Global, regional and country‐specific burden of chronic kidney disease due to type 1 diabetes mellitus: A systematic analysis of the 2021 global disease burden study DOI Creative Commons

Jianran Sun,

Wan Hu, Shandong Ye

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Chronic kidney disease (CKD) affects individual welfare, healthcare systems and societal progress. Of the multifaceted etiological factors, type 1 diabetes mellitus (T1DM) is a prominent contributor to CKD. We analysed global incidence, prevalence, deaths disability-adjusted life-years (DALYs) with age-standardised rates of CKD due T1DM (CKD-T1DM) in 2021, stratified by subtype. calculated temporal trends infirmity burden from 1990 2019 using linear regression model. The age-period-cohort (APC) Bayesian APC models predicted prospective over next 25 years. Sensitivity analysis was conducted Autoregressive Integrated Moving Average Exponential Smoothing models. Globally, there were 95 140 incidences, 6 295 711 prevalence cases, 94 020 3 875 628 DALYs CKD-T1DM. Males young-to-middle-aged individuals more likely be affected middle-socio-demographic index regions at higher risk. A considerable variation observed across Global Burden Disease super countries. number patients CKD-T1DM surged globally 2021. projections indicated continuous increase until 2046, driven ageing populations unmet therapeutic needs low-resource settings. poses growing public health threat, necessitating region-specific strategies that address inequities, promote early screening prioritise nephroprotective therapies among populations.

Language: Английский

Global, regional and country‐specific burden of chronic kidney disease due to type 1 diabetes mellitus: A systematic analysis of the 2021 global disease burden study DOI Creative Commons

Jianran Sun,

Wan Hu, Shandong Ye

et al.

Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Chronic kidney disease (CKD) affects individual welfare, healthcare systems and societal progress. Of the multifaceted etiological factors, type 1 diabetes mellitus (T1DM) is a prominent contributor to CKD. We analysed global incidence, prevalence, deaths disability-adjusted life-years (DALYs) with age-standardised rates of CKD due T1DM (CKD-T1DM) in 2021, stratified by subtype. calculated temporal trends infirmity burden from 1990 2019 using linear regression model. The age-period-cohort (APC) Bayesian APC models predicted prospective over next 25 years. Sensitivity analysis was conducted Autoregressive Integrated Moving Average Exponential Smoothing models. Globally, there were 95 140 incidences, 6 295 711 prevalence cases, 94 020 3 875 628 DALYs CKD-T1DM. Males young-to-middle-aged individuals more likely be affected middle-socio-demographic index regions at higher risk. A considerable variation observed across Global Burden Disease super countries. number patients CKD-T1DM surged globally 2021. projections indicated continuous increase until 2046, driven ageing populations unmet therapeutic needs low-resource settings. poses growing public health threat, necessitating region-specific strategies that address inequities, promote early screening prioritise nephroprotective therapies among populations.

Language: Английский

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