Prevalence of Diabetes, Hypertension, and Associated of Cardiovascular Diseases: A Comparative Pre- and Post-Covid Study DOI Creative Commons
Manuela Chiavarini, Jacopo Dolcini,

Giorgio Firmani

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(12), P. 329 - 329

Published: Dec. 13, 2024

Background: Diabetes and hypertension are major global health challenges aggravated by COVID-19’s impact on healthcare lifestyle factors. This study aims to compare the prevalence associated socio-demographic factors of these conditions before after pandemic (2019 vs. 2022). Materials Methods: We used data from Italy’s “Aspects Daily Life” survey; 74,294 adults were included. Results: Results show a rise in diabetes 7.76% 2019 8.49% 2022 (p < 0.05), while did not this. Logistic regression analysis for years revealed statistically significant association between year increased odds (OR = 1.08, p 0.008). BMI’s role as risk factor intensified, with higher ratios (ORs) both overweight obese individuals 2022. For example, obesity-related ORs 2.45 (95%CI 1.73–3.47) 3.02 2.09–4.35) 2022, 2.86 2.28–3.58) 3.64 2.87–4.61). Lower education levels also showed greater 2022; subjects only middle or high school diplomas had significantly than education; there was non-significant trend 2019. However, lower remained stable years. Conclusions: These findings suggest that may have hypertension, particularly BMI educational level, compared literature burden chronic diseases during COVID-19.

Language: Английский

Role of Oxidative Balance Score in Staging and Mortality Risk of Cardiovascular-Kidney-Metabolic Syndrome: Insights from Traditional and Machine Learning Approaches DOI Creative Commons
Yang Chen, Shuang Wu, Hongyu Liu

et al.

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103588 - 103588

Published: March 7, 2025

To evaluate the roles of oxidative balance score (OBS) in staging and mortality risk cardiovascular-kidney-metabolic syndrome (CKM). Data this study were from National Health Nutrition Examination Survey 1999-2018. We performed cross-sectional analyses using multinomial logistic regression to investigate relationship between OBS CKM staging. Cox proportional hazards models used assess impact on outcomes patients. Additionally, mediation explore whether mediated relationships specific predictors (Life's Simple 7 [LS7], systemic immune-inflammation index [SII], frailty score) outcomes. Then, machine learning developed classify stages 3/4 predict all-cause mortality, with SHapley Additive exPlanations values interpret contribution components. 21,609 participants included (20,319 CKM, median [IQR] age: 52.0 [38.0-65.0] years, 54.3% male, follow-up: 9.4 [5.3-14.1] years). Lower quartiles associated advanced Moreover, lower related increased risk, compared Q4 (all-cause mortality: Q1: HR 1.31, 95% CI 1.18-1.46, Q2: 1.27, 1.14-1.42, Q3: 1.18, 1.06-1.32; cardiovascular 1.44, 1.16-1.79, 1.39, 1.11-1.74, 1.26, 1.01-1.57; non-cardiovascular 1.12-1.44, 1.23, 1.08-1.40, 1.16, 1.02-1.31), optimal stratification threshold for was 22. (ranging 4.25%-32.85 %) effects SII, LS7, scores light gradient boosting achieved highest performance predicting (area under curve: 0.905) 0.875). Cotinine while magnesium, vitamin B6, physical activity protective. This highlights as a tool emphasizing stress's role management.

Language: Английский

Citations

1
Low LDL-cholesterol drives the risk of bleeding in patients treated with aspirin: A 15-year study in a real-world large population DOI Creative Commons
Valentina Trimarco, Raffaele Izzo, Daniela Pacella

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107688 - 107688

Published: March 1, 2025

We aimed to investigate the link between LDL cholesterol (LDL-C) levels and hemorrhage risk over an extended period, both in subjects taking aspirin individuals not receiving any antiplatelet agent. calculated predicted adjusted relative hazard of bleeding by LDL-C concentration for whole cohort aspirin-treated subgroup. The study included 39,784 with a mean follow-up 14.9 years, totaling 500,000 patient-years. Across cohort, 3,380 events were reported, higher incidence patients <70mg/dL compared those ≥70mg/dL (9.9% vs 8.4%). In patients, multivariable analysis revealed that hemorrhagic significantly associated aging, male sex, body mass index, hypertension, <70mg/dL. These had lower event-free survival probability if their was ≥70mg/dL. Low values significant factor (HR >1) while protective <1). A stepwise increase 10mg/dL from <30 ≥200mg/dL decreasing trend entire This is first report specifically addressing relationship population low-intensity antithrombotic therapy. Our data demonstrate aspirin, below 70mg/dL bleeding, major implications long-term cardiovascular management.

