Ultra-Processed Foods and Type 2 Diabetes Mellitus: What Is the Evidence So Far?
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 307 - 307
Published: Feb. 19, 2025
Ultra-processed
foods
(UPFs)
are
that
have
undergone
extensive
industrial
processing
with
the
addition
of
various
substances
in
order
to
make
them
more
tasty,
eye-catching,
and
easy
consume.
UPFs
usually
rich
sugars,
salt,
saturated
fat,
whereas
they
lack
essential
nutrients.
The
aim
this
review
is
elaborate
upon
current
evidence
associating
overconsumption
development
type
2
diabetes
mellitus
(T2DM).
We
will
discuss
data
interconnecting
T2DM
risk
further
describe
specific
ingredients
been
suggested
increase
risk.
In
addition,
we
thoroughly
explain
how
additives,
such
as
emulsifiers
or
sweeteners,
other
compounds
formed
during
manufacturing,
acrylamide
acrolein,
packaging,
bisphenol-A,
proposed
be
implicated
pathogenesis
insulin
resistance
T2DM.
Language: Английский
Comparing phthalate exposure between bottlenose dolphins (Tursiops truncatus) residing in urban and rural environments
Frontiers in Marine Science,
Journal Year:
2025,
Volume and Issue:
12
Published: May 12, 2025
Introduction
Exposure
to
phthalate
esters
has
previously
been
documented
in
bottlenose
dolphins
(
Tursiops
truncatus
)
inhabiting
an
urban
estuary
(Sarasota
Bay,
FL,
USA;
2010-2019).
Phthalates
are
chemicals
commonly
added
plastic
products
and
consumer
goods
enhance
qualities
such
as
flexibility,
fragrance,
stability.
Chemical
leaching
from
into
the
marine
environment
leaves
wildlife
vulnerable
reproductive,
developmental,
metabolic
impairment.
Environmental
exposure
shown
vary
relative
human
activity
urbanization.
Methods
To
evaluate
potential
differences
dolphin
risk,
urine
was
collected
free-ranging
residing
2010-2024;
n=71)
rural
(Barataria
LA,
2011-
2023;
n=45).
Urinary
metabolite
concentrations
were
quantified
with
high-performance
liquid
chromatography
(HPLC;
Agilent
1100;
WatersXBridge
BEH
C18,
2.5
μm,
2.1x50
mm
analytical
column)
coupled
a
triple
quadrupole
mass
spectrometer
(MS;
Applied
Biosystems
Sciex
API
4000)
electrospray
ionization
(ESI
negative)
interface.
Results
The
magnitude
of
MEHP
detection
did
not
differ
significantly
between
sampling
sites
(p=0.97);
however,
detected
more
frequently
Sarasota
Bay
(73.24%;
n=52;
95%
CI:
61.20-82.73)
than
Barataria
(33.33%;
n=15;
20.00-48.95%).
Dolphins
may
be
exposed
greater
diversity
phthalates
compared
dolphins,
indicated
by
profile.
Discussion
Notably,
impacted
Deepwater
Horizon
oil
spill,
evidence
suggesting
long-term
negative
health
outcomes.
endocrine-disrupting
effects
could
exacerbate
metabolic,
or
immune
dysfunction
especially
those
compromised
health.
higher
frequency
suggests
increased
risks;
raises
concerns
for
recovering
ecosystems.
Further
research
is
needed
assess
synergistic
impacts
chemical
mixtures,
targeted
mitigation
strategies
contaminated
environments.
Language: Английский
Individual and joint effects of exposure to phthalates and the risk of cardiovascular disease in the chronic kidney disease population: NHANES 2005–2018
Frontiers in Public Health,
Journal Year:
2025,
Volume and Issue:
13
Published: May 14, 2025
Background
There
is
a
lack
of
studies
on
the
relationship
between
urinary
phthalate
metabolites
(UPMs)
and
cardiovascular
disease
(CVD)
prevalence
in
adults
suffering
from
chronic
kidney
(CKD).
We
intended
to
examine
UPMs
CVD
people
with
CKD.
Methods
The
research
utilized
data
National
Health
Nutrition
Examination
Survey
(NHANES)
2005–2018.
employed
three
statistical
models—a
generalized
linear
regression
model,
weighted
quantile
sum
(WQS)
Bayesian
kernel
machine
(BKMR)
model.
Results
included
834
CKD
participants
finally.
In
was
higher
individuals
MiBP
(OR
1.86;
95%
CI
1.08–3.18;
P
for
trend
=
0.022),
MCNP
1.85;
1.18–2.91;
0.011),
MBP
1.68;
1.02–2.76;
0.041)
MECPP
2.22;
1.28–3.86;
0.008)
highest
tertile
compared
those
lowest
tertile.
WQS
index
significantly
positively
associated
1.44;
1.04–1.99;
p
value
0.028).
Among
ten
phthalates,
showed
weight
(weighted
0.21).
A
positive
link
mixture
exposure
also
demonstrated
by
BKMR
conditional
posterior
inclusion
probabilities
(condPIPs)
obtained
model
indicated
that
were
primary
contributors
overall
effect
observed
group,
condPIP
values
0.581
0.508,
respectively.
Conclusion
results
linked
an
elevated
risk
highlighted
need
reduce
plastic
use
among
population.
Language: Английский