Opposite outcomes of triglyceride-glucose index and associated cardiovascular mortality risk in type 2 diabetes mellitus participants by different obesity criteria

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 16, 2025

We investigated the correlation between Triglyceride-glucose (TyG) index and cardiovascular disease (CVD) mortality in type 2 diabetes mellitus (T2DM) population across different obesity classications using a cohort study. analyzed 7867 T2DM participants from National Health Nutrition Examination Survey 1999-2018, categorizing them into obese or non-obese group by body mass (BMI) waist circumference (WC). Cox regression models were used to estimate TyG CVD risk, comparing results two classifications. Over 9.1-year follow-up, 691 deaths occurred. Among (BMI-defined), hazard ration for was 1.73 fourth quartile of compared with first group. Conversely, among (WC-defined), held 1.51-fold risk The association higher observed WC-defined but not BMI-defined obesity. A totally opposite relationship appeared based on how defined BMI WC participants, suggesting reevaluation BMI's accuracy predicting risk.

Language: Английский

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Triglyceride-glucose index as a marker in cardiovascular diseases; a bibliometric study and visual analysis

Annals of Medicine and Surgery, Journal Year: 2025, Volume and Issue: 87(3), P. 1487 - 1505

Published: Feb. 26, 2025

Objective: This study aims to conduct a bibliometric analysis of the triglyceride-glucose (TyG) index in relation cardiovascular disorders. Methods: Data for were extracted from Web Science Core Collection database on 13 July 2024. We utilized VOSviewer, CiteSpace, and Biblioshiny tools analysis. Results: The revealed marked increase research outputs TyG recent years, peaking with 137 publications 2023. China emerged as leading contributor, followed by USA. Chinese Academy Medical Sciences Peking Union College among top contributing institutions. Shouling Wu Shuohua Chen authors, journal Cardiovascular Diabetology publishing most articles this topic. Keyword identified “insulin-resistance” frequently occurring term, “risk.” Cluster eleven key areas, including “percutaneous coronary intervention,” “obesity indicators,” “arterial stiffness,” “heart failure.” Conclusion: highlights expanding role metabolic research. Key clusters such percutaneous intervention, obesity indicators, arterial stiffness, heart failure, new-onset hypertension, predicting outcomes, subclinical artery disease emphasize its wide applicability across diverse clinical settings. keyword “risk” was underscoring importance risk assessment, alongside growing use prognostic applications. These findings reflect increasing recognition pivotal biomarker medicine encourage further exploration integration.

Language: Английский

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Association between socioeconomic status and the triglyceride glucose index: a cross-sectional study based on NHANES 2007–2016

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 10, 2025

The triglyceride glucose index (TyG index) is a crucial marker for assessing the risk of chronic diseases, while socioeconomic status (SES), measured by poverty income ratio (PIR) and education level, reflects an individual's social standing. Past studies have linked SES to diabetes cardiovascular but research on its association with TyG limited. This study aimed explore between assess mediating role BMI. cross-sectional utilized data from National Health Nutrition Examination Survey 2007–2016 cycles relationship in adult USA. Multivariate logistic regression, stratified interaction analyses were conducted index. Additionally, parallel mediator analysis estimated mediated effect BMI Among 11,358 individuals studied, averaging 49 years age 48.3% males, fully adjusted models revealed negative associations PIR level index, showed positive correlation. Stratified indicated consistent findings across subgroups. Mediation that 14.4% 8.57% effects PIR/Education respectively. was negatively associated partially mediate These deepen comprehension

Language: Английский

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Association between high triglyceride-glucose index and MACCE in hypertriglyceridemia patients undergoing percutaneous coronary intervention

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 14, 2025

Background With a focus on metabolism-related cardiovascular diseases, the triglyceride-glucose (TyG) index has been used as surrogate marker of insulin resistance in prognosis coronary heart disease. However, prognostic role TyG patients with elevated triglycerides, still requires further research. This study aimed to investigate association between and Major Adverse Cardiac Cerebrovascular Events (MACCE) hypertriglyceridemia undergoing drug-eluting stent percutaneous intervention (DES-PCI). Methods Out 2250 patients, 813 who underwent DES-PCI were retrospectively analyzed. MACCE was regarded primary endpoint. Kaplan–Meier (KM) curves evaluate different endpoints. Restricted cubic spline (RCS) analysis examine relation MACCE. Subgroup conducted interaction subgroup indicators. Results Cox regression identified an independent predictor (hazard ratio [HR] 1.53, 95% confidence interval [CI] 1.15–2.04, P = 0.004). Receiver operating characteristic (ROC) determined 9.19 cutoff value index. The curve indicated that > had higher risks (HR 2.23, CI 1.35–3.67, 0.002), MACE 2.38, 1.39–4.09, unplanned repeat revascularization 2.05, 1.02–4.09, 0.043) all-cause death 3.31, 95%CI 1.15–9.47, 0.026) than those low RCS revealed linear risk (P for nonlinearity 0.879, overall trend 0.044). Conclusions demonstrated high is associated increased MACCE, suggesting may serve valuable DES-PCI.