Language: Английский

Citations

0
Impact of COVID-19 pandemic on rates of congenital heart disease procedures among children: prospective cohort analyses of 26 270 procedures in 17 860 children using CVD-COVID-UK consortium record linkage data DOI Creative Commons
Arun S Karthikeyan, Rachel Denholm, Sonya V. Babu‐Narayan

et al.

Open Heart, Journal Year: 2025, Volume and Issue: 12(1), P. e003054 - e003054

Published: Jan. 1, 2025

Background The COVID-19 pandemic necessitated major reallocation of healthcare services. Our aim was to assess the impact on paediatric congenital heart disease (CHD) procedures during different periods compared with prepandemic period, inform appropriate responses future health services disruptions. Methods and results We analysed 26 270 from 17 860 children between 1 January 2018 31 March 2022 in England, linking them primary/secondary care data. study period included phases, latter including three restriction corresponding relaxation periods. procedure characteristics outcomes each period. There a reduction all across periods, largest reductions first, most severe (23 2020 23 June 2020), following second restrictions (3 December 4 2021) coinciding winter pressures. During first restrictions, median per week dropped by 51 (80 vs 131 week, p=4.98×10 −08 ). Elective drove these reductions, falling 96 44 (p=1.89×10 −06 ), while urgent (28 27 p=0.649) life-saving/emergency (7 6 p=0.198) remained unchanged. Cardiac surgery rates increased, catheter-based reduced pandemic. Procedures for under year were prioritised, especially four No evidence found differences postprocedure complications (age-adjusted OR 1.1 (95% CI 0.9, 1.4)) or mortality (age case mix adjusted 0.9 0.6, 1.3)). Conclusions Prioritisation urgent, emergency life-saving pandemic, particularly infants, did not CHD mortality. This information is valuable disruptions, though longer-term follow-up effects delaying elective needed.

Language: Английский

Citations

0
Cardiovascular–Kidney–Metabolic Syndrome: A New Paradigm in Clinical Medicine or Going Back to Basics? DOI Open Access

Victoria Mutruc,

Cristina Bologa, Victoriţa Şorodoc

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2833 - 2833

Published: April 19, 2025

Cardiovascular, renal, and metabolic diseases are pathophysiologically interdependent, posing a significant global health challenge being associated with substantial increase in morbidity mortality. In 2023, the American Heart Association (AHA) defined this complex network of interconnected conditions as cardiovascular–kidney–metabolic (CKM) syndrome. This syndrome is based on common pathophysiological mechanisms, including chronic inflammation, oxidative stress, hyperglycemia insulin resistance, activation renin–angiotensin–aldosterone system (RAAS), neurohormonal dysfunction, which trigger vicious cycle where impairment one organ contributes to progressive deterioration others. An integrated approach these conditions, rather than treating them separate entities, supports holistic management strategy that helps reduce burden public improve patients’ quality life. Existing focuses lifestyle modification, glycemic lipid control, use nephroprotective cardioprotective therapies. narrative review aims synthesize contextualize existing information interactions between systems diagnostic approaches, well provide an overview available therapeutic options.

Language: Английский

Citations

0
Prevalence of Diabetes, Hypertension, and Associated of Cardiovascular Diseases: A Comparative Pre- and Post-Covid Study DOI Creative Commons
Manuela Chiavarini, Jacopo Dolcini,

Giorgio Firmani

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(12), P. 329 - 329

Published: Dec. 13, 2024

Background: Diabetes and hypertension are major global health challenges aggravated by COVID-19’s impact on healthcare lifestyle factors. This study aims to compare the prevalence associated socio-demographic factors of these conditions before after pandemic (2019 vs. 2022). Materials Methods: We used data from Italy’s “Aspects Daily Life” survey; 74,294 adults were included. Results: Results show a rise in diabetes 7.76% 2019 8.49% 2022 (p < 0.05), while did not this. Logistic regression analysis for years revealed statistically significant association between year increased odds (OR = 1.08, p 0.008). BMI’s role as risk factor intensified, with higher ratios (ORs) both overweight obese individuals 2022. For example, obesity-related ORs 2.45 (95%CI 1.73–3.47) 3.02 2.09–4.35) 2022, 2.86 2.28–3.58) 3.64 2.87–4.61). Lower education levels also showed greater 2022; subjects only middle or high school diplomas had significantly than education; there was non-significant trend 2019. However, lower remained stable years. Conclusions: These findings suggest that may have hypertension, particularly BMI educational level, compared literature burden chronic diseases during COVID-19.

Language: Английский

Citations

1