
response
external
addition
this,
also
monitored
coordinated
whole-body
timing
through
modulation
signaling.
coordination
involves
interorgan
communication
mediated
peptide
8
status.
Together,
these
multiple
nutritional
feed
into
neuroendocrine
hubs
controlling
signaling,
serving
at
progression
toward
delayed.
review
focuses
mechanisms
conditions
modulate
size,
highlights
conserved
architecture
this
system,
made
prime
model
understanding
Genetics,
Journal Year:
2020,
Volume and Issue:
216(4), P. 837 - 878
Published: Dec. 1, 2020
Abstract
Caenorhabditis
elegans
survives
on
ephemeral
food
sources
in
the
wild,
and
species
has
a
variety
of
adaptive
responses
to
starvation.
These
features
its
life
history
make
worm
powerful
model
for
studying
developmental,
behavioral,
metabolic
starvation
responses.
Starvation
resistance
is
fundamental
it
relevant
aging
common
diseases
such
as
cancer
diabetes.
Worms
respond
acute
at
different
times
cycle
by
arresting
development
altering
gene
expression
metabolism.
They
also
anticipate
during
early
larval
development,
engaging
an
alternative
developmental
program
resulting
dauer
diapause.
By
these
postpone
growth
reproduction
until
feeding
resumes.
A
set
signaling
pathways
mediates
systemic
regulation
each
context
but
with
important
distinctions.
Several
aspects
behavior,
including
feeding,
foraging,
taxis,
egg
laying,
sleep,
associative
learning,
are
affected
conserved
signaling,
regulatory,
mechanisms
support
adaptation
Early
can
have
persistent
effects
adults
their
descendants.
With
short
generation
time,
C.
ideal
maternal
provisioning,
transgenerational
epigenetic
inheritance,
origins
adult
health
disease
humans.
This
review
provides
comprehensive
overview
throughout
cycle.
Developmental
studies
revealed
fundamental
principles
on
how
organ
size
and
function
is
achieved,
but
less
known
about
adaptation
to
new
physiological
demands.
In
fruit
flies,
juvenile
hormone
(JH)
induces
intestinal
stem
cell
(ISC)
driven
absorptive
epithelial
expansion
balancing
energy
uptake
with
increased
demands
of
pregnancy.
Here,
we
show
20-Hydroxy-Ecdysone
(20HE)-signaling
controlling
homeostasis
pathological
implications.
Upon
mating,
20HE
titer
in
ovaries
hemolymph
are
act
nearby
midgut
progenitors
inducing
Ecdysone-induced-protein-75B
(Eip75B).
Strikingly,
the
PPARγ
-homologue
Eip75B
drives
ISC
daughter
cells
towards
enterocyte
lineage
ensuring
growth.
To
our
knowledge,
this
first
time
a
systemic
shown
direct
local
fate
decisions.
Given
protective,
mechanistically
unclear
role
steroid
hormones
female
colorectal
cancer
patients,
findings
suggest
tumor-suppressive
for
steroidal
signaling
by
promoting
postmitotic
when
deteriorated.
Frontiers in Pharmacology,
Journal Year:
2021,
Volume and Issue:
12
Published: Aug. 10, 2021
The
solute
carrier
(SLC)
superfamily
represents
the
biggest
family
of
transporters
with
important
roles
in
health
and
disease.
Despite
being
attractive
druggable
targets,
majority
SLCs
remains
understudied.
One
major
hurdle
research
on
is
lack
tools,
such
as
cell-based
assays
to
investigate
their
biological
role
for
drug
discovery.
Another
challenge
disperse
anecdotal
information
assay
strategies
that
are
suitable
SLCs.
This
review
provides
a
comprehensive
overview
state-of-the-art
cellular
technologies
SLC
discusses
relevant
characteristics
enabling
choice
an
optimal
technology.
Innovative
Medicines
Initiative
consortium
RESOLUTE
intends
accelerate
by
providing
scientific
community
high-quality
reagents,
data
sets,
ultimately
unlock
Open Biology,
Journal Year:
2021,
Volume and Issue:
11(2)
Published: Feb. 1, 2021
In
both
mammals
and
insects,
steroid
hormones
play
a
major
role
in
directing
the
animal's
progression
through
developmental
stages.
To
maximize
fitness
outcomes,
hormone
production
is
regulated
by
environmental
conditions
experienced
animal.
ecdysone
mediates
transitions
between
stages
response
to
factors
such
as
nutrition.
These
signals
are
communicated
ecdysone-producing
gland
via
action
of
neuropeptide
peptide
signalling
pathways.
While
some
these
pathways
have
been
well
characterized,
there
evidence
suggest
more
than
has
previously
thought
function
control
production,
potentially
greater
range
conditions.
Here,
we
review
known
regulate
model
genetic
insect
Drosophila
melanogaster
,
what
regarding
that
trigger
Areas
for
future
research
highlighted
can
further
contribute
our
overall
understanding
complex
orchestration
environmental,
physiological
cues
together
produce
functioning
adult
organism.