Language: Английский

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Insulin Resistance and Impaired Insulin Secretion Predict Incident Diabetes: A Statistical Matching Application to the Two Korean Nationwide, Population-Representative Cohorts

Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

To evaluate whether insulin resistance and impaired secretion are useful predictors of incident diabetes in Koreans using nationwide population-representative data to enhance privacy.

Language: Английский

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Second‐trimester triglyceride‐glucose index to predict adverse outcomes in women with gestational diabetes mellitus: A retrospective multicenter cohort study

Journal of Diabetes Investigation, Journal Year: 2024, Volume and Issue: 15(10), P. 1489 - 1499

Published: July 15, 2024

ABSTRACT Aims/Introduction Women with gestational diabetes mellitus are at high risk for adverse maternal and neonatal outcomes. The study aimed to evaluate the performance of triglyceride‐glucose index in predicting developing outcomes women mellitus. Materials Methods This retrospective multicenter cohort included 8,808 pregnant two grade‐A tertiary hospitals China during 2018–2022. was defined as ln [triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. Significant were chosen by generalized linear models main Multivariable logistic regression evaluated their association index. Areas under receiver operating characteristic curves predicted pregnancy prediction efficiency validated sensitivity analysis dataset validation cohort. Results associated preeclampsia, severe preterm birth, placenta accreta spectrum, macrosomia before after adjusting confounding factors ( P < 0.05). predictive relatively moderate. Incorporating into baseline clinical model improved area diagnosis preeclampsia (0.749 [0.714–0.784] vs 0.766 [0.734–0.798], = 0.033) (0.664 [0.644–0.685] 0.676 [0.656–0.697], 0.002). These exhibited good calibration robustness. Conclusions is positively useful early prevention

Language: Английский

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Triglyceride-glucose index and glycemic dynamics in pancreatic ductal adenocarcinoma: implications for disease progression and prognosis

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 30, 2024

Abstract Background To elucidate the relationship between triglyceride-glycemic index (TyG) and clinical characteristics of pancreatic ductal adenocarcinoma (PDAC). Methods A total 1,594 individuals diagnosed with periampullary neoplasms were categorized into four groups: PDAC-early ( n = 403), locally advanced PDAC (LAPC, 315), PDAC-late distant metastasis 371), other tumor types 505). TyG-high was defined as a TyG greater than 8.81 in males 8.73 females. Results The prevalence status highest (68.48%), followed by LAPC (53.33%), lowest (44.47%). significantly predicted worse prognosis P 0.0166), particularly 0.0420). Despite similar blood glucose levels across groups 0.897), patients showed higher rates glycemic disturbances (56.33% vs. 32.28%) (68.48% 47.13%) compared to those tumors. Progressive increases observed from benign pre-malignant lesions PDAC-early. at head exhibited (58.12% 33.33%, < 0.0001), larger duct diameters (0.4056 cm 0.3398 cm, 0.0043), poorer cancers, although rate body mass similar. Conclusion exhibits complex association stages, profoundly shaping profiles. At initial stages PDAC, notable elevation is observed. However, while diminishes, abnormal persist.

Language: Английский

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Isotretinoin increases non-insulin-based surrogate markers of insulin resistance in acne vulgaris patients

Cutaneous and Ocular Toxicology, Journal Year: 2024, Volume and Issue: 43(4), P. 410 - 415

Published: Oct. 1, 2024

Lipid indices, particularly the triglyceride-glucose index (TyG index) and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio, are simple, reliable, non-insulin-based surrogate markers of insulin resistance that have recently gained prominence. The aim this study was to evaluate effect isotretinoin treatment on resistance, in particular TyG index, patients with acne vulgaris (AV).

Language: Английский

